Articles | Volume 65, issue 3
https://doi.org/10.5194/aab-65-293-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-65-293-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original study
| 
05 Aug 2022
Original study |
| 05 Aug 2022
| 05 Aug 2022
Genetic variation in the ovine KAP22-1 gene and its effect on wool traits in Egyptian sheep
Animal and Poultry Division, Desert Research Center, 1st
Mathaf El-Mataryia, 11735, Cairo, Egypt
Aymen A. Gad-Allah
Department of Wool Technology and Production, Desert
Research Center, 1st Mathaf El-Mataryia, 11735, Cairo, Egypt
Essam M. Albetar
Department of Wool Technology and Production, Desert
Research Center, 1st Mathaf El-Mataryia, 11735, Cairo, Egypt
Related subject area
Subject: DNA markers and gene expressions | Animal: Sheep
Genetic polymorphism of the ovine MAP3K5 gene and its association with body size traits in Hu sheep of China
Comparison of expression patterns of six canonical clock genes of follicular phase and luteal phase in Small-tailed Han sheep
Trehalose can effectively protect sheep epididymis epithelial cells from oxidative stress
The expression and mutation of BMPR1B and its association with litter size in small-tail Han sheep (Ovis aries)
Molecular mechanisms of fat deposition: IL-6 is a hub gene in fat lipolysis, comparing thin-tailed with fat-tailed sheep breeds
Genetic diversity and phylogenetic relationship of nine sheep populations based on microsatellite markers
Expression analysis of DIO2, EYA3, KISS1 and GPR54 genes in year-round estrous and seasonally estrous rams
Assessment of genetic diversity and differentiation among four indigenous Turkish sheep breeds using microsatellites
Assessment of genetic diversity in main local sheep breeds from Romania using microsatellite markers
Associations of ORMDL1 gene copy number variations with growth traits in four Chinese sheep breeds
Selection signature analysis reveals genes underlying sheep milking performance
Identification of the association between FABP4 gene polymorphisms and milk production traits in Sfakia sheep
Identification of genomic regions and candidate genes of functional importance for gastrointestinal parasite resistance traits in Djallonké sheep of Burkina Faso
The novel T755C mutation in BMP15 is associated with the litter size of Iranian Afshari, Ghezel, and Shal breeds
Nutritional modification of SCD, ACACA and LPL gene expressions in different ovine tissues
Using microsatellite markers to analyze genetic diversity in 14 sheep types in Iran
Effect of the IGF-I gene polymorphism on growth, body size, carcass and meat quality traits in Coloured Polish Merino sheep
A novel 29 bp insertion/deletion (indel) variant of the LHX3 gene and its influence on growth traits in four sheep breeds of various fecundity
Effect of purmorphamine on the mRNA expression of Sonic Hedgehog signaling downstream molecules in ovine embryo
The expression of the SCD1 gene and its correlation with fattening and carcass traits in sheep
Xiaobin Yang, Weimin Wang, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Liming Zhao, Jianghui Wang, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin, Xiwen Zeng, Rui Zhai, Zongwu Ma, Jia Liu, Panpan Cui, and Xiaoxue Zhang
Arch. Anim. Breed., 66, 71–79, https://doi.org/10.5194/aab-66-71-2023, https://doi.org/10.5194/aab-66-71-2023, 2023
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The demand for mutton is increasing yearly. Sheep were raised to 180 d of age, and production performance was measured and recorded at 20-d intervals from 80 to 180 d. The sheep were then slaughtered at 180 d of age. Blood, tissues, and other samples were collected for follow-up experimental research. Finally, we detected a mutation site in a specific segment of the ovine MAP3K5 gene, and this site can be used as a molecular genetic marker to improve sheep body size traits.
Qi Han, Xiaoyun He, Ran Di, and Mingxing Chu
Arch. Anim. Breed., 64, 457–466, https://doi.org/10.5194/aab-64-457-2021, https://doi.org/10.5194/aab-64-457-2021, 2021
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Our results suggest that estrous cycles may be associated with clock gene expression in the Small-tailed Han sheep (STH sheep). This is the first study to systematically analyze the expression patterns of clock genes of different estrous cycles in ewes, which could form a basis for further studies to develop the relationship between clock genes and the estrous cycle.
