Articles | Volume 67, issue 1
https://doi.org/10.5194/aab-67-51-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-67-51-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original study
| 
07 Feb 2024
Original study |
| 07 Feb 2024
| 07 Feb 2024
Polymorphisms of the BMPR1B, BMP15 and GDF9 fecundity genes in four Chinese sheep breeds
Jinxin Wang
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Yufang Liu
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Siwu Guo
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Ran Di
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Xiangyu Wang
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Xiaoyun He
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Mingxing Chu
CORRESPONDING AUTHOR
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
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Huili Liang, Xingyu Du, Yujing Xie, Mingxing Chu, and Guiling Cao
Arch. Anim. Breed., 68, 435–443, https://doi.org/10.5194/aab-68-435-2025, https://doi.org/10.5194/aab-68-435-2025, 2025
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In this study, we found that Lin28a protein is expressed in the oocytes and granulosa cells of follicles at different development stages and is also expressed in the corpus luteum and corpus albicans. A mutation in intron 2 of Lin28a was found but without significant difference in terms of kidding number among the three genotypes of Jining Grey goats, an unique local breed with high prolificacy in China. A mutation in exon 4 of the Lin28b gene had an association with the litter size of Jining Grey goats.
Zizhen Ren, Xiaoyun He, Xiangyu Wang, and Mingxing Chu
Arch. Anim. Breed., 67, 153–161, https://doi.org/10.5194/aab-67-153-2024, https://doi.org/10.5194/aab-67-153-2024, 2024
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The g.405442728A>G locus of HRG exhibited moderate polymorphism (0.25<PIC<0.5) in these breeds, indicating this locus has great selection potential. It is accurate to say HRG can be used as a molecular marker to increase litter size in Small-tailed Han sheep (STH). The g.405442728A>G locus of HRG and the g.421655951C>T locus of FETUB had a significant effect on litter size in STH (P<0.05). We can use HRG and FETUB as candidate genes for the selection of litter size in sheep breeding.
Wei Wang, Yongjuan Wang, Yufang Liu, Guiling Cao, Ran Di, Jinyu Wang, and Mingxing Chu
Arch. Anim. Breed., 66, 411–419, https://doi.org/10.5194/aab-66-411-2023, https://doi.org/10.5194/aab-66-411-2023, 2023
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In this study, GLUD1 single nucleotide polymorphisms (SNPs) were analyzed in early-puberty goats and delayed-puberty goat breeds by sequencing and restriction fragment length polymorphism (RFLP). The present study aimed to find genetic markers related to sexual precocity and high fertility in goats and to provide a scientific basis for marker-assisted early selection of reproductive performance.
Si Chen, Lin Tao, Xiaoyun He, Ran Di, Xiangyu Wang, and Mingxing Chu
Arch. Anim. Breed., 64, 475–486, https://doi.org/10.5194/aab-64-475-2021, https://doi.org/10.5194/aab-64-475-2021, 2021
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Qi Han, Xiaoyun He, Ran Di, and Mingxing Chu
Arch. Anim. Breed., 64, 457–466, https://doi.org/10.5194/aab-64-457-2021, https://doi.org/10.5194/aab-64-457-2021, 2021
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Our results suggest that estrous cycles may be associated with clock gene expression in the Small-tailed Han sheep (STH sheep). This is the first study to systematically analyze the expression patterns of clock genes of different estrous cycles in ewes, which could form a basis for further studies to develop the relationship between clock genes and the estrous cycle.
Yu-Liang Wen, Xiao-Fei Guo, Lin Ma, Xiao-Sheng Zhang, Jin-Long Zhang, Sheng-Guo Zhao, and Ming-Xing Chu
Arch. Anim. Breed., 64, 211–221, https://doi.org/10.5194/aab-64-211-2021, https://doi.org/10.5194/aab-64-211-2021, 2021
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The expression and polymorphism of the BMPR1B gene associated with litter size in small-tail Han (STH) sheep were determined. We found that BMPR1B was mainly expressed in reproduction-related tissues and was more highly expressed in the hypothalamus of polytocous than in monotocous ewes in the follicular and luteal phases. A new molecular marker was found and was negatively correlated with litter size in STH sheep. These results can provide a reference for selective sheep breeding.
