Articles | Volume 68, issue 1
https://doi.org/10.5194/aab-68-171-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-68-171-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Identification of a novel InDel locus within the ACSL5 gene and its association with body measurement traits in goats
Ao Wang
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
current address: Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China
Xianfeng Wu
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China
current address: Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China
Qian Xu
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China
Benzhi Wang
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Tianfang Xiao
College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Yuan Liu
CORRESPONDING AUTHOR
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China
Wenyang Li
CORRESPONDING AUTHOR
Fujian Provincial Key Laboratory of Animal Genetics and Breeding/Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China
Related authors
No articles found.
Haiyu Zhao, Sihuan Zhang, Xianfeng Wu, Chuanying Pan, Xiangchen Li, Chuzhao Lei, Hong Chen, and Xianyong Lan
Arch. Anim. Breed., 62, 59–68, https://doi.org/10.5194/aab-62-59-2019, https://doi.org/10.5194/aab-62-59-2019, 2019
Short summary
Short summary
This study analyzed the DNA methylation profile of the PITX1 gene and its relevance to lactation performance in goats. The methylation rates of the overall CpG island and the 3rd and 12th CpG-dinucleotide loci in blood were significantly associated with average milk yield. The overall methylation rates of the CpG island in mammary gland tissue from dry and lactation periods showed a significant difference. These results could be used as potential epigenetic markers for lactation performance.
Xian-Feng Wu, Yuan Liu, Cheng-Fang Gao, Xin-Zhu Chen, Xiao-Pei Zhang, and Wen-Yang Li
Arch. Anim. Breed., 61, 59–70, https://doi.org/10.5194/aab-61-59-2018, https://doi.org/10.5194/aab-61-59-2018, 2018
Short summary
Short summary
ACOX1 is vital for fatty acid oxidation and deposition. The alternative splicing events of ACOX1 have not been reported in goats. Here, we found a novel splice variant (ACOX1-SV1) and a complete isoform (ACOX1). ACOX1 and ACOX1-SV1 were expressed at high levels in the liver, spleen, brain and fat in kid and adult goats. In both groups, the mRNA level of ACOX1 was high in fat and that of ACOX1-SV1 was high in liver. These findings should provide new insights on the function of ACOX1.
Related subject area
Functional genetics
Correlation and regression analysis of the KRT27 and ELOVL4 genes in cashmere fineness and other production performances in Liaoning cashmere goats
Genome-wide association study of the antibody response to Corynebacterium pseudotuberculosis in sheep
The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing AP1S2
Exploring the association between SLC11A1 and CARD15 gene polymorphisms and tuberculosis susceptibility in Holstein cattle
Genetic analysis of platelet-derived growth factor receptor-like gene (PDGFRL) polymorphism and melanin traits in Lanping black-boned sheep (Ovis aries)
Investigating InDels in YAP and TAZ genes and their impact on growth characteristics in goats
The genetic diversity and structure of the Haflinger horse population in the Czech Republic
Evaluation of genetic diversity within different rabbit (Oryctolagus cuniculus) genotypes utilizing start codon targeted (SCoT) and inter-simple sequence repeat (ISSR) molecular markers
Analysis of genetic variants for different horn phenotypes and their inheritance in Icelandic sheep
Molecular characterization, function, tissue differential expression, and single-nucleotide polymorphism of buffalo TP53 gene
Myostatin mutation (g+6723G > A) introgression: comparative analysis of growth, slaughter, and carcass traits in Texel, Pırlak, and their crosses (F1 and BC1)
Polymorphisms of the BMPR1B, BMP15 and GDF9 fecundity genes in four Chinese sheep breeds
Polymorphism and expression of GLUD1 in relation to reproductive performance in Jining Grey goats
Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats
CircGUCY2C regulates cofilin 1 by sponging miR-425-3p to promote the proliferation of porcine skeletal muscle satellite cells
Novel MHC BLB2 gene polymorphism and its association with IgY concentration and Newcastle disease antibody titer in IPB-D2 chickens
Hua Ma, Weihang Hong, Lingjun Nie, Shuaitong Li, Qingyu Yuan, Ran Duan, Qiying Zhan, Lingchao Kong, and Zeying Wang
Arch. Anim. Breed., 68, 135–149, https://doi.org/10.5194/aab-68-135-2025, https://doi.org/10.5194/aab-68-135-2025, 2025
Short summary
Short summary
This study investigated single-nucleotide polymorphism (SNP) in the keratin 27 (KRT27, 1919G/A) and elongation of very-long-chain fatty acids 4 (ELOVL4, 28666C/T) genes, which are associated with production traits in Liaoning cashmere goats. Multivariate analysis was also conducted. The GGCC genotype combination was associated with finer cashmere quality. The GGTT haplotype exhibited a multigenic effect. The TT genotype demonstrated pleiotropy.