Zhaojin Luan, Xiaomei Fan, Yongchao Zhao, Huizi Song, Wei Du, Jiaoxia Xu, Zhaochen Wang, Wenguang Zhang, and Jiaxin Zhang
Arch. Anim. Breed., 64, 335–343, https://doi.org/10.5194/aab-64-335-2021, https://doi.org/10.5194/aab-64-335-2021, 2021
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In this work, we analyzed the effects of trehalose on sheep EEC proliferation and possible mechanisms affecting its role. Our study suggested that exogenous trehalose exhibits antioxidant activity through increasing the activities of CAT, GSH-Px, and the expression level of GPX5. The cell line cultured provides a strong resource for elucidating the transcriptional networks that coordinate functions of sheep epididymis epithelium and have greatly enhanced our understanding of epididymis biology.
Yu-Liang Wen, Xiao-Fei Guo, Lin Ma, Xiao-Sheng Zhang, Jin-Long Zhang, Sheng-Guo Zhao, and Ming-Xing Chu
Arch. Anim. Breed., 64, 211–221, https://doi.org/10.5194/aab-64-211-2021, https://doi.org/10.5194/aab-64-211-2021, 2021
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The expression and polymorphism of the BMPR1B gene associated with litter size in small-tail Han (STH) sheep were determined. We found that BMPR1B was mainly expressed in reproduction-related tissues and was more highly expressed in the hypothalamus of polytocous than in monotocous ewes in the follicular and luteal phases. A new molecular marker was found and was negatively correlated with litter size in STH sheep. These results can provide a reference for selective sheep breeding.
Sana Farhadi, Jalil Shodja Ghias, Karim Hasanpur, Seyed Abolghasem Mohammadi, and Esmaeil Ebrahimie
Arch. Anim. Breed., 64, 53–68, https://doi.org/10.5194/aab-64-53-2021, https://doi.org/10.5194/aab-64-53-2021, 2021
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The mechanism of lipid metabolism is complex, and the manipulation of fat storage for lean meat production is very important in the sheep-breeding industry. The present study aimed to study the genetic profiles of fat tissues and to discover the diversity in the genetic mechanisms defining fat deposition between two morphologically different sheep breeds. Analysis of the diversity of fat deposition may aid the recognition of genes and pathways responsible for the formation of tail fat.
Qing Xia, Xiangyu Wang, Zhangyuan Pan, Rensen Zhang, Caihong Wei, Mingxing Chu, and Ran Di
Arch. Anim. Breed., 64, 7–16, https://doi.org/10.5194/aab-64-7-2021, https://doi.org/10.5194/aab-64-7-2021, 2021
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The objective was to assess the genetic diversity and phylogenetic relationship of nine sheep populations. Overall, these sheep populations in the study exhibited a rich genetic diversity. The nine sheep populations can be divided into two groups. SUF and DST were clustered in one group, and GMM–BAS–BAM, HUS–STH and DOS–DOP were divided into three clusters. This clustering result is consistent with sheep breeding history. TreeMix analysis also hinted at the possible gene flow from GMM to SUF.
Qing Xia, Ran Di, Xiao-Yun He, Cai-Hong Wei, and Ming-Xing Chu
Arch. Anim. Breed., 63, 451–460, https://doi.org/10.5194/aab-63-451-2020, https://doi.org/10.5194/aab-63-451-2020, 2020
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The expression patterns of the HPG axis-related genes in rams were analyzed using qPCR. It showed that DIO2 and KISS1 were mainly expressed in pituitary and hypothalamus in both breeds, respectively. EYA3 and GPR54 were widely expressed in both breeds, with significant differences in testis and vas deferens. We speculated that the four genes may regulate the estrous mode in different regions in rams. This is the first study to analyze the expression patterns of HPG axis-related genes in rams.
Bahar Argun Karsli, Eymen Demir, Huseyin Goktug Fidan, and Taki Karsli
Arch. Anim. Breed., 63, 165–172, https://doi.org/10.5194/aab-63-165-2020, https://doi.org/10.5194/aab-63-165-2020, 2020
Andreea Dudu, Gina-Oana Popa, Elena Ghiță, Rodica Pelmuș, Cristina Lazăr, Marieta Costache, and Sergiu E. Georgescu
Arch. Anim. Breed., 63, 53–59, https://doi.org/10.5194/aab-63-53-2020, https://doi.org/10.5194/aab-63-53-2020, 2020
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The state of local breeds is precarious worldwide because of the introduction of breeds with improved traits. Our study analyzes the genetic variation of four Romanian local sheep breeds using nuclear DNA markers. Tsurcana and Tsigai showed an intense gene flow among them and were less differentiated than Ratska and Teleorman Blackhead. The results of this study may be useful for breeding programs and conservation plans since the genetic resources of the local breeds must be preserved.