Ying-Jie Zhong, Yang Yang, Xiang-Yu Wang, Ran Di, Ming-Xing Chu, and Qiu-Yue Liu
Arch. Anim. Breed., 64, 131–138, https://doi.org/10.5194/aab-64-131-2021, https://doi.org/10.5194/aab-64-131-2021, 2021
Qing Xia, Xiangyu Wang, Zhangyuan Pan, Rensen Zhang, Caihong Wei, Mingxing Chu, and Ran Di
Arch. Anim. Breed., 64, 7–16, https://doi.org/10.5194/aab-64-7-2021, https://doi.org/10.5194/aab-64-7-2021, 2021
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The objective was to assess the genetic diversity and phylogenetic relationship of nine sheep populations. Overall, these sheep populations in the study exhibited a rich genetic diversity. The nine sheep populations can be divided into two groups. SUF and DST were clustered in one group, and GMM–BAS–BAM, HUS–STH and DOS–DOP were divided into three clusters. This clustering result is consistent with sheep breeding history. TreeMix analysis also hinted at the possible gene flow from GMM to SUF.
Qing Xia, Ran Di, Xiao-Yun He, Cai-Hong Wei, and Ming-Xing Chu
Arch. Anim. Breed., 63, 451–460, https://doi.org/10.5194/aab-63-451-2020, https://doi.org/10.5194/aab-63-451-2020, 2020
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The expression patterns of the HPG axis-related genes in rams were analyzed using qPCR. It showed that DIO2 and KISS1 were mainly expressed in pituitary and hypothalamus in both breeds, respectively. EYA3 and GPR54 were widely expressed in both breeds, with significant differences in testis and vas deferens. We speculated that the four genes may regulate the estrous mode in different regions in rams. This is the first study to analyze the expression patterns of HPG axis-related genes in rams.
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Functional genetics
Ovine ENSOARG00020011332 rs427117280-GG provides an increase in weaning weight and average daily gain until weaning weight in a multi-breed sheep population
FASN thioesterase domain mutation and fatty acid profile in Holstein Friesian intramuscular fat
Coat-colour-related genotypes, phenotyping and biometric assessment of three ecotypes of pigs in Cameroon
Identification of a novel InDel locus within the ACSL5 gene and its association with body measurement traits in goats
Correlation and regression analysis of the KRT27 and ELOVL4 genes in cashmere fineness and other production performances in Liaoning cashmere goats
Genome-wide association study of the antibody response to Corynebacterium pseudotuberculosis in sheep
The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing AP1S2
Exploring the association between SLC11A1 and CARD15 gene polymorphisms and tuberculosis susceptibility in Holstein cattle
Genetic analysis of platelet-derived growth factor receptor-like gene (PDGFRL) polymorphism and melanin traits in Lanping black-boned sheep (Ovis aries)
Investigating InDels in YAP and TAZ genes and their impact on growth characteristics in goats
The genetic diversity and structure of the Haflinger horse population in the Czech Republic
Evaluation of genetic diversity within different rabbit (Oryctolagus cuniculus) genotypes utilizing start codon targeted (SCoT) and inter-simple sequence repeat (ISSR) molecular markers
Analysis of genetic variants for different horn phenotypes and their inheritance in Icelandic sheep
Molecular characterization, function, tissue differential expression, and single-nucleotide polymorphism of buffalo TP53 gene
Myostatin mutation (g+6723G > A) introgression: comparative analysis of growth, slaughter, and carcass traits in Texel, Pırlak, and their crosses (F1 and BC1)
Polymorphism and expression of GLUD1 in relation to reproductive performance in Jining Grey goats
Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats
CircGUCY2C regulates cofilin 1 by sponging miR-425-3p to promote the proliferation of porcine skeletal muscle satellite cells
Novel MHC BLB2 gene polymorphism and its association with IgY concentration and Newcastle disease antibody titer in IPB-D2 chickens
Bilal Akyüz, Fadime Daldaban, Mustafa Özdemir, Ferda Karakuş, Davut Bayram, Serdar Yağcı, Ali Atik, Şeyma Kökkaya, Korhan Arslan, Emre Şirin, and Mehmet Ulaş Çınar
Arch. Anim. Breed., 68, 357–363, https://doi.org/10.5194/aab-68-357-2025, https://doi.org/10.5194/aab-68-357-2025, 2025
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The pre-weaning and weaning traits of sheep breeds native to Türkiye were studied. The rs427117280 intronic mutation in ENSOARG00020011332 was associated with the weaning weight and average daily gain until weaning in lambs. The weaning weight and average daily gain were higher for the GG genotype than for the TG and TT genotypes.