Jitka Kyselová, Ladislav Tichý, Jiřina Marková, Artur Gurgul, Zuzana Sztankóová, Karel Vališ, Soňa Šlosárková, Kateřina Kavanová, Monika Beinhauerová, and Tomasz Szmatola
Arch. Anim. Breed., 68, 109–124, https://doi.org/10.5194/aab-68-109-2025, https://doi.org/10.5194/aab-68-109-2025, 2025
Short summary
Short summary
This study explored how genetics might influence the ability of sheep to fight a severe infection known as caseous lymphadenitis (CLA). By examining the genome of 321 Suffolk sheep, we identified specific genetic markers indicating biological processes and pathways that might be associated with the resistance of some sheep to this disease. This discovery is a step towards breeding sheep that are naturally more capable of fighting off CLA, potentially leading to healthier flocks.
Baoyu Zhang, Runlai Liu, Tao Ma, Xinyu Li, Yuxin Zhao, Huixian Su, Jianping Li, Yumei Li, Huaizhi Jiang, and Qiaoling Zhang
Arch. Anim. Breed., 68, 125–134, https://doi.org/10.5194/aab-68-125-2025, https://doi.org/10.5194/aab-68-125-2025, 2025
Short summary
Short summary
Coat color is an important economic trait of Cashmere goats. miRNA-211 is differentially expressed in the skin of Cashmere goats with different coat colors, but the mechanism is unclear. After the targeting relationship between miRNA-211 and AP1S2 was clarified in vitro and in vivo, antagomiRNA-211 was injected into BALB/c, and the expression of miRNA-211 and AP1S2 and melanin content was analyzed. It was demonstrated that miRNA-211 impacts melanogenesis by downregulating AP1S2.
Safa Bejaoui, Nour Elhouda Fehri, Mohamed Amine Ferchichi, and Bayrem Jemmali
Arch. Anim. Breed., 67, 515–521, https://doi.org/10.5194/aab-67-515-2024, https://doi.org/10.5194/aab-67-515-2024, 2024
Short summary
Short summary
Genetic variation in the SLC11A1 (C>G) and CARD15 (A/G) genes may contribute to the onset and development of bovine tuberculosis (bTB), supporting the hypothesis that polymorphisms in these genes are associated with the risk of bTB in Holstein cattle. bTB is a complicated disease that is probably influenced by polymorphisms in many genes, particularly those related to the immune system and host–pathogen interactions.
Dan Yue, Chaochao Peng, Sameeullah Memon, Azeem Iqbal, Heli Xiong, Xiaoming He, Ying Lu, and Weidong Deng
Arch. Anim. Breed., 67, 383–392, https://doi.org/10.5194/aab-67-383-2024, https://doi.org/10.5194/aab-67-383-2024, 2024
Short summary
Short summary
We focus on the Lanping black-boned sheep (LPBB) because it is the only mammal that resembles the Chinese silky fowl in the world. LPBB is characterized by black pigmentation in its plasma colorimetry and had its internal organs compared to the reddish color in Lanping normal sheep. Although the literature is abundant in genetic case studies, the processes of pigmentation remain obscure. We thus investigate the association between the PDGFRL gene polymorphism of LPBB and melanin deposition.
Wanxia Zhao, Ziteng Wang, Yichen Lei, Xiaoqin Tang, Xiaohua Yi, Junyi Jiang, Jiapeng Li, Shuhui Wang, and Xiuzhu Sun
Arch. Anim. Breed., 67, 343–351, https://doi.org/10.5194/aab-67-343-2024, https://doi.org/10.5194/aab-67-343-2024, 2024
Short summary
Short summary
In this study, InDels loci of YAP and TAZ genes in two goat breeds were screened and identified, and the association between InDels loci of YAP and TAZ genes and growth traits was analyzed. The results showed that eight InDels loci were identified from goat YAP and TAZ genes. These InDels loci significantly affected growth traits such as chest width, body height, and body weight of goats. These findings can provide new molecular markers for goat molecular breeding.