Xiaogang Wang, Xiukai Cao, Yifan Wen, Yilei Ma, Ibrahim Elsaeid Elnour, Yongzhen Huang, Xianyong Lan, Buren Chaogetu, Linyong Hu, and Hong Chen
Arch. Anim. Breed., 62, 571–578, https://doi.org/10.5194/aab-62-571-2019, https://doi.org/10.5194/aab-62-571-2019, 2019
Zehu Yuan, Wanhong Li, Fadi Li, and Xiangpeng Yue
Arch. Anim. Breed., 62, 501–508, https://doi.org/10.5194/aab-62-501-2019, https://doi.org/10.5194/aab-62-501-2019, 2019
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Sheep milk production and ingredients are influenced by genetic and environmental factors. In this study, we implemented selection signature analysis to identify candidate genes related to ovine milk traits. The results revealed six selection signature regions showing signs of being selected (P < 0.001) located in chromosomes 1, 2, 3, 6, 13 and 18. In addition, 38 QTLs related to sheep milk performance were identified in selection signature regions, which contain 334 candidate genes.
Adel H. M. Ibrahim, Nikolaos Tzanidakis, Smaragda Sotiraki, Huitong Zhou, and Jonathan G. H. Hickford
Arch. Anim. Breed., 62, 413–422, https://doi.org/10.5194/aab-62-413-2019, https://doi.org/10.5194/aab-62-413-2019, 2019
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Selective breeding for milk production traits in sheep using molecular marker technology offers a possibility of selecting accurately elite ewes and rams for milk production traits at early age. Our findings suggest that ovine FABP4 has a role in the variation of the milk production traits which may be of economic importance to sheep farmers. Variation in this gene could potentially be used as gene markers for milk production traits if such associations exist.
Isabel Álvarez, Iván Fernández, Albert Soudré, Amadou Traoré, Lucía Pérez-Pardal, Moumouni Sanou, Stephane A. R. Tapsoba, Nuria A. Menéndez-Arias, and Félix Goyache
Arch. Anim. Breed., 62, 313–323, https://doi.org/10.5194/aab-62-313-2019, https://doi.org/10.5194/aab-62-313-2019, 2019
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Increasing genetic resistance to gastrointestinal parasite infections in sheep would limit the use of drugs and the emergence of resistant parasites. However, this is a very complex trait. The identification of genomic areas associated with the trait is hindered by genotype–environment interactions. Therefore, it is necessary to obtain information from non-cosmopolitan sheep populations. Here, the West African Djallonké sheep genomic profile is analyzed to contribute to solve this gap.
Hamid-Reza Amini, Amir Ajaki, Majid Farahi, Mitra Heidari, Ahmad Pirali, Mohsen Forouzanfar, and Shahin Eghbalsaied
Arch. Anim. Breed., 61, 153–160, https://doi.org/10.5194/aab-61-153-2018, https://doi.org/10.5194/aab-61-153-2018, 2018
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Birth of twins is partly controlled by genetic factors. Here, we genotyped ewes with triplet births, twin births, and single births as well as two infertile ewes from Iranian sheep breeds for the BMP15 gene. A new mutation was detected in two sterile ewes and all ewes with triplet-birth lambing. There is a relationship between the mutation and higher litter numbers. However, this mutation is not responsible for sterility or triplet births in Iranian sheep.
Katarzyna Ropka-Molik, Jan Knapik, Marek Pieszka, Tomasz Szmatoła, and Katarzyna Piórkowska
Arch. Anim. Breed., 60, 243–250, https://doi.org/10.5194/aab-60-243-2017, https://doi.org/10.5194/aab-60-243-2017, 2017
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The aim of present study was the analysis of differences in expression profiles of ovine genes related to lipid metabolism (LPL, ACACA, SCD) depending on feeding system and tissue type (fat, liver). The genes expression measurement showed that supplementation of diet with an addition of fresh grass or red clover modified the expression of all genes in fat tissue. The nutrigenomic regulation of analyzed genes confirmed that these genes play a critical role in regulation of lipid metabolism.
