Articles | Volume 67, issue 2
https://doi.org/10.5194/aab-67-153-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-67-153-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Polymorphisms of the HRG, FETUB, and GUCY1A1 genes and their association with litter size in sheep
Zizhen Ren
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Xiaoyun He
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Xiangyu Wang
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Mingxing Chu
CORRESPONDING AUTHOR
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
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Jinxin Wang, Yufang Liu, Siwu Guo, Ran Di, Xiangyu Wang, Xiaoyun He, and Mingxing Chu
Arch. Anim. Breed., 67, 51–60, https://doi.org/10.5194/aab-67-51-2024, https://doi.org/10.5194/aab-67-51-2024, 2024
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Finding polymorphisms of genes can provide potential molecular genetic markers for sheep reproduction. This study investigated the polymorphisms of three major reproductive genes (BMPR1B, BMP15 and GDF9) in Chinese sheep and found that BMPR1B and GDF9 might be the major genes influencing the reproductive performance of Chinese sheep breeds. This result might contribute to improving the prolificacy traits of native Chinese sheep in the future.
Si Chen, Lin Tao, Xiaoyun He, Ran Di, Xiangyu Wang, and Mingxing Chu
Arch. Anim. Breed., 64, 475–486, https://doi.org/10.5194/aab-64-475-2021, https://doi.org/10.5194/aab-64-475-2021, 2021
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Qi Han, Xiaoyun He, Ran Di, and Mingxing Chu
Arch. Anim. Breed., 64, 457–466, https://doi.org/10.5194/aab-64-457-2021, https://doi.org/10.5194/aab-64-457-2021, 2021
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Our results suggest that estrous cycles may be associated with clock gene expression in the Small-tailed Han sheep (STH sheep). This is the first study to systematically analyze the expression patterns of clock genes of different estrous cycles in ewes, which could form a basis for further studies to develop the relationship between clock genes and the estrous cycle.
Ying-Jie Zhong, Yang Yang, Xiang-Yu Wang, Ran Di, Ming-Xing Chu, and Qiu-Yue Liu
Arch. Anim. Breed., 64, 131–138, https://doi.org/10.5194/aab-64-131-2021, https://doi.org/10.5194/aab-64-131-2021, 2021
Qing Xia, Xiangyu Wang, Zhangyuan Pan, Rensen Zhang, Caihong Wei, Mingxing Chu, and Ran Di
Arch. Anim. Breed., 64, 7–16, https://doi.org/10.5194/aab-64-7-2021, https://doi.org/10.5194/aab-64-7-2021, 2021
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The objective was to assess the genetic diversity and phylogenetic relationship of nine sheep populations. Overall, these sheep populations in the study exhibited a rich genetic diversity. The nine sheep populations can be divided into two groups. SUF and DST were clustered in one group, and GMM–BAS–BAM, HUS–STH and DOS–DOP were divided into three clusters. This clustering result is consistent with sheep breeding history. TreeMix analysis also hinted at the possible gene flow from GMM to SUF.
Qing Xia, Ran Di, Xiao-Yun He, Cai-Hong Wei, and Ming-Xing Chu
Arch. Anim. Breed., 63, 451–460, https://doi.org/10.5194/aab-63-451-2020, https://doi.org/10.5194/aab-63-451-2020, 2020
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The expression patterns of the HPG axis-related genes in rams were analyzed using qPCR. It showed that DIO2 and KISS1 were mainly expressed in pituitary and hypothalamus in both breeds, respectively. EYA3 and GPR54 were widely expressed in both breeds, with significant differences in testis and vas deferens. We speculated that the four genes may regulate the estrous mode in different regions in rams. This is the first study to analyze the expression patterns of HPG axis-related genes in rams.