Michaela Kulišťáková, Iva Jiskrová, Irena Vrtková, Petra Bartoňová, and Tomáš Urban
Arch. Anim. Breed., 67, 323–333, https://doi.org/10.5194/aab-67-323-2024, https://doi.org/10.5194/aab-67-323-2024, 2024
Short summary
Short summary
The aim of this study is to assess the genetic diversity and structure of the Haflinger horse population in the Czech Republic based on 16 microsatellite loci. The results indicated a high level of diversity and the presence of greater admixture, and the identification of distinct genetic clusters suggested a significant gene flow. These findings imply that the population exhibits sufficient genetic variability and diversity.
Nouran Elsayed, Abd Elrahman E. Mandour, Mamdouh K. A. Amin, Fayiz M. Reda, Heba S. A. Taha, Alessandro Di Cerbo, Mahmoud M. Azzam, and Mahmoud Alagawany
Arch. Anim. Breed., 67, 285–295, https://doi.org/10.5194/aab-67-285-2024, https://doi.org/10.5194/aab-67-285-2024, 2024
Short summary
Short summary
It was suggested that the start codon targeted (SCoT) markers may be more effective than inter-simple sequence repeat (ISSR) for differentiating and identifying the genetic variations within investigated breeds. Also, the usage of molecular markers of SCoT and ISSR may be more proper for calculating genetic diversity and common ancestry among tested rabbit breeds.
Rebecca Simon, Karólína Elísabetardóttir, and Gesine Lühken
Arch. Anim. Breed., 67, 237–246, https://doi.org/10.5194/aab-67-237-2024, https://doi.org/10.5194/aab-67-237-2024, 2024
Short summary
Short summary
Genetics of horn traits in sheep are still under investigation. Icelandic sheep were chosen to further characterize this complex trait using known variants as it is highly variable for horn characteristics. Only the published variant for multi-hornedness was in perfect segregation. The absence of horns was analyzed in multi-horned sheep. Only tendencies of association were found for hornlessness and for different horn shapes and sizes, confirming previous results in other breeds.
Lige Huang, Dan Sheng, Xinyang Fan, Ruixia Gao, and Yongwang Miao
Arch. Anim. Breed., 67, 217–230, https://doi.org/10.5194/aab-67-217-2024, https://doi.org/10.5194/aab-67-217-2024, 2024
Short summary
Short summary
The aim of this study was to investigate the role of TP53 in buffalo lactation. The data showed that buffalo TP53 inhibited the expression of genes related to milk protein and milk fat in buffalo mammary epithelial cells by inhibiting the PI3K–AKT–mTOR pathway. These results suggest that TP53 negatively regulates the synthesis of milk protein and milk fat in buffalo through the PI3K–AKT–mTOR pathway. This study provides new insights into the functional role of TP53 in buffalo lactation.
Serdar Koçak, Mustafa Tekerli, Metin Erdoğan, Koray Çelikeloğlu, Ebubekir Yazıcı, Zehra Bozkurt, Özlem Hacan, Mustafa Demirtaş, and Samet Çinkaya
Arch. Anim. Breed., 67, 207–216, https://doi.org/10.5194/aab-67-207-2024, https://doi.org/10.5194/aab-67-207-2024, 2024
Short summary
Short summary
It was detected that Texel and myostatin-carrying BC1 lambs were significantly higher than Pırlak and non-carrying BC1 lambs in the MLD area at weaning. Myostatin-carrying BC1 lambs had a superiority to Pırlak lambs in terms of muscle conformation and fatness of the hind leg. Myostatin-carrying BC1 lambs were found to be better than Pırlak in growth performance. It was concluded that the Pırlak lambs may be improved by introgression of myostatin mutation.
Jinxin Wang, Yufang Liu, Siwu Guo, Ran Di, Xiangyu Wang, Xiaoyun He, and Mingxing Chu
Arch. Anim. Breed., 67, 51–60, https://doi.org/10.5194/aab-67-51-2024, https://doi.org/10.5194/aab-67-51-2024, 2024
Short summary
Short summary
Finding polymorphisms of genes can provide potential molecular genetic markers for sheep reproduction. This study investigated the polymorphisms of three major reproductive genes (BMPR1B, BMP15 and GDF9) in Chinese sheep and found that BMPR1B and GDF9 might be the major genes influencing the reproductive performance of Chinese sheep breeds. This result might contribute to improving the prolificacy traits of native Chinese sheep in the future.
