Articles | Volume 67, issue 2
Original study
11 Apr 2024
Original study |  | 11 Apr 2024

Polymorphisms of the HRG, FETUB, and GUCY1A1 genes and their association with litter size in sheep

Zizhen Ren, Xiaoyun He, Xiangyu Wang, and Mingxing Chu

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Cited articles

Banerjee, P., Jana, S. K., Pasricha, P., Ghosh, S., Chakravarty, B., and Chaudhury, K.: Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage, Fertil. Steril., 99, 179–187,, 2013. 
Binsila, B. K., Archana, S. S., Ramya, L., Swathi, D., Selvaraju, S., Gowda, N. K. S., Pal, D. T., Rafay, A., and Bhatta, R.: Elucidating the processes and pathways enriched in buffalo sperm proteome in regulating semen quality, Cell Tissue Res., 383, 881–903,, 2021. 
Burkart, A. D., Xiong, B., Baibakov, B., Jimenez-Movilla, M., and Dean, J.: Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy, J. Cell Biol., 197, 37–44,, 2012. 
Cao, X. L., Song, J. Y., and Sun, Z. G.: Quantitative label-free proteomic analysis of human follicle fluid to identify novel candidate protein biomarker for endometriosis-associated infertility, J. Proteomics, 266, 104680,, 2022. 
Curtis, D.: Analysis of 200,000 exome-sequenced UK biobank subjects implicates genes involved in increased and decreased risk of hypertension, Pulse (Basel), 9, 17–29,, 2021. 
Short summary
The g.405442728A>G locus of HRG exhibited moderate polymorphism (0.25<PIC<0.5) in these breeds, indicating this locus has great selection potential. It is accurate to say HRG can be used as a molecular marker to increase litter size in Small-tailed Han sheep (STH). The g.405442728A>G locus of HRG and the g.421655951C>T locus of FETUB had a significant effect on litter size in STH (P<0.05). We can use HRG and FETUB as candidate genes for the selection of litter size in sheep breeding.