Related subject area
Reproduction
Expression of peroxiredoxin-6 in the epididymal microenvironment and sperm of sheep
N-acetylcysteine may improve endometrial receptivity by modulating endometrial stromal cells in goats
Improvement of ram semen quality by luteolin enrichment during cold preservation
Effect of protected fatty acid supplementation on ovarian activity, reproductive hormone profiles and reproduction of Barki ewes under semiarid conditions
Association analysis of single nucleotide polymorphisms in the sheep FecB gene with reproductive and body size performance
Effect of water quality on causes of calf mortality in cattle-farm-associated epidemics
Impact of redox status of donor cows before superovulation treatment on in vivo embryo production
Detection of genetic variations in the GDF9 and BMP15 genes in Kazakh meat–wool sheep
Determination of the effect of pre-mating weight and placental characteristics on birth weight in Karayaka sheep
Lin28B overexpression decreases let-7b and let-7g levels and increases proliferation and estrogen secretion in Dolang sheep ovarian granulosa cells
Jiaoxia Xu, Jian Zhang, Yukun Song, Gaowa Hasi, Zhaojin Luan, Wei Du, and Jiaxin Zhang
Arch. Anim. Breed., 67, 393–399, https://doi.org/10.5194/aab-67-393-2024, https://doi.org/10.5194/aab-67-393-2024, 2024
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Peroxiredoxin-6 (PRDX6) is expressed in the epididymal tissue, epididymal fluid, and epididymal sperm of sheep. As the sperm mature and transit through the epididymis, the intracellular distribution of PRDX6 gradually becomes more extensive. This suggests that PRDX6 has an important role in promoting sperm maturation.
Kaibin Fu, Xiang Chen, Xingzhou Tian, Wen Tang, Ting Gong, Yan Zhang, and Taotao Ji
Arch. Anim. Breed., 67, 361–372, https://doi.org/10.5194/aab-67-361-2024, https://doi.org/10.5194/aab-67-361-2024, 2024
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We used endometrial stromal cells of Qianbei Ma goats as our study subjects and found that N-acetylcysteine could promote the proliferation of endometrial stromal cells and increase the viability, antioxidant activity, mitochondrial membrane potential and expression of endometrial receptivity marker genes of endometrial stromal cells, which suggests that N-acetylcysteine may be beneficial in improving endometrial receptivity of goats.
Sharif Khozein, Mohsen Eslami, and Farhad Farrokhi-Ardabili
Arch. Anim. Breed., 67, 123–132, https://doi.org/10.5194/aab-67-123-2024, https://doi.org/10.5194/aab-67-123-2024, 2024
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The current study was designed to evaluate the probable protective effect of luteolin against lipid peroxidation of ram spermatozoa membranes and kinematics during cold preservation. Results indicated that luteolin was able to improve the kinematics of spermatozoa during liquid storage. Enzymatic and total antioxidants were improved by luteolin enrichment. Luteolin did not affect the nitrosative index of stored ram spermatozoa after 72 h.
Bahaa Farrag, Khalid Ahmed El-Bahrawy, Hesham Attia Shedeed, and Muhammed Ahmed-Hilmy El-Rayes
Arch. Anim. Breed., 67, 111–122, https://doi.org/10.5194/aab-67-111-2024, https://doi.org/10.5194/aab-67-111-2024, 2024
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Our study suggests that dietary supplementation in Barki ewes prior to mating is effective in maintaining reproductive performance. This improvement is evident through increased levels of hormonal profiles, numbers and sizes of ovarian follicles, improved conception, and lambing rates. In fact, the effects of protected fats are most pronounced when combined with hormonal treatments.
Lingchao Kong, Shuaitong Li, Yuan Pan, Jiaqi Li, Siyi Li, Yining Liu, Sibing Hou, Qingkun Liu, Yanjun Qiao, Yinggang Sun, and Zeying Wang
Arch. Anim. Breed., 67, 81–95, https://doi.org/10.5194/aab-67-81-2024, https://doi.org/10.5194/aab-67-81-2024, 2024
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In this study, we investigated the effect of the sheep FecB gene on reproductive and productive performance by molecular biology techniques. Our results showed that the most dominant genotypes associated with lambing performance were AA and CT, with the dominant haplotype combination being AACT. In terms of body performance, the dominant genotypes were AA and CC, with the dominant haplotype combination being AACC.