Wei Wang, Yongjuan Wang, Yufang Liu, Guiling Cao, Ran Di, Jinyu Wang, and Mingxing Chu
Arch. Anim. Breed., 66, 411–419, https://doi.org/10.5194/aab-66-411-2023, https://doi.org/10.5194/aab-66-411-2023, 2023
Short summary
Short summary
In this study, GLUD1 single nucleotide polymorphisms (SNPs) were analyzed in early-puberty goats and delayed-puberty goat breeds by sequencing and restriction fragment length polymorphism (RFLP). The present study aimed to find genetic markers related to sexual precocity and high fertility in goats and to provide a scientific basis for marker-assisted early selection of reproductive performance.
Zühal Gündüz and Osman Biçer
Arch. Anim. Breed., 66, 369–378, https://doi.org/10.5194/aab-66-369-2023, https://doi.org/10.5194/aab-66-369-2023, 2023
Short summary
Short summary
The Kilis goat has emerged as a breed with a unique genetic profile that reflects its complex ancestry due to historical crossbreeding between the Damascus and Hair goat populations in Türkiye. The Kilis goat is well adapted to arid areas and is known for its high milk yield. Therefore, it holds great potential for milk production and genetic improvement programs in Türkiye. For this reason, some genes that affect milk yield were investigated.
Kunlong Qi, Yaqing Dou, Chenlei Li, Yingke Liu, Chenglei Song, Xinjian Li, Kejun Wang, Ruimin Qiao, Xiuling Li, Feng Yang, and Xuelei Han
Arch. Anim. Breed., 66, 285–298, https://doi.org/10.5194/aab-66-285-2023, https://doi.org/10.5194/aab-66-285-2023, 2023
Short summary
Short summary
With the rapid development of sequencing technology, it has been found that circRNAs play an important role in skeletal muscle development. During the growth and development of livestock, the growth and development of muscle fibers are closely related to the number, proliferation, and differentiation capacity of skeletal muscle satellite cells, thereby affecting meat quality. Notably, more and more studies now suggest that changes in circRNA expression may be associated with meat quality.
Dwi Lestari, Sri Murtini, Niken Ulupi, Asep Gunawan, and Cece Sumantri
Arch. Anim. Breed., 66, 275–283, https://doi.org/10.5194/aab-66-275-2023, https://doi.org/10.5194/aab-66-275-2023, 2023
Short summary
Short summary
IPB-D2 chickens are one of the local Indonesian chickens that are being developed today. IPB-D2 chickens have disease-resistant traits. Selection is not only carried out conventionally but is also developed by molecular selection methods. By utilizing gene diversity in the major histocompatibility complex gene group, it was found that there were several single-nucleotide polymorphisms in the B Locus Beta 2 gene significantly associated with immunoglobulin Y concentrations in IPB-D2 chickens.
Cited articles
Bai, Y., Yuan, R., Luo, Y., Kang, Z., Zhu, H., Qu, L., Lan, X., and Song, X.: Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (AKAP12) Gene and Their Effects on Growth Traits, Animals, 11, 2090, https://doi.org/10.3390/ani11072090, 2021.
Bi, Y., He, L., Feng, B., Lan, X., Song, X., Qu, L., and Pan, C.: A 5-bp mutation within MSTN/GDF8 gene was significantly associated with growth traits in Inner Mongolia White Cashmere goats, Anim. Biotechnol., 32, 610–615, https://doi.org/10.1080/10495398.2020.1736088, 2021.
Bi, Y., Chen, Y., Xin, D., Liu, T., He, L., Kang, Y., Pan, C., Shen, W., Lan, X., and Liu, M.: Effect of indel variants within the sorting nexin 29 (SNX29) gene on growth traits of goats, Anim. Biotechnol., 33, 914–919, https://doi.org/10.1080/10495398.2020.1846547, 2022.
Bowman, T. A., O'Keeffe, K. R., D'Aquila, T., Yan, Q. W., Griffin, J. D., Killion, E. A., Salter, D. M., Mashek, D. G., Buhman, K. K., and Greenberg, A. S.: Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption, Mol. Metab., 5, 210–220, https://doi.org/10.1016/j.molmet.2016.01.001, 2016.
Bu, S. Y. and Mashek, D. G.: Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways, J. Lipid. Res., 51, 3270-3280, https://doi.org/10.1194/jlr.M009407, 2010.
Chen, B., Cole, J. W., and Grond-Ginsbach, C.: Departure from Hardy Weinberg Equilibrium and Genotyping Error, Frontiers in Genetics, 8, 167, https://doi.org/10.3389/fgene.2017.00167, 2017.
Gassler, N., Roth, W., Funke, B., Schneider, A., Herzog, F., Tischendorf, J. J., Grund, K., Penzel, R., Bravo, I. G., Mariadason, J., Ehemann, V., Sykora, J., Haas, T. L., Walczak, H., Ganten, T., Zentgraf, H., Erb, P., Alonso, A., Autschbach, F., Schirmacher, P., Knüchel, R., and Kopitz, J.: Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing, Gastroenterology, 133, 587–598, https://doi.org/10.1053/j.gastro.2007.06.005, 2007.
Gilbert, R. P., Bailey, D. R., and Shannon, N. H.: Linear body measurements of cattle before and after 20 years of selection for postweaning gain when fed two different diets, J. Anim. Sci., 71, 1712–1720, https://doi.org/10.2527/1993.7171712x, 1993.
Huang, Y., Liu, L., Zhao, M., Zhang, X., Chen, J., Zhang, Z., Cheng, X., and Ren, C.: Feeding regimens affecting carcass and quality attributes of sheep and goat meat – A comprehensive review, Animal Bioscience, 36, 1314–1326, https://doi.org/10.5713/ab.23.0051, 2023.
Janecka, M. J., Rovenolt, F., and Stephenson, J. F.: How does host social behavior drive parasite non-selective evolution from the within-host to the landscape-scale?, Behav. Ecol. Sociobiol. 75, 150, https://doi.org/10.1007/s00265-021-03089-y, 2021.
Kieffer, D. A., Martin, R. J., and Adams, S. H.: Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys, Adv. Nutr., 7, 1111–1121, https://doi.org/10.3945/an.116.013219, 2016.
Kim, J. Y., Jeong, S., Kim, K. H., Lim, W. J., Lee, H. Y., and Kim, N.: Discovery of Genomic Characteristics and Selection Signatures in Korean Indigenous Goats Through Comparison of 10 Goat Breeds, Frontiers in Genetics, 10, 699, https://doi.org/10.3389/fgene.2019.00699, 2019.
Klinkenberg, E., Onwona-Agyeman, K. A., McCall, P. J., Wilson, M. D., Bates, I., Verhoeff, F. H., Barnish, G., and Donnelly, M. J.: Cohort trial reveals community impact of insecticide-treated nets on malariometric indices in urban Ghana, Trans R Soc Trop Med Hyg, 104, 496–503, https://doi.org/10.1016/j.trstmh.2010.03.004, 2010.
Kornberg, A. and Pricer Jr., W. E.: Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids, J. Biol. Chem., 204, 329–343, 1953.
Kwak, H. B., Woodlief, T. L., Green, T. D., Cox, J. H., Hickner, R. C., Neufer, P. D., and Cortright, R. N.: Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes, Int. J. Environ. Res. Pub. He., 16, 1157, https://doi.org/10.3390/ijerph16071157, 2019.
Li, W., Liu, Y., Gao, C., Lan, X., and Wu, X.: A novel duplicated insertion/deletion (InDel) of the CPT1a gene and its effects on growth traits in goat, Anim. Biotechnol., 32, 343–351, https://doi.org/10.1080/10495398.2019.1698433, 2021.
Liao, R., Xie, X., Lv, Y., Dai, J., Lin, Y., and Zhu, L.: Ages of weaning influence the gut microbiota diversity and function in Chongming white goats, Appl. Microbiol. Biot., 105, 3649–3658, https://doi.org/10.1007/s00253-021-11301-2, 2021.
Liu, G., Zhao, Q., Lu, J., Sun, F., Han, X., Zhao, J., Feng, H., Wang, K., and Liu, C.: Insights into the genetic diversity of indigenous goats and their conservation priorities, Asian-Austral. J. Anim., 32, 1501–1510, https://doi.org/10.5713/ajas.18.0737, 2019.
