Articles | Volume 62, issue 1
Arch. Anim. Breed., 62, 189–197, 2019
https://doi.org/10.5194/aab-62-189-2019
Arch. Anim. Breed., 62, 189–197, 2019
https://doi.org/10.5194/aab-62-189-2019

Original study 16 Apr 2019

Original study | 16 Apr 2019

Genetic variations in the sheep SIRT7 gene and their correlation with body size traits

Hongwei Xu et al.

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Cited articles

Blank, M. F. and Grummt, I.: The seven faces of SIRT7, Transcription, 8, 67–74, https://doi.org/10.1080/21541264.2016.1276658, 2017. 
Bosch-Presegué, L. and Vaquero, A.: Sirtuins in stress response: guardians of the genome, Oncogene, 33, 3764–3775, https://doi.org/10.1038/onc.2013.344, 2014. 
Cui, Y., Yan, H. L., Wang, K., Xu, H., Zhang, X. L., Zhu, H. J., Liu, J. W., Qu, L., Lan, X. Y., and Pan, C. Y.: Insertion/Deletion within the KDM6A gene is significantly associated with litter size in goat, Front. Genet., 9, 91, https://doi.org/10.3389/fgene.2018.00091, 2018. 
de Aguiar Vallim, T. Q., Tarling, E. J., Ahn, H., Hagey, L. R., Romanoski, C. E., Lee, R. G., Graham, M. J., Motohashi, H., Yamamoto, M., and Edwards, P. A.: MAFG is a transcriptional repressor of bile acid synthesis and metabolism, Cell Metab., 21, 298–311, https://doi.org/10.1016/j.cmet.2015.01.007, 2015. 
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Short summary
In this study, two novel indels within the sheep SIRT7 gene, 5′ promoter region-insertion-7 bp and 3′ UTR-insertion-17 bp, were identified in 709 individuals from five different Chinese and Mongolian sheep breeds. Genetic diversity within the SIRT7 gene and its effect on body size traits were explored. The findings from this research will potentially provide useful DNA markers for the improvement of economic traits in sheep genetic breeding.