Articles | Volume 64, issue 2
https://doi.org/10.5194/aab-64-335-2021
https://doi.org/10.5194/aab-64-335-2021
Original study
 | 
18 Aug 2021
Original study |  | 18 Aug 2021

Trehalose can effectively protect sheep epididymis epithelial cells from oxidative stress

Zhaojin Luan, Xiaomei Fan, Yongchao Zhao, Huizi Song, Wei Du, Jiaoxia Xu, Zhaochen Wang, Wenguang Zhang, and Jiaxin Zhang

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Cited articles

Ateşşahin, A., Bucak, M. N., Tuncer, P. B., and Kızıl, M.: Effects of anti-oxidant additives on microscopic and oxidative parameters of Angora goat semen following the freeze–thawing process, Small Ruminant Res., 77, 38–44, 2008. 
Bieganski, R. M., Fowler, A., Morgan, J. R., and Toner, M.: Stabilization of active recombinant retroviruses in an amorphous dry state with trehalose, Biotechnol Prog., 14, 615–620, 1998. 
Brigelius-Flohé, R. and Maiorino, M.: Glutathione peroxidases, Biochim. Biophys. Acta, 1830, 3289–3303, 2013. 
Büyükleblebici, S., Tuncer, P. B., Bucak, M. N., Eken, A., Sarıözkan, S., Taşdemir, U., and Endirlik, B. U.: Cryopreservation of bull sperm: Effects of extender supplemented with different cryoprotectants and antioxidants on sperm motility, antioxidant capacity and fertility results, Anim. Reprod. Sci., 150, 77–83, 2014. 
Bucak, M. N., Ateşşahin, A., Varişli, O., Yüce, A., Tekin, N., and Akçay, A.: The influence of trehalose, taurine, cysteamine and hyaluronan on ram semen: Microscopic and oxidative stress parameters after freeze–thawing process, Theriogenology, 67, 1060–1067, 2007. 
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Short summary
In this work, we analyzed the effects of trehalose on sheep EEC proliferation and possible mechanisms affecting its role. Our study suggested that exogenous trehalose exhibits antioxidant activity through increasing the activities of CAT, GSH-Px, and the expression level of GPX5. The cell line cultured provides a strong resource for elucidating the transcriptional networks that coordinate functions of sheep epididymis epithelium and have greatly enhanced our understanding of epididymis biology.