Articles | Volume 62, issue 1
Arch. Anim. Breed., 62, 171–179, 2019
https://doi.org/10.5194/aab-62-171-2019
Arch. Anim. Breed., 62, 171–179, 2019
https://doi.org/10.5194/aab-62-171-2019

Original study 11 Apr 2019

Original study | 11 Apr 2019

Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits

Yi-Lei Ma et al.

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Cited articles

Adams, T. E., Epa, V. C., Garrett, T. P. J., and Ward, C. W.: Structure and function of the type 1 insulin-like growth factor receptor, Cell. Mol. Life Sci., 57, 1050, https://doi.org/10.1007/PL00000744, 2000. 
Bae, J. S., Cheong, H. S., Kim, L. H., Namgung, S., Park, T. J., Chun, J. Y., Kim, J. Y., Pasaje, C. F., Lee, J. S., and Shin, H. D.: Identification of copy number variations and common deletion polymorphisms in cattle, Bmc Genomics, 11, 232, https://doi.org/10.1186/1471-2164-11-232, 2010. 
Baserga, R., Peruzzi, F., and Reiss, K.: The IGF-1 receptor in cancer biology, Int. J. Cancer, 107, 873–877, 2003. 
Beckmann, J. S., Estivill, X., and Antonarakis, S. E.: Copy number variants and genetic traits: closer to the resolution of phenotypic to genotypic variability, Nat. Rev. Genet. 8, 639–646, 2007. 
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Short summary
We used lots of Chinese cattle to detect the specific regional variation in the IGF1R genome. It was found that this variation in the Chinese cattle population is related to the weight and height of the cattle. There is a lot of genetic information in this mutated region, which may be the cause affecting the traits. Our study provided a preliminary result for the functional role of the IGF1R variation in larger populations and for an important marker in cattle breeding programs.