Mohammed A. Kamal, Mahmoud A. Khalf, Zakia A. M. Ahmed, Jakeen A. Eljakee, Rashed A. Alhotan, Mohammed A. A. Al-Badwi, Elsayed O. Hussein, Branislav Galik, and Ahmed A. Saleh
Arch. Anim. Breed., 67, 25–35, https://doi.org/10.5194/aab-67-25-2024, https://doi.org/10.5194/aab-67-25-2024, 2024
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Poor-quality drinking water plays a detrimental role in the suppression of calf immunity, giving rise to an increased rate of calf mortality. The present study aims to evaluate the causes of calf mortality in beef and dairy farms in relation to drinking water quality (DWQ). We could conclude that DWQ highly affects causes of calf mortality, but we cannot exclude some farm hygienic risk factors.
Shogo Hashimoto, Masayasu Taniguchi, Ayane Edo, Tetsushi Ono, Tetty Barunawati Siagian, Hiroaki Sekine, Megumi Nagahara, Takeshige Otoi, and Mitsuhiro Takagi
Arch. Anim. Breed., 66, 433–437, https://doi.org/10.5194/aab-66-433-2023, https://doi.org/10.5194/aab-66-433-2023, 2023
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This study aimed to investigate the relationship between oxidation and antioxidation parameters before superovulation (SOV) treatment and embryo recovery in donor cows. The redox status of donor cows before SOV treatment affects embryo recovery, as cows with high levels of both oxidative and antioxidative status have better embryo production. This information will be useful for the selection of donor cows and subsequent treatments.
Makpal Amandykova, Zarina Orazymbetova, Tilek Kapassuly, Altynay Kozhakhmet, Saltanat Khamzina, Kairat Iskakov, and Kairat Dossybayev
Arch. Anim. Breed., 66, 401–409, https://doi.org/10.5194/aab-66-401-2023, https://doi.org/10.5194/aab-66-401-2023, 2023
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Sheep breeding is one of the leading livestock sectors in agricultural countries, including Kazakhstan. A comprehensive study of the genetic aspects of these animals will solve many issues of the effectiveness of sheep breeding. This is important for such little-studied breeds as the Kazakh meat–wool sheep breed, which are multifetal. In this study, for the first time, we characterized this breed by looking at fecundity genes and found mutations that positively affect sheep fertility.
Samet Urun and Emre Şirin
Arch. Anim. Breed., 66, 335–340, https://doi.org/10.5194/aab-66-335-2023, https://doi.org/10.5194/aab-66-335-2023, 2023
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The aim of this work was to determine the effect of the pre-mating weight (PMW) and placental characteristics on the birth weight (BW). Although prior studies have determined a relationship between BW and placental characteristics, no existing work has determined a relationship between the PMW and BW. This is also the first study in which placental surface area is used as a factor for determining the relationship between placental characteristics and BW.
Zhiyuan Sui, Yongjie Zhang, Zhishuai Zhang, Chenguang Wang, Xiaojun Li, and Feng Xing
Arch. Anim. Breed., 66, 217–224, https://doi.org/10.5194/aab-66-217-2023, https://doi.org/10.5194/aab-66-217-2023, 2023
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There are few studies investigating the RNA-binding protein Lin28B and ovine puberty. This study focuses on understanding how its overexpression changes microRNA levels, cell proliferation, and estrogen secretion. To assess these changes, we used quantitative real-time (qRT) PCR, overexpression vectors, and ELISA. We found that Lin28B overexpression decreases let-7b and let-7g levels and increases granulosa cell proliferation and their estrogen secretion.
Cited articles
Banerjee, P., Jana, S. K., Pasricha, P., Ghosh, S., Chakravarty, B., and Chaudhury, K.: Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage, Fertil. Steril., 99, 179–187, https://doi.org/10.1016/j.fertnstert.2012.08.034, 2013.