Liu, H., Xu, H., Lan, X., Cao, X., and Pan, C.: The InDel variants of sheep IGF2BP1 gene are associated with growth traits, Anim. Biotechnol., 34, 134–142, https://doi.org/10.1080/10495398.2021.1942029, 2023.
Liu, Y., Wu, X., Xu, Q., Lan, X., and Li, W.: Temporal Transcriptome Dynamics of Longissimus dorsi Reveals the Mechanism of the Differences in Muscle Development and IMF Deposition between Fuqing Goats and Nubian Goats, Animals, 14, 1770, https://doi.org/10.3390/ani14121770, 2024.
Liu, Z., Xu, R., Zhang, H., Wang, D., Wang, J., and Wu, K.: A unique 15-bp InDel in the first intron of BMPR1B regulates its expression in Taihu pigs, BMC Genomics, 23, 799, https://doi.org/10.1186/s12864-022-08988-6, 2022.
Lopes-Marques, M., Cunha, I., Reis-Henriques, M. A., Santos, M. M., and Castro, L. F.: Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates, BMC Evol. Biol., 13, 271, https://doi.org/10.1186/1471-2148-13-271, 2013.
Luo, Q., Das, A., Oldoni, F., Wu, P., Wang, J., Luo, F., and Fang, Z.: Role of ACSL5 in fatty acid metabolism, Heliyon, 9, e13316, https://doi.org/10.1016/j.heliyon.2023.e13316, 2023.
Matesanz, F., Fedetz, M., Barrionuevo, C., Karaky, M., Catalá-Rabasa, A., Potenciano, V., Bello-Morales, R., López-Guerrero, J. A., and Alcina, A.: A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria, Eur. J. Hum. Genet., 24, 1572–1577, https://doi.org/10.1038/ejhg.2016.54, 2016.
Meller, N., Morgan, M. E., Wong, W. P., Altemus, J. B., and Sehayek, E.: Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption, Lipids Health Dis., 12, 88, https://doi.org/10.1186/1476-511x-12-88, 2013.
Mi, F., Wu, X., Wang, Z., Wang, R., and Lan, X.: Relationships between the Mini-InDel Variants within the Goat CFAP43 Gene and Body Traits, Animals, 12, 3447, https://doi.org/10.3390/ani12243447, 2022.
Mills, R. E., Luttig, C. T., Larkins, C. E., Beauchamp, A., Tsui, C., Pittard, W. S., and Devine, S. E.: An initial map of insertion and deletion (INDEL) variation in the human genome, Genome Res., 16, 1182–1190, https://doi.org/10.1101/gr.4565806, 2006.
Oikawa, E., Iijima, H., Suzuki, T., Sasano, H., Sato, H., Kamataki, A., Nagura, H., Kang, M. J., Fujino, T., Suzuki, H., and Yamamoto, T. T.: A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes, J. Biochem., 124, 679–685, https://doi.org/10.1093/oxfordjournals.jbchem.a022165, 1998.
Paul, D. S., Grevengoed, T. J., Pascual, F., Ellis, J. M., Willis, M. S., and Coleman, R. A.: Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin, Biochim. Biophys. Acta, 1841, 880–887, https://doi.org/10.1016/j.bbalip.2014.03.001, 2014.
Pérez-Núñez, I., Karaky, M., Fedetz, M., Barrionuevo, C., Izquierdo, G., Matesanz, F., and Alcina, A.: Splice-site variant in ACSL5: a marker promoting opposing effect on cell viability and protein expression, Eur. J. Hum. Genet., 27, 1836–1844, https://doi.org/10.1038/s41431-019-0414-5, 2019.
Qin, Q., Dai, D., Zhang, C., Zhao, C., Liu, Z., Xu, X., Lan, M., Wang, Z., Zhang, Y., Su, R., Wang, R., Wang, Z., Zhao, Y., Li, J., and Liu, Z.: Identification of body size characteristic points based on the Mask R-CNN and correlation with body weight in Ujumqin sheep, Frontiers in Veterinary Science, 9, 995724, https://doi.org/10.3389/fvets.2022.995724, 2022.
Reinke, H. and Asher, G.: Circadian Clock Control of Liver Metabolic Functions, Gastroenterology, 150, 574–580, https://doi.org/10.1053/j.gastro.2015.11.043, 2016.