David Cancino-Baier, Erwin Muñoz-Acuña, John Quiñones, Rommy Diaz, Jorge F. Beltrán, Jorge Farías, Karla Inostroza, Rodrigo Huaiquipan, José Bento Sterman Ferraz, and Néstor Sepúlveda
Arch. Anim. Breed., 68, 271–278, https://doi.org/10.5194/aab-68-271-2025, https://doi.org/10.5194/aab-68-271-2025, 2025
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A mutation in the thioesterase domains of the fatty acid synthase enzyme reduces the percentage of myristic acid. In silico simulations were performed to assess the mutation's impact on the catalytic site's affinity for ligands and its effect on intramuscular fatty acid profiles. Tertiary structures were generated, revealing increased affinity between the mutated enzyme and myristoyl. However, the structural changes have a more significant impact on the fatty acid profile than the altered affinity.
Aveniol Idelo Nono Ekane, Ferdinand Ngoula, and Blaise Arnaud Hako Touko
Arch. Anim. Breed., 68, 239–251, https://doi.org/10.5194/aab-68-239-2025, https://doi.org/10.5194/aab-68-239-2025, 2025
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Cameroon local pigs are out-bred and neglected ecotypes, with a consistent variation in coat colours and colour patterns. The phenotypic diversity is an asset for selective breeding and genetic improvement. But it is challenging for accurate information sharing for breed utilisation, improvement and conservation perspectives. This study aimed to describe the genetic resources of pigs and to develop a standard protocol for phenotypic information sharing with the global scientific audience.
Ao Wang, Xianfeng Wu, Qian Xu, Benzhi Wang, Tianfang Xiao, Yuan Liu, and Wenyang Li
Arch. Anim. Breed., 68, 171–181, https://doi.org/10.5194/aab-68-171-2025, https://doi.org/10.5194/aab-68-171-2025, 2025
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This study investigated the spatiotemporal expression pattern of ACSL5 (acyl-CoA synthetase 5) in goats and the association between its polymorphism and body measurement traits. We found that the ACSL5 gene was expressed ubiquitously in the nine tested tissues of Fuqing goats. The del41712 locus of the ACSL5 gene has a significant impact on multiple body measurement traits of goats, providing a basis for the application of marker-assisted selection in goat breeding.
Hua Ma, Weihang Hong, Lingjun Nie, Shuaitong Li, Qingyu Yuan, Ran Duan, Qiying Zhan, Lingchao Kong, and Zeying Wang
Arch. Anim. Breed., 68, 135–149, https://doi.org/10.5194/aab-68-135-2025, https://doi.org/10.5194/aab-68-135-2025, 2025
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This study investigated single-nucleotide polymorphism (SNP) in the keratin 27 (KRT27, 1919G/A) and elongation of very-long-chain fatty acids 4 (ELOVL4, 28666C/T) genes, which are associated with production traits in Liaoning cashmere goats. Multivariate analysis was also conducted. The GGCC genotype combination was associated with finer cashmere quality. The GGTT haplotype exhibited a multigenic effect. The TT genotype demonstrated pleiotropy.
Jitka Kyselová, Ladislav Tichý, Jiřina Marková, Artur Gurgul, Zuzana Sztankóová, Karel Vališ, Soňa Šlosárková, Kateřina Kavanová, Monika Beinhauerová, and Tomasz Szmatola
Arch. Anim. Breed., 68, 109–124, https://doi.org/10.5194/aab-68-109-2025, https://doi.org/10.5194/aab-68-109-2025, 2025
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This study explored how genetics might influence the ability of sheep to fight a severe infection known as caseous lymphadenitis (CLA). By examining the genome of 321 Suffolk sheep, we identified specific genetic markers indicating biological processes and pathways that might be associated with the resistance of some sheep to this disease. This discovery is a step towards breeding sheep that are naturally more capable of fighting off CLA, potentially leading to healthier flocks.
Baoyu Zhang, Runlai Liu, Tao Ma, Xinyu Li, Yuxin Zhao, Huixian Su, Jianping Li, Yumei Li, Huaizhi Jiang, and Qiaoling Zhang
Arch. Anim. Breed., 68, 125–134, https://doi.org/10.5194/aab-68-125-2025, https://doi.org/10.5194/aab-68-125-2025, 2025
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Coat color is an important economic trait of Cashmere goats. miRNA-211 is differentially expressed in the skin of Cashmere goats with different coat colors, but the mechanism is unclear. After the targeting relationship between miRNA-211 and AP1S2 was clarified in vitro and in vivo, antagomiRNA-211 was injected into BALB/c, and the expression of miRNA-211 and AP1S2 and melanin content was analyzed. It was demonstrated that miRNA-211 impacts melanogenesis by downregulating AP1S2.