Binsila, B. K., Archana, S. S., Ramya, L., Swathi, D., Selvaraju, S., Gowda, N. K. S., Pal, D. T., Rafay, A., and Bhatta, R.: Elucidating the processes and pathways enriched in buffalo sperm proteome in regulating semen quality, Cell Tissue Res., 383, 881–903, https://doi.org/10.1007/s00441-020-03303-9, 2021.
Burkart, A. D., Xiong, B., Baibakov, B., Jimenez-Movilla, M., and Dean, J.: Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy, J. Cell Biol., 197, 37–44, https://doi.org/10.1083/jcb.201112094, 2012.
Cao, X. L., Song, J. Y., and Sun, Z. G.: Quantitative label-free proteomic analysis of human follicle fluid to identify novel candidate protein biomarker for endometriosis-associated infertility, J. Proteomics, 266, 104680, https://doi.org/10.1016/j.jprot.2022.104680, 2022.
Curtis, D.: Analysis of 200,000 exome-sequenced UK biobank subjects implicates genes involved in increased and decreased risk of hypertension, Pulse (Basel), 9, 17–29, https://doi.org/10.1159/000517419, 2021.
Denecke, B., Graber, S., Schafer, C., Heiss, A., Woltje, M., and Jahnen-Dechent, W.: Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A, Biochem. J., 376, 135–145, https://doi.org/10.1042/BJ20030676, 2003.
Dietzel, E., Wessling, J., Floehr, J., Schafer, C., Ensslen, S., Denecke, B., Rosing, B., Neulen, J., Veitinger, T., Spehr, M., Tropartz, T., Tolba, R., Renne, T., Egert, A., Schorle, H., Gottenbusch, Y., Hildebrand, A., Yiallouros, I., Stocker, W., Weiskirchen, R., and Jahnen-Dechent, W.: Fetuin-B, a liver-derived plasma protein is essential for fertilization, Dev. Cell, 25, 106–112, https://doi.org/10.1016/j.devcel.2013.03.001, 2013.
Elenis, E., Lindgren, K. E., Karypidis, H., Skalkidou, A., Hosseini, F., Bremme, K., Landgren, B. M., Skjoldebrand-Sparre, L., Stavreus-Evers, A., Sundstrom-Poromaa, I., and Akerud, H.: The histidine-rich glycoprotein A1042G polymorphism and recurrent miscarriage: a pilot study, Reprod. Biol. Endocrin., 12, 70, https://doi.org/10.1186/1477-7827-12-70, 2014.
Felici, M. D., Salustri, A., and Siracusa, G.: “Spontaneous” hardening of the zona pellucida of mouse oocytes during in vitro culture. ii. the effect of follicular fluid and glycosaminoglycans, Gamete Res., 12, 227–235, https://doi.org/10.1002/mrd.1120120302, 1985.
Floehr, J., Dietzel, E., Neulen, J., Rosing, B., Weissenborn, U., and Jahnen-Dechent, W.: Association of high fetuin-B concentrations in serum with fertilization rate in IVF: a cross-sectional pilot study, Hum. Reprod , 31, 630–637, https://doi.org/10.1093/humrep/dev340, 2016.
Floehr, J., Dietzel, E., Schmitz, C., Chappell, A., and Jahnen-Dechent, W.: Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility, Mol. Hum. Reprod, 23, 34–44, https://doi.org/10.1093/molehr/gaw068, 2017.
Haupt, H. and Heimburger, N.: Human serum proteins with high affinity for carboxymethylcellulose. I. Isolation of lysozyme, C1q and 2 unknown-globulins, Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 353, 1125–1132, https://doi.org/10.1515/bchm2.1972.353.2.1125, 1972.
He, X., Zhang, Z., Liu, Q., and Chu, M.: Polymorphisms of the melatonin receptor 1A gene that affects the reproductive seasonality and litter size in Small Tail Han sheep, Reprod. Domest. Anim., 54, 1400–1410, https://doi.org/10.1111/rda.13538, 2019.
Jin, B. L., Niu, Z. H., and Feng, Y.: Polymorphism of histidine-rich glycoprotein affected ovarian response in Chinese women: a pilot study, J. Reprod. Med., 24, 850–854, https://doi.org/10.3969/j.issn.1004-3845.2015.10.018, 2015.