Mohammad Taghi Vajed Ebrahimi, Mohammadreza Mohammadabadi, and Ali Esmailizadeh
Arch. Anim. Breed., 60, 183–189, https://doi.org/10.5194/aab-60-183-2017, https://doi.org/10.5194/aab-60-183-2017, 2017
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Sheep farming in Iran can be a great source of income for marginal and landless farmers. Animal genetic diversity is required to facilitate rapid adaptation to changing breeding objectives. Hence, the objective of this research was to measure the genetic polymorphism of five microsatellite markers in 14 sheep types in Iran. The high degree of variability demonstrated within these sheep implies that these populations are rich reservoirs of genetic diversity that must be preserved.
Ewa Grochowska, Bronisław Borys, Piotr Janiszewski, Jan Knapik, and Sławomir Mroczkowski
Arch. Anim. Breed., 60, 161–173, https://doi.org/10.5194/aab-60-161-2017, https://doi.org/10.5194/aab-60-161-2017, 2017
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The aim of this study was to investigate the polymorphism in the IGF-I gene and its associations with growth, body size, carcass and meat quality traits in Coloured Polish Merino sheep. The IGF-I genotype was found to have an effect on fore shank weight, kidney fat class and EUROP fat class, external fatness on carcass class, drip loss, and subjective assessment of meat colour. The IGF-I gene could be considered as a candidate gene of selected carcass and meat quality traits in sheep.
Haidong Zhao, Shuai He, Yanjiao Zhu, Xin Cao, Renyun Luo, Yong Cai, Hongwei Xu, and Xiuzhu Sun
Arch. Anim. Breed., 60, 79–85, https://doi.org/10.5194/aab-60-79-2017, https://doi.org/10.5194/aab-60-79-2017, 2017
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The 29 bp indel of sheep LHX3 gene was firstly verified in four Chinese indigenous sheep breeds of various fecundity. Genotypic frequency and allelic frequency distributions were significantly different between the high-fecundity breeds (Hu sheep, HS; small-tail Han sheep, STHS; and Lanzhou fat-tail sheep, LFTS) and the low-fecundity breed (Tong sheep (TS)) based on an χ2 test (P < 0.05). Moreover, four significant differences were found in body length and chest width in TS and STHS (P < 0.05).
Parisa Nadri, Saeid Ansari-Mahyari, and Azadeh Zahmatkesh
Arch. Anim. Breed., 59, 167–172, https://doi.org/10.5194/aab-59-167-2016, https://doi.org/10.5194/aab-59-167-2016, 2016
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In this research, the effect of purmorphamine on mRNA expression of the SHH signaling downstream molecules Ptch1, Gli1, Smo, Hdac1, Hdac2 and Hdac3 in ovine two-cell embryos was studied. Regarding the presence of SHH signaling molecules in two-cell embryos and their response to purmorphamine, it can be suggested that SHH signaling is probably active before embryonic genome activation in ovine embryos.
K. Ropka-Molik, J. Knapik, M. Pieszka, and T. Szmatoła
Arch. Anim. Breed., 59, 37–43, https://doi.org/10.5194/aab-59-37-2016, https://doi.org/10.5194/aab-59-37-2016, 2016
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Stearoyl-CoA desaturase 1 is a critical enzyme that catalyzes the synthesis of monounsaturated fatty acids. The objective of the present study was to evaluate the level of mRNA of SCD1 gene in three different ovine tissues strongly associated with lipid homeostasis. The significant correlation between SCD1 transcript abundance and fattening and slaughtering traits (fatness traits) indicates the ability to improve important production traits in sheep via modification of expression of SCD1 gene.
Cited articles
Almahdy, H., Tess, M. W., El-Tawil, E., Shehata, E., and Mansour, H.:
Evaluation of Egyptian sheep production systems: I. Breed crosses and
management systems, J. Anim. Sci., 78, 283–287,
https://doi.org/10.2527/2000.782283x, 2000.
Asif, A. R., Qadri, S., Ijaz, N., Javed, R., Ansari, A. R., Awais, M.,
Younus, M., Riaz, H., and Du, X.: Genetic signature of strong recent
positive selection at interleukin-32 gene in goat, Asian-Aust. J. Anim. Sci,
30, 912–919, 2017.
Byun, S., Fang, Q., Zhou, H., and Hickford, J.: An effective method for
silver-staining DNA in large numbers of polyacrylamide gels, Anal.
Biochem., 385, 174–175, 2009.
