Articles | Volume 67, issue 2
https://doi.org/10.5194/aab-67-217-2024
https://doi.org/10.5194/aab-67-217-2024
Original study
 | 
21 May 2024
Original study |  | 21 May 2024

Molecular characterization, function, tissue differential expression, and single-nucleotide polymorphism of buffalo TP53 gene

Lige Huang, Dan Sheng, Xinyang Fan, Ruixia Gao, and Yongwang Miao

Related authors

Polymorphism and molecular characteristics of the CSN1S2 gene in river and swamp buffalo
Xinyang Fan, Shanshan Gao, Lin Fu, Lihua Qiu, and Yongwang Miao
Arch. Anim. Breed., 63, 345–354, https://doi.org/10.5194/aab-63-345-2020,https://doi.org/10.5194/aab-63-345-2020, 2020
Short summary
Molecular characterization, tissue expression and polymorphisms of buffalo PPARGC1A gene
Lihua Qiu, Xinyang Fan, Yongyun Zhang, Xiaohong Teng, and Yongwang Miao
Arch. Anim. Breed., 63, 249–259, https://doi.org/10.5194/aab-63-249-2020,https://doi.org/10.5194/aab-63-249-2020, 2020
Short summary
Identification, molecular characteristics, and tissue differential expression of DGAT2 full-CDS cDNA sequence in Binglangjiang buffalo (Bubalus bubalis)
Fangting Zhou, Yongyun Zhang, Xiaohong Teng, and Yongwang Miao
Arch. Anim. Breed., 63, 81–90, https://doi.org/10.5194/aab-63-81-2020,https://doi.org/10.5194/aab-63-81-2020, 2020
Short summary
Polymorphisms of the kappa casein (CSN3) gene and inference of its variants in water buffalo (Bubalus bubalis)
Xinyang Fan, Zifang Zhang, Lihua Qiu, Yongyun Zhang, and Yongwang Miao
Arch. Anim. Breed., 62, 585–596, https://doi.org/10.5194/aab-62-585-2019,https://doi.org/10.5194/aab-62-585-2019, 2019
Short summary
Molecular cloning, sequence characterization, and tissue expression analysis of three water buffalo (Bubalus bubalis) genes – ST6GAL1, ST8SIA4, and SLC35C1
Shen Song, Yina Ou-Yang, Jinlong Huo, Yongyun Zhang, Changlin Yu, Minhui Liu, Xiaohong Teng, and Yongwang Miao
Arch. Anim. Breed., 59, 363–372, https://doi.org/10.5194/aab-59-363-2016,https://doi.org/10.5194/aab-59-363-2016, 2016

Related subject area

Functional genetics
Myostatin mutation (g+6723G  >  A) introgression: comparative analysis of growth, slaughter, and carcass traits in Texel, Pırlak, and their crosses (F1 and BC1)
Serdar Koçak, Mustafa Tekerli, Metin Erdoğan, Koray Çelikeloğlu, Ebubekir Yazıcı, Zehra Bozkurt, Özlem Hacan, Mustafa Demirtaş, and Samet Çinkaya
Arch. Anim. Breed., 67, 207–216, https://doi.org/10.5194/aab-67-207-2024,https://doi.org/10.5194/aab-67-207-2024, 2024
Short summary
Polymorphisms of the BMPR1B, BMP15 and GDF9 fecundity genes in four Chinese sheep breeds
Jinxin Wang, Yufang Liu, Siwu Guo, Ran Di, Xiangyu Wang, Xiaoyun He, and Mingxing Chu
Arch. Anim. Breed., