Articles | Volume 68, issue 1
https://doi.org/10.5194/aab-68-171-2025
https://doi.org/10.5194/aab-68-171-2025
Original study
 | 
03 Mar 2025
Original study |  | 03 Mar 2025

Identification of a novel InDel locus within the ACSL5 gene and its association with body measurement traits in goats

Ao Wang, Xianfeng Wu, Qian Xu, Benzhi Wang, Tianfang Xiao, Yuan Liu, and Wenyang Li

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Cited articles

Bai, Y., Yuan, R., Luo, Y., Kang, Z., Zhu, H., Qu, L., Lan, X., and Song, X.: Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (AKAP12) Gene and Their Effects on Growth Traits, Animals, 11, 2090, https://doi.org/10.3390/ani11072090, 2021. 
Bi, Y., He, L., Feng, B., Lan, X., Song, X., Qu, L., and Pan, C.: A 5-bp mutation within MSTN/GDF8 gene was significantly associated with growth traits in Inner Mongolia White Cashmere goats, Anim. Biotechnol., 32, 610–615, https://doi.org/10.1080/10495398.2020.1736088, 2021. 
Bi, Y., Chen, Y., Xin, D., Liu, T., He, L., Kang, Y., Pan, C., Shen, W., Lan, X., and Liu, M.: Effect of indel variants within the sorting nexin 29 (SNX29) gene on growth traits of goats, Anim. Biotechnol., 33, 914–919, https://doi.org/10.1080/10495398.2020.1846547, 2022. 
Bowman, T. A., O'Keeffe, K. R., D'Aquila, T., Yan, Q. W., Griffin, J. D., Killion, E. A., Salter, D. M., Mashek, D. G., Buhman, K. K., and Greenberg, A. S.: Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption, Mol. Metab., 5, 210–220, https://doi.org/10.1016/j.molmet.2016.01.001, 2016. 
Bu, S. Y. and Mashek, D. G.: Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways, J. Lipid. Res., 51, 3270-3280, https://doi.org/10.1194/jlr.M009407, 2010. 
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Short summary
This study investigated the spatiotemporal expression pattern of ACSL5 (acyl-CoA synthetase 5) in goats and the association between its polymorphism and body measurement traits. We found that the ACSL5 gene was  expressed ubiquitously in the nine tested tissues of Fuqing goats. The del41712 locus of the ACSL5 gene has a significant impact on multiple body measurement traits of goats, providing a basis for the application of marker-assisted selection in goat breeding.
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