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Volume 59, issue 1
Arch. Anim. Breed., 59, 37–43, 2016
https://doi.org/10.5194/aab-59-37-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.
Arch. Anim. Breed., 59, 37–43, 2016
https://doi.org/10.5194/aab-59-37-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.

Original study 25 Jan 2016

Original study | 25 Jan 2016

The expression of the SCD1 gene and its correlation with fattening and carcass traits in sheep

K. Ropka-Molik1, J. Knapik2, M. Pieszka3, and T. Szmatoła1 K. Ropka-Molik et al.
  • 1Department of Genomics and Animal Molecular Biology, National Research Institute of Animal Production, 32-083 Balice, Poland
  • 2Department of Animal Genetics and Breeding, National Research Institute of Animal Production, 32-083 Balice, Poland
  • 3Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, 32-083 Balice, Poland

Abstract. Stearoyl-CoA desaturase 1 (SCD1) is a critical enzyme that catalyzes the synthesis of monounsaturated fatty acids and is involved in several signaling pathways related to lipid metabolism. The objective of the present study was to estimate the expression of the SCD1 gene in three different ovine tissues strongly associated with lipid homeostasis. The SCD1 gene expression measurement was performed on three tissues (liver, subcutaneous fat, perirenal fat) originated from 15 old-type Polish Merino sheep. The SCD1 transcript abundance was evaluated based on the two most stable endogenous controls (RPS2 – ribosomal protein S2; ATP5G2 – H(+)-transporting ATP synthase). The highest expression of the SCD1 gene was observed in ovine subcutaneous fat compared to perirenal fat and liver. Furthermore, the present research indicated the significant correlation between ovine SCD1 transcript abundance and several important production traits. The expression of the SCD1 gene in liver and perirenal fat highly positively correlated with the feed : gain ratio, test of daily gain and age of the animals at slaughter. Moreover, in both tissues, the SCD1mRNA level positively correlated with weight and content of perirenal fat and subcutaneous fat (R =  0.64, 0.8, 0.6, respectively) and negatively with assessment of external fat content with the use of the EUROP scale (R = −0.64). The SCD1 expression in subcutaneous fat also corresponds with back fat of blade chop and thickness of longissimus dorsi muscles evaluated using USG (ultrasonography) (R =  −0.6 and 0.62, respectively). The significant correlation between SCD1 transcript abundance and fattening and slaughtering traits indicate the ability to improve important production traits in sheep via modification of expression of the SCD1 gene.

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Stearoyl-CoA desaturase 1 is a critical enzyme that catalyzes the synthesis of monounsaturated fatty acids. The objective of the present study was to evaluate the level of mRNA of SCD1 gene in three different ovine tissues strongly associated with lipid homeostasis. The significant correlation between SCD1 transcript abundance and fattening and slaughtering traits (fatness traits) indicates the ability to improve important production traits in sheep via modification of expression of SCD1 gene.
Stearoyl-CoA desaturase 1 is a critical enzyme that catalyzes the synthesis of monounsaturated...
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