Roh, E., Song, D. K., and Kim, M. S.: Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism, Experimental & molecular medicine, 48, e216, https://doi.org/10.1038/emm.2016.4, 2016.
Sheng, Y., Ren, H., Limbu, S. M., Sun, Y., Qiao, F., Zhai, W., Du, Z. Y., and Zhang, M.: The Presence or Absence of Intestinal Microbiota Affects Lipid Deposition and Related Genes Expression in Zebrafish (Danio rerio), Front. Microbiol., 9, 1124, https://doi.org/10.3389/fmicb.2018.01124, 2018.
Si-Tayeb, K., Lemaigre, F. P., and Duncan, S. A.: Organogenesis and development of the liver, Dev. Cell, 18, 175–189, https://doi.org/10.1016/j.devcel.2010.01.011, 2010.
Tao, L., He, X. Y., Jiang, Y. T., Lan, R., Li, M., Li, Z. M., Yang, W. F., Hong, Q. H., and Chu, M. X.: Combined approaches to reveal genes associated with litter size in Yunshang black goats, Anim. Genet., 51, 924–934, https://doi.org/10.1111/age.12999, 2020.
Wang, Z., Wang, R., Pan, C., Chen, H., Qu, L., Wu, L., Guo, Z., Zhu, H., and Lan, X.: Genetic Variations and mRNA Expression of Goat DNAH1 and Their Associations with Litter Size, Cells, 11, 1371, https://doi.org/10.3390/cells11081371, 2022.
Wijayanti, D., Erdenee, S., Akhatayeva, Z., Li, H., Li, J., Cai, Y., Jiang, F., Xu, H., and Lan, X.: Genetic polymorphisms within the ETAA1 gene associated with growth traits in Chinese sheep breeds, Anim. Genet., 53, 460–465, https://doi.org/10.1111/age.13197, 2022a.
Wijayanti, D., Zhang, S., Yang, Y., Bai, Y., Akhatayeva, Z., Pan, C., Zhu, H., Qu, L., and Lan, X.: Goat SMAD family member 1 (SMAD1): mRNA expression, genetic variants, and their associations with litter size, Theriogenology, 193, 11–19, https://doi.org/10.1016/j.theriogenology.2022.09.001, 2022b.
Wu, X., Jia, W., Zhang, J., Li, X., Pan, C., Lei, C., Chen, H., Dang, R., and Lan, X.: Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds, Small Ruminant Res., 121, 232–243, https://doi.org/10.1016/j.smallrumres.2014.09.002, 2014.
Wu, X., Liu, Y., Wang, Y., Zhang, F., and Li, W.: A novel 22-bp InDel within FGF7 gene is significantly associated with growth traits in goat, Anim. Biotechnol., 35, 2262537, https://doi.org/10.1080/10495398.2023.2262537, 2023a.
Yamashita, Y., Kumabe, T., Cho, Y. Y., Watanabe, M., Kawagishi, J., Yoshimoto, T., Fujino, T., Kang, M. J., and Yamamoto, T. T.: Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas, Oncogene, 19, 5919–5925, https://doi.org/10.1038/sj.onc.1203981, 2000.
Zhao, J., Liu, Z., Wang, X., Xin, X., Du, L., Zhao, H., An, Q., Ding, X., Zhang, Z., Wang, E., Xu, Z., and Huang, Y.: The Identification of Goat KCNJ15 Gene Copy Number Variation and Its Association with Growth Traits, Genes, 15, 250, https://doi.org/10.3390/genes15020250, 2024.
Zhou, Q., Hu, H., Yang, Y., Kang, Y., Lan, X., Wu, X., Guo, Z., and Pan, C.: Insertion/deletion (Indel) variant of the goat RORA gene is associated with growth traits, Anim. Biotechnol., 34, 2175–2182, https://doi.org/10.1080/10495398.2022.2078980, 2023.
Short summary
This study investigated the spatiotemporal expression pattern of ACSL5 (acyl-CoA synthetase 5) in goats and the association between its polymorphism and body measurement traits. We found that the ACSL5 gene was expressed ubiquitously in the nine tested tissues of Fuqing goats. The del41712 locus of the ACSL5 gene has a significant impact on multiple body measurement traits of goats, providing a basis for the application of marker-assisted selection in goat breeding.
This study investigated the spatiotemporal expression pattern of ACSL5 (acyl-CoA synthetase 5)...