Articles | Volume 68, issue 1
https://doi.org/10.5194/aab-68-125-2025
https://doi.org/10.5194/aab-68-125-2025
Original study
 | 
11 Feb 2025
Original study |  | 11 Feb 2025

The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing AP1S2

Baoyu Zhang, Runlai Liu, Tao Ma, Xinyu Li, Yuxin Zhao, Huixian Su, Jianping Li, Yumei Li, Huaizhi Jiang, and Qiaoling Zhang

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Cited articles

Aguennouz, M., Guarneri, F., Oteri, R., Polito, F., Giuffrida, R., and Cannavò, S. P.: Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes, J. Dermatol. Sci., 101, 22–29, https://doi.org/10.1016/j.jdermsci.2020.10.014, 2021. 
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Bertrand, J. U., Petit, V., Aktary, Z., de la Grange, P., Elkoshi, N., Sohier, P., Delmas, V., Levy, C., and Larue, L.: Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Graying and Changes in Integrin Expression, J. Invest. Dermatol., 144, 601–611, https://doi.org/10.1016/j.jid.2023.08.023, 2024. 
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Short summary
Coat color is an important economic trait of Cashmere goats. miRNA-211 is differentially expressed in the skin of Cashmere goats with different coat colors, but the mechanism is unclear. After the targeting relationship between miRNA-211 and AP1S2 was clarified in vitro and in vivo, antagomiRNA-211 was injected into BALB/c, and the expression of miRNA-211 and AP1S2 and melanin content was analyzed. It was demonstrated that miRNA-211 impacts melanogenesis by downregulating AP1S2.
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