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The expression and polymorphism of the BMPR1B gene associated with litter size in small-tail Han (STH) sheep were determined. We found that BMPR1B was mainly expressed in reproduction-related tissues and was more highly expressed in the hypothalamus of polytocous than in monotocous ewes in the follicular and luteal phases. A new molecular marker was found and was negatively correlated with litter size in STH sheep. These results can provide a reference for selective sheep breeding.
AAB | Articles | Volume 64, issue 1
Arch. Anim. Breed., 64, 211–221, 2021
https://doi.org/10.5194/aab-64-211-2021
Arch. Anim. Breed., 64, 211–221, 2021
https://doi.org/10.5194/aab-64-211-2021

Original study 28 May 2021

Original study | 28 May 2021

The expression and mutation of BMPR1B and its association with litter size in small-tail Han sheep (Ovis aries)

Yu-Liang Wen et al.

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Cited articles

Abdoli, R., Mirhoseini, S. Z., Hossein Zadeh, N. G., and Zamani, P.: Screening for Causative Mutations of Major Prolificacy Genes in Iranian Fat-Tailed Sheep, Int. J. Fertil. Steril., 12, 51–55, https://doi.org/10.22074/ijfs.2018.5247, 2018. 
Abdurahman, A., Du, X., Yao, Y. L., Sulaiman, Y. M., Aniwashi, J., and Li, Q. F.: Smad4 Feedback Enhances BMPR1B Transcription in Ovine Granulosa Cells. Int. J. Mol. Sci., 20, 2732, https://doi.org/10.3390/ijms20112732, 2019. 
Aquino Martínez, R., Artigas, N., Gámez, B., Rosa, J. L., and Ventura, F.: Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling, PLoS ONE, 12, e178158, https://doi.org/10.1371/journal.pone.0178158, 2017. 
Chen, W. H., Tian, Z. L., Ma, L., Gan, S. Q., Sun, W., and Chu, M. X.: Expression analysis of BMPR1B, BMP15, GDF9, Smad1, Smad5, and Smad9 in rams with different fecundity, Pak. J. Zool., 52, 1665–1674, https://doi.org/10.17582/journal.pjz/20190226030219, 2020. 
Chen, X. Y., Sun, H. X., Tian, S. J., Xiang, H., Zhou, L. S., Dun, W. T., and Zhao, X. B.: Increasing litter size in a sheep breed by marker-assisted selection of BMPR1B A746G mutation, J. Genet., 94, 139–142, https://doi.org/10.1007/s12041-015-0470-8, 2015. 
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Short summary
The expression and polymorphism of the BMPR1B gene associated with litter size in small-tail Han (STH) sheep were determined. We found that BMPR1B was mainly expressed in reproduction-related tissues and was more highly expressed in the hypothalamus of polytocous than in monotocous ewes in the follicular and luteal phases. A new molecular marker was found and was negatively correlated with litter size in STH sheep. These results can provide a reference for selective sheep breeding.
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