Safa Bejaoui, Nour Elhouda Fehri, Mohamed Amine Ferchichi, and Bayrem Jemmali
Arch. Anim. Breed., 67, 515–521, https://doi.org/10.5194/aab-67-515-2024, https://doi.org/10.5194/aab-67-515-2024, 2024
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Genetic variation in the SLC11A1 (C>G) and CARD15 (A/G) genes may contribute to the onset and development of bovine tuberculosis (bTB), supporting the hypothesis that polymorphisms in these genes are associated with the risk of bTB in Holstein cattle. bTB is a complicated disease that is probably influenced by polymorphisms in many genes, particularly those related to the immune system and host–pathogen interactions.
Dan Yue, Chaochao Peng, Sameeullah Memon, Azeem Iqbal, Heli Xiong, Xiaoming He, Ying Lu, and Weidong Deng
Arch. Anim. Breed., 67, 383–392, https://doi.org/10.5194/aab-67-383-2024, https://doi.org/10.5194/aab-67-383-2024, 2024
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We focus on the Lanping black-boned sheep (LPBB) because it is the only mammal that resembles the Chinese silky fowl in the world. LPBB is characterized by black pigmentation in its plasma colorimetry and had its internal organs compared to the reddish color in Lanping normal sheep. Although the literature is abundant in genetic case studies, the processes of pigmentation remain obscure. We thus investigate the association between the PDGFRL gene polymorphism of LPBB and melanin deposition.
Wanxia Zhao, Ziteng Wang, Yichen Lei, Xiaoqin Tang, Xiaohua Yi, Junyi Jiang, Jiapeng Li, Shuhui Wang, and Xiuzhu Sun
Arch. Anim. Breed., 67, 343–351, https://doi.org/10.5194/aab-67-343-2024, https://doi.org/10.5194/aab-67-343-2024, 2024
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In this study, InDels loci of YAP and TAZ genes in two goat breeds were screened and identified, and the association between InDels loci of YAP and TAZ genes and growth traits was analyzed. The results showed that eight InDels loci were identified from goat YAP and TAZ genes. These InDels loci significantly affected growth traits such as chest width, body height, and body weight of goats. These findings can provide new molecular markers for goat molecular breeding.
Michaela Kulišťáková, Iva Jiskrová, Irena Vrtková, Petra Bartoňová, and Tomáš Urban
Arch. Anim. Breed., 67, 323–333, https://doi.org/10.5194/aab-67-323-2024, https://doi.org/10.5194/aab-67-323-2024, 2024
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The aim of this study is to assess the genetic diversity and structure of the Haflinger horse population in the Czech Republic based on 16 microsatellite loci. The results indicated a high level of diversity and the presence of greater admixture, and the identification of distinct genetic clusters suggested a significant gene flow. These findings imply that the population exhibits sufficient genetic variability and diversity.
Nouran Elsayed, Abd Elrahman E. Mandour, Mamdouh K. A. Amin, Fayiz M. Reda, Heba S. A. Taha, Alessandro Di Cerbo, Mahmoud M. Azzam, and Mahmoud Alagawany
Arch. Anim. Breed., 67, 285–295, https://doi.org/10.5194/aab-67-285-2024, https://doi.org/10.5194/aab-67-285-2024, 2024
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It was suggested that the start codon targeted (SCoT) markers may be more effective than inter-simple sequence repeat (ISSR) for differentiating and identifying the genetic variations within investigated breeds. Also, the usage of molecular markers of SCoT and ISSR may be more proper for calculating genetic diversity and common ancestry among tested rabbit breeds.
Rebecca Simon, Karólína Elísabetardóttir, and Gesine Lühken
Arch. Anim. Breed., 67, 237–246, https://doi.org/10.5194/aab-67-237-2024, https://doi.org/10.5194/aab-67-237-2024, 2024
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Genetics of horn traits in sheep are still under investigation. Icelandic sheep were chosen to further characterize this complex trait using known variants as it is highly variable for horn characteristics. Only the published variant for multi-hornedness was in perfect segregation. The absence of horns was analyzed in multi-horned sheep. Only tendencies of association were found for hornlessness and for different horn shapes and sizes, confirming previous results in other breeds.