Dominik, S., Duff, C. J., Byrne, A. I., Daetwyler, H., and Reverter, A.:
Ultra-small SNP panels to uniquely identify individuals in thousands of
samples, Anim. Prod. Sci., 61, 1796–1800, 2021.
Dry, F.: Hairy fibres of the Romney sheep. Collected reprints, New Zeal.
J. Agr., 46, 1–48, 1935.
El-Gabbas, H.: A survey study for the appraisals of some wool traits in
Barki sheep along the north-western desert of Egypt, Annals of Agriculture
Science, 39, 269–278, 1994.
El-Gabbas, H.: Wool properities of the Egyptian breeds of sheep as blend
consignments for the carpet manufacture, Egyptian Journal of Animal
Production, 36, 9–23, 1999.
El-Gabba, H. and El-Wakil, S.: Selection index for wool improvement in Barki
sheep, Journal of Animal and Poultry Production, 7, 33–38, 2016.
Elshazly, A. G. and Youngs, C. R.: Sheep, cattle and buffalo populations (in millions of head) in Egypt, Egyptian Journal of Sheep & Goat
Sciences, 14, 39–52, 2019.
Farag, I. M., Darwish, H. R., Darwish, A. M., El-Shorbagy, H. M., and Ahmed,
R. W.: Effect of genetic polymorphisms of the KAP1.1 and KAP1.3 genes on
wool characteristics in Egyptian sheep, J. Biol. Sci., 18,
158–164, https://doi.org/10.3923/jbs.2018.158.164, 2018.
Galal, S., Abdel-Rasoul, F., Shaat, I., and Anous, M.: On-station
characterization of small ruminant breeds in Egypt. Characterization of
Small Ruminant Breeds in West Asia and North Africa, edited by: Inigez, L.,
Aleppo, ICARDA, 141–193, 2005.
Gong, H., Zhou, H., Forrest, R. H. J., Li, S., Wang, J., Dyer, J. M., Luo,
Y., and Hickford, J. G. H.: Wool keratin-associated protein genes in sheep
– a review, Genes (Basel), 7, 24, https://doi.org/10.3390/genes7060024, 2016.
Helal, A., Agamy, R., Al-Betar, E. M., Mahouda, S. F., and Abdel-mageed, I.
I.: Effect of a Subjective Grading System and Blending with Polyester on
Selected Wool and Yarn Characteristics of Subtropical Egyptian Barki Sheep, Fibres Text. East. Eur.,
5, 23–27, https://doi.org/10.5604/01.3001.0013.2897, 2019.
Kinsella, R. J., Kähäri, A., Haider, S., Zamora, J., Proctor, G.,
Spudich, G., Almeida-King, J., Staines, D., Derwent, P., Kerhornou, A.,
Kersey, P., and Flicek, P.: Ensembl BioMarts: A hub for data retrieval
across taxonomic space, Database, 2011, 1–9,
https://doi.org/10.1093/database/bar030, 2011.
Kwon, J. and Goate, A.: The candidate gene approach, Alcohol Res. Health, 24,
164–168, 2000.
Li, S., Zhou, H., Gong, H., Zhao, F., Wang, J., Liu, X., Luo, Y., and
Hickford, J. G. H.: Identification of the ovine Keratin-Associated protein
22-1 (KAP22-1) gene and its effect on wool traits, Genes (Basel), 8, 10–16,
https://doi.org/10.3390/genes8010027, 2017.
Li, S., Xi, Q., Zhao, F., Wang, J., He, Z., Hu, J., Liu, X., and Luo, Y.: A
highly polymorphic caprine keratin-associated protein gene identified and
its effect on cashmere traits, J. Anim. Sci., 99, skab233,
https://doi.org/10.1093/jas/skab233, 2021.
Mortimer, S. I., Robinson, D. L., Atkins, K. D., Brien, F. D., Swan, A. A.,
Taylor, P. J., and Fogarty, N. M.: Genetic parameters for visually assessed
traits and their relationships to wool production and liveweight in
Australian Merino sheep, Anim. Prod. Sci., 49, 32–42, 2009.
Noelle, C. and Chunhua, W.: The Sheep Genome, in: Molecular and Quantitative
Animal Genetics, edited by: Khatib, H., Wiley Blackwell, 131–142, ISBN 978-1-118-67740-7, 2015.
Oldenbroek, K. and Van der Waajj, L.: Textbook Animal Breeding and Genetics
for BSc students. Centre for Genetic Resources The Netherlands and Animal
Breeding and Genomics Centre, Groen Kennisnet, Wageningen University,
the Netherlands, https://wiki.groenkennisnet.nl/display/TAB/ (last access: 2 August 2021), 2015.
