Articles | Volume 67, issue 4
https://doi.org/10.5194/aab-67-515-2024
https://doi.org/10.5194/aab-67-515-2024
Original study
 | 
21 Oct 2024
Original study |  | 21 Oct 2024

Exploring the association between SLC11A1 and CARD15 gene polymorphisms and tuberculosis susceptibility in Holstein cattle

Safa Bejaoui, Nour Elhouda Fehri, Mohamed Amine Ferchichi, and Bayrem Jemmali

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Cited articles

Abid, A., Kalthoum, S., Ben Salem, A., Guesmi, K., Lazgheb, A., Mansouri, R., and Benzarti, M.: Centre national de veille zoosanitaire en tunisie, Bulletin Zoo Sanitaire, 18, 1–10, http://cnvz.agrinet.tn/index.php/fr/item/1089-bulletin-zoo-sanitaire-n-18.html (last access: 24 May 2024), 2019. 
Allen, A. R., Minozzi, G., Glass, E. J., Skuce, R. A., McDowell, S. W. J., Woolliams, J. A., and Bishop, S. C.: Bovine tuberculosis: The genetic basis of host susceptibility, P. Roy. Soc. B, 277, 2737–2745, https://doi.org/10.1098/rspb.2010.0830, 2010. 
Azad, A. K., Sadee, W., and Schlesinger, L. S.: Innate immune gene polymorphisms in tuberculosis, Infect. Immun., 80, 3343–3359, https://doi.org/10.1128/IAI.00443-12, 2012. 
Baqir, M., Bhushan, S., Kumar, A., Sonawane, A., Singh, R., Chauhan, A., Yadav, R., Prakash, O., R, R., Baladhare, A., and Sharma, D.: Association of polymorphisms in SLC11A1 gene with bovine tuberculosis trait among Indian cattle, J. Appl. Anim. Res., 44, 380–383, https://doi.org/10.1080/09712119.2015.1091333, 2016. 
Bermingham, M. L., Bishop, S. C., Woolliams, J. A., Pong-Wong, R., Allen, A. R., McBride, S. H., Ryder, J. J., Wright, D. M., Skuce, R. A., McDowell, S. W., and Glass, E. J.: Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis, Heredity, 112, 543–551, https://doi.org/10.1038/hdy.2013.137, 2014. 
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Short summary
Genetic variation in the SLC11A1 (C>G) and CARD15 (A/G) genes may contribute to the onset and development of bovine tuberculosis (bTB), supporting the hypothesis that polymorphisms in these genes are associated with the risk of bTB in Holstein cattle. bTB is a complicated disease that is probably influenced by polymorphisms in many genes, particularly those related to the immune system and host–pathogen interactions.