Jones, A. L., Hulett, M. D., and Parish, C. R.: Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems, Immunol. Cell Biol., 83, 106–118, https://doi.org/10.1111/j.1440-1711.2005.01320.x, 2005.
Jung, S. H., Won, K., Lee, K. P., Kim, H. J., Seo, E. H., Lee, H. M., Park, E. S., Lee, S. H., and Kim, B.: The serum protein fetuin-B is involved in the development of acute myocardial infarction, Clin. Sci., 129, 27–38, https://doi.org/10.1042/CS20140462, 2015.
Karrlander, M., Lindberg, N., Olofsson, T., Kastemar, M., Olsson, A. K., and Uhrbom, L.: Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma, PLoS ONE, 4, e8536, https://doi.org/10.1371/journal.pone.0008536, 2009.
Kessler, T., Wobst, J., Wolf, B., Eckhold, J., Vilne, B., Hollstein, R., Von Ameln, S., Dang, T. A., Sager, H. B., Moritz Rumpf, P., Aherrahrou, R., Kastrati, A., Bjorkegren, J. L. M., Erdmann, J., Lusis, A. J., Civelek, M., Kaiser, F. J., and Schunkert, H.: Functional characterization of the GUCY1A3 coronary artery disease risk locus, Circulation, 136, 476–489, https://doi.org/10.1161/CIRCULATIONAHA.116.024152, 2017.
Koide, T. and Odani, S.: Histidine-rich glycoprotein is evolutionarily related to the cystatin superfamily. Presence of two cystatin domains in the N-terminal region, Febs. Lett., 216, 17–21, https://doi.org/10.1016/0014-5793(87)80748-2, 1987.
Kralisch, S., Hoffmann, A., Lossner, U., Kratzsch, J., Bluher, M., Stumvoll, M., Fasshauer, M., and Ebert, T.: Regulation of the novel adipokines/hepatokines fetuin A and fetuin B in gestational diabetes mellitus, Metab. Clin. Exp., 68, 88–94, https://doi.org/10.1016/j.metabol.2016.11.017, 2017.
Lash, G. E., Innes, B. A., Drury, J. A., Robson, S. C., Quenby, S., and Bulmer, J. N.: Localization of angiogenic growth factors and their receptors in the human endometrium throughout the menstrual cycle and in recurrent miscarriage, Hum. Reprod., 27, 183–195, https://doi.org/10.1093/humrep/der376, 2012.
Li, L., Cleary, S., Mandarano, M. A., Long, W., Birchmeier, C., and Jones, F. E.: The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland, Oncogene, 21, 4900–4907, https://doi.org/10.1038/sj.onc.1205634, 2002.
Lindgren, K. E., Karehed, K., Karypidis, H., Hosseini, F., Bremme, K., Landgren, B. M., Skjoldebrand-Sparre, L., Stavreus-Evers, A., Sundstrom-Poromaa, I., and Akerud, H.: Histidine-rich glycoprotein gene polymorphism in patients with recurrent miscarriage, Acta Obstet. Gyn. Scan., 92, 974–977, https://doi.org/10.1111/aogs.12155, 2013.
Liu, W., Fang, C., Ma, H., Liu, L., Wang, Q., Cao, H., Lv, S., Yu, Q., and Cao, X.: New guanylate cyclase 1 soluble subunit alpha 1 (GUCY1A1) gene-specific single nucleotide polymorphism (SNP) marker, useful for breeding of black sheep of Turpan, CN109735634-A, https://webofscience.clarivate.cn/wos/alldb/full-record/DIIDW:201945152Y (last access: 1 April 2024), 2019.
Ma, H., Fang, C., Liu, L., Wang, Q., Aniwashi, J., Sulaiman, Y., Abudilaheman, K., and Liu, W.: Identification of novel genes associated with litter size of indigenous sheep population in Xinjiang, China using specific-locus amplified fragment sequencing technology, PeerJ, 7, e8079, https://doi.org/10.7717/peerj.8079, 2019.