Lige Huang, Dan Sheng, Xinyang Fan, Ruixia Gao, and Yongwang Miao
Arch. Anim. Breed., 67, 217–230, https://doi.org/10.5194/aab-67-217-2024, https://doi.org/10.5194/aab-67-217-2024, 2024
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The aim of this study was to investigate the role of TP53 in buffalo lactation. The data showed that buffalo TP53 inhibited the expression of genes related to milk protein and milk fat in buffalo mammary epithelial cells by inhibiting the PI3K–AKT–mTOR pathway. These results suggest that TP53 negatively regulates the synthesis of milk protein and milk fat in buffalo through the PI3K–AKT–mTOR pathway. This study provides new insights into the functional role of TP53 in buffalo lactation.
Serdar Koçak, Mustafa Tekerli, Metin Erdoğan, Koray Çelikeloğlu, Ebubekir Yazıcı, Zehra Bozkurt, Özlem Hacan, Mustafa Demirtaş, and Samet Çinkaya
Arch. Anim. Breed., 67, 207–216, https://doi.org/10.5194/aab-67-207-2024, https://doi.org/10.5194/aab-67-207-2024, 2024
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It was detected that Texel and myostatin-carrying BC1 lambs were significantly higher than Pırlak and non-carrying BC1 lambs in the MLD area at weaning. Myostatin-carrying BC1 lambs had a superiority to Pırlak lambs in terms of muscle conformation and fatness of the hind leg. Myostatin-carrying BC1 lambs were found to be better than Pırlak in growth performance. It was concluded that the Pırlak lambs may be improved by introgression of myostatin mutation.
Wei Wang, Yongjuan Wang, Yufang Liu, Guiling Cao, Ran Di, Jinyu Wang, and Mingxing Chu
Arch. Anim. Breed., 66, 411–419, https://doi.org/10.5194/aab-66-411-2023, https://doi.org/10.5194/aab-66-411-2023, 2023
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In this study, GLUD1 single nucleotide polymorphisms (SNPs) were analyzed in early-puberty goats and delayed-puberty goat breeds by sequencing and restriction fragment length polymorphism (RFLP). The present study aimed to find genetic markers related to sexual precocity and high fertility in goats and to provide a scientific basis for marker-assisted early selection of reproductive performance.
Zühal Gündüz and Osman Biçer
Arch. Anim. Breed., 66, 369–378, https://doi.org/10.5194/aab-66-369-2023, https://doi.org/10.5194/aab-66-369-2023, 2023
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The Kilis goat has emerged as a breed with a unique genetic profile that reflects its complex ancestry due to historical crossbreeding between the Damascus and Hair goat populations in Türkiye. The Kilis goat is well adapted to arid areas and is known for its high milk yield. Therefore, it holds great potential for milk production and genetic improvement programs in Türkiye. For this reason, some genes that affect milk yield were investigated.
Kunlong Qi, Yaqing Dou, Chenlei Li, Yingke Liu, Chenglei Song, Xinjian Li, Kejun Wang, Ruimin Qiao, Xiuling Li, Feng Yang, and Xuelei Han
Arch. Anim. Breed., 66, 285–298, https://doi.org/10.5194/aab-66-285-2023, https://doi.org/10.5194/aab-66-285-2023, 2023
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With the rapid development of sequencing technology, it has been found that circRNAs play an important role in skeletal muscle development. During the growth and development of livestock, the growth and development of muscle fibers are closely related to the number, proliferation, and differentiation capacity of skeletal muscle satellite cells, thereby affecting meat quality. Notably, more and more studies now suggest that changes in circRNA expression may be associated with meat quality.
Dwi Lestari, Sri Murtini, Niken Ulupi, Asep Gunawan, and Cece Sumantri
Arch. Anim. Breed., 66, 275–283, https://doi.org/10.5194/aab-66-275-2023, https://doi.org/10.5194/aab-66-275-2023, 2023
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IPB-D2 chickens are one of the local Indonesian chickens that are being developed today. IPB-D2 chickens have disease-resistant traits. Selection is not only carried out conventionally but is also developed by molecular selection methods. By utilizing gene diversity in the major histocompatibility complex gene group, it was found that there were several single-nucleotide polymorphisms in the B Locus Beta 2 gene significantly associated with immunoglobulin Y concentrations in IPB-D2 chickens.
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Short summary
Finding polymorphisms of genes can provide potential molecular genetic markers for sheep reproduction. This study investigated the polymorphisms of three major reproductive genes (BMPR1B, BMP15 and GDF9) in Chinese sheep and found that BMPR1B and GDF9 might be the major genes influencing the reproductive performance of Chinese sheep breeds. This result might contribute to improving the prolificacy traits of native Chinese sheep in the future.
Finding polymorphisms of genes can provide potential molecular genetic markers for sheep...
