The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing <i>AP1S2</i>

Zhang, Baoyu; Liu, Runlai; Ma, Tao; Li, Xinyu; Zhao, Yuxin; Su, Huixian; Li, Jianping; Li, Yumei; Jiang, Huaizhi; Zhang, Qiaoling

doi:https://doi.org/10.5194/aab-68-125-2025

Articles | Volume 68, issue 1

https://doi.org/10.5194/aab-68-125-2025

© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/aab-68-125-2025

© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 68, issue 1

Original study

|

11 Feb 2025

Original study |

| 11 Feb 2025

The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing AP1S2

Baoyu Zhang, Runlai Liu, Tao Ma, Xinyu Li, Yuxin Zhao, Huixian Su, Jianping Li, Yumei Li, Huaizhi Jiang, and Qiaoling Zhang

Supplement

https://doi.org/10.5194/aab-68-125-2025-supplement

Data sets

The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing AP1S2 Qiaoling Zhang https://doi.org/10.6084/m9.figshare.26312485

Short summary

Coat color is an important economic trait of Cashmere goats. miRNA-211 is differentially expressed in the skin of Cashmere goats with different coat colors, but the mechanism is unclear. After the targeting relationship between miRNA-211 and AP1S2 was clarified in vitro and in vivo, antagomiRNA-211 was injected into BALB/c, and the expression of miRNA-211 and AP1S2 and melanin content was analyzed. It was demonstrated that miRNA-211 impacts melanogenesis by downregulating AP1S2.