Malinowski, D., Zawadzka, M., Safranow, K., Drozdzik, M., and Pawlik, A.: SELL and GUCY1A1 gene polymorphisms in patients with unstable angina, Biomedicines, 10, 2494, https://doi.org/10.3390/biomedicines10102494, 2022.
McFee, R. M. and Cupp, A. S.: Vascular contributions to early ovarian development: potential roles of VEGFA isoforms, Reprod. Fertil. Dev., 25, 333–342, https://doi.org/10.1071/RD12134, 2013.
Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C., Burke, M., Goode, R. J., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., Greve, J. W., Rensen, S. S., Molloy, M. P., Lancaster, G. I., Bruce, C. R., and Watt, M. J.: Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism, Cell Metab., 22, 1078–1089, https://doi.org/10.1016/j.cmet.2015.09.023, 2015.
Nishibori, M.: Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19, J. Pharmacol. Sci, 150, 9–20, https://doi.org/10.1016/j.jphs.2022.06.001, 2022.
Nordqvist, S., Karehed, K., Hambiliki, F., Wanggren, K., Stavreus-Evers, A., and Akerud, H.: The presence of histidine-rich glycoprotein in the female reproductive tract and in embryos, Reprod. Sci., 17, 941–947, https://doi.org/10.1177/1933719110374366, 2010.
Nordqvist, S., Karehed, K., Stavreus-Evers, A., and Akerud, H.: Histidine-rich glycoprotein polymorphism and pregnancy outcome: a pilot study, Reprod. Biomed. Online, 23, 213–219, https://doi.org/10.1016/j.rbmo.2011.04.004, 2011.
Olivier, E., Soury, E., Ruminy, P., Husson, A., Parmentier, F., Daveau, M., and Salier, J. P.: Fetuin-B, a second member of the fetuin family in mammals, Biochem. J., 350, 589–597, https://doi.org/10.1042/bj3500589, 2000.
Pan, Y., Deng, L., Wang, H., He, K., and Xia, Q.: Histidine-rich glycoprotein (HRGP): Pleiotropic and paradoxical effects on macrophage, tumor microenvironment, angiogenesis, and other physiological and pathological processes, Genes Dis., 9, 381–392, https://doi.org/10.1016/j.gendis.2020.07.015, 2020.
Roca, J., Perez-Patino, C., Barranco, I., Padilla, L. C., Martinez, E. A., Rodriguez-Martinez, H., and Parrilla, I.: Proteomics in fresh and preserved pig semen: Recent achievements and future challenges, Theriogenology, 150, 41–47, https://doi.org/10.1016/j.theriogenology.2020.01.066, 2020.
Schroeder, A. C., Schultz, R. M., Kopf, G. S., Taylor, F. R., Becker, R. B., and Eppig, J. J.: Fetuin inhibits zona pellucida hardening and conversion of ZP2 to ZP2f during spontaneous mouse oocyte maturation in vitro in the absence of serum, Biol. Reprod., 43, 891–897, https://doi.org/10.1095/biolreprod43.5.891, 1990.
Simjak, P., Cinkajzlova, A., Anderlova, K., Klouckova, J., Kratochvilova, H., Lacinova, Z., Kavalkova, P., Krejci, H., Mraz, M., Parizek, A., Krsek, M., and Haluzik, M.: Changes in plasma concentrations and mRNA expression of hepatokines fetuin A, fetuin B and FGF21 in physiological pregnancy and gestational diabetes mellitus, Physiol. Res., 67, S531–S542, https://doi.org/10.33549/physiolres.934017, 2018.
Stocker, W., Karmilin, K., Hildebrand, A., Westphal, H., Yiallouros, I., Weiskirchen, R., Dietzel, E., Floehr, J., and Jahnen-Dechent, W.: Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B, J. Biol. Chem., 395, 1195–1199, https://doi.org/10.1515/hsz-2014-0189, 2014.