Parsons, Y., Cooper, D., and Piper, L.: Evidence of linkage between
high-glycine-tyrosine keratin gene loci and wool fibre diameter in a Merino
half-sib family, Anim. Genet., 25, 105–108, 1994.
Patnala, R., Clements, J., and Batra, J.: Candidate gene association
studies: a comprehensive guide to useful in silicotools, BMC Genetics, 14, 39,
https://doi.org/10.1186/1471-2156-14-39, 2013.
Powell, B. and Rogers, G.: The role of keratin proteins and their genes in
the growth, structure and properties of hair, in: Formation and Structure
of Human Hair, edited by: Jolle's, P., Zahn, H., and Höcker, H., Birkhäuser Verlag, Basel, 59–148, 1997.
Sallam, A. M.: Risk factors and genetic analysis of pre-weaning mortality in
Barki lambs, Livest. Sci., 230, 103818,
https://doi.org/10.1016/j.livsci.2019.103818, 2019.
Sallam, A. M., Zare, Y., Shook, G., Collins, M., and Kirkpatrick, B. W.: A
positional candidate gene association analysis of susceptibility to
paratuberculosis on bovine chromosome 7, Infection, Genetics and Evolution,
65, 163–169, 2018.
Sallam, A. M., Gad-Allah, A. A., and Al-Bitar, E. M.: Association analysis
of the ovine KAP6-1 gene and wool traits in Barki sheep, Anim.
Biotechnol., 32, 733–739, https://doi.org/10.1080/10495398.2020.1749064,
2021.
SAS: SAS Institute Inc., Cary, NC, USA, https://www.sas.com/en_us/home.html (last access: 2 August 2021), 2004.
Tao, J., Huitong, Z., Hua, G. Z., Yang, Qing, M., Long, C., Wei, D.,
Yingkang, L., and Hickford, G.: Short communication: Variation in the KAP6-1
gene in Chinese Tan sheep and associations with variation in wool traits,
Small Ruminant Res., 154, 129–132, https://doi.org/10.1016/j.smallrumres.2017.08.001,
2017.
Thomas, D.: Genetic Improvement in Sheep through Selection, in: Molecular
and Quantitative Animal Genetics, edited by: Khatib, H., 73–88, Wiley Blackwell, ISBN 978-1-118-67740-7, 2015.
Ullah, F., Jamal, S. M., Ekegbu, U. J., Haruna, I. L., Zhou, H., and
Hickford, J. G. H.: Polymorphism in the ovine keratin-associated protein
gene KRTAP7-1 and its association with wool characteristics, J.
Anim. Sci., 98, skz381, https://doi.org/10.1093/jas/skz381, 2020a.
Ullah, F., Jamal, S., Zhou, H., and Hickford, J.: Variation in the KRTAP6-3
gene and its association with wool characteristics in Pakistani sheep breeds
and breed-crosses, Trop. Anim. Health Pro., 52, 3035–3043,
https://doi.org/10.1007/s11250-020-02322-6, 2020b.
Ullah, F., Jamal, S. M., Zhou, H., and Hickford, J. G. H.: Variation in
ovine KRTAP8-1 affects mean staple length and opacity of wool fiber, Anim.
Biotechnol., https://doi.org/10.1080/10495398.2021.1990078, online first, 2021.
Wilkening, S., Chen, B., Bermejo, J., and Canzian, F.: Is there still a need
for candidate gene approaches in the era of genome-wide association
studies?, Genomics, 93, 415–419, 2009.
Williams, J., Kubelic, A., Livak, K., Rafalski, J., and Tingey, S.: DNA
polymorphism amplified by arbitrary, Nucl. Acid. Res, 18, 6534–6535, 1990.
Zhu, M. and Zhao, S.: Candidate gene identification approach: progress and
challenges, Int. J. Biol. Sci., 3, 420–427, https://doi.org/10.7150/ijbs.3.420,
2007.
Short summary
This report provides valuable information about an interesting candidate gene underlying new genetic markers, which may be used for marker-assisted selection to improve quantity and quality of wool produced from Egyptian sheep. A part of the KAP22-1 gene was amplified, sequenced and genotyped in an Egyptian sheep population with important wool traits available for the animals for further association analysis.
This report provides valuable information about an interesting candidate gene underlying new...