Tomonobu, N., Kinoshita, R., Wake, H., Inoue, Y., Ruma, I. M. W., Suzawa, K., Gohara, Y., Komalasari, N. L. G. Y., Jiang, F., Murata, H., Yamamoto, K. I., Sumardika, I. W., Chen, Y., Futami, J., Yamauchi, A., Kuribayashi, F., Kondo, E., Toyooka, S., Nishibori, M., and Sakaguchi, M.: Histidine-rich glycoprotein suppresses the S100A8/A9-mediated organotropic metastasis of melanoma cells, Int. J. Mol. Sci, 23, 10300, https://doi.org/10.3390/ijms231810300, 2022.
Tsuchida-Straeten, N., Ensslen, S., Schafer, C., Woltjeo, M., Denecke, B., Moser, M., Graber, S., Wakabayashi, S., Koide, T., and Jahnen-Dechent, W.: Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG), J. Thromb. Haemost., 3, 865–872, https://doi.org/10.1111/j.1538-7836.2005.01238.x, 2005.
Tugues, S., Honjo, S., Konig, C., Noguer, O., Hedlund, M., Botling, J., Deschoemaeker, S., Wenes, M., Rolny, C., Jahnen-Dechent, W., Mazzone, M., and Claesson-Welsh, L.: Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization, Cancer Res., 72, 1953–1963, https://doi.org/10.1158/0008-5472.CAN-11-2194, 2012.
UniProt Consortium: Activities at the Universal Protein Resource (UniProt), Nucleic Acids Res, 42, D191-198, https://doi.org/10.1093/nar/gkt1140, 2014.
Wakabayashi, S.: New insights into the functions of histidine-rich glycoprotein, Int. Rev. Cel. Mol. Bio., 304, 467–493, https://doi.org/10.1016/B978-0-12-407696-9.00009-9, 2013.
Zhang, R., Cheng, F., Cheng, W., Wang, X., Zhang, B., Tian, M., Li, K., and Liu, D.: The Relationships among Plasma Fetuin-B, Thyroid Autoimmunity, and Fertilization Rate In Vitro Fertilization and Embryo Transfer, Int. J. Endocrinol, 2022, 9961253, https://doi.org/10.1155/2022/9961253, 2022.
Zhang, S., Tong, X., Zhang, Y., and Sun, X.: Early warning based on follicular fluid histidine-rich glycoprotein, C4b binding protein expression level as unexplained recurrent abortion, comprises e.g. collecting follicular fluid, centrifuging, taking supernatant, packaging, freezing, testing follicular fluid, counting and analyzing result, CN113791224-A, https://webofscience.clarivate.cn/wos/alldb/full-record/DIIDW:2022215010 (last access: 1 April 2024), 2021.
Zhu, K., Wang, Y., Shu, P., Zhou, Q., Zhu, J., Zhou, W., Du, C., Xu, C., Liu, X., and Tang, L.: Increased serum levels of fetuin B in patients with coronary artery disease, Endocr. Rev., 58, 97–105, https://doi.org/10.1007/s12020-017-1387-1, 2017.
Zhu, W., Zhang, Y., Ren, C.H., Cheng, X., Chen, J. H., Ge, Z. Y., Sun, Z. P., Zhuo, X., Sun, F. F., Chen, Y. L., Jia, X. J., and Zhang, Z.: Identification of proteomic markers for ram spermatozoa motility using a tandem mass tag (TMT) approach, J. Proteomics, 210, 103438, https://doi.org/10.1016/j.jprot.2019.103438, 2020.
Short summary
The g.405442728A>G locus of HRG exhibited moderate polymorphism (0.25<PIC<0.5) in these breeds, indicating this locus has great selection potential. It is accurate to say HRG can be used as a molecular marker to increase litter size in Small-tailed Han sheep (STH). The g.405442728A>G locus of HRG and the g.421655951C>T locus of FETUB had a significant effect on litter size in STH (P<0.05). We can use HRG and FETUB as candidate genes for the selection of litter size in sheep breeding.
The g.405442728A>G locus of HRG exhibited moderate polymorphism (0.25<PIC<0.5) in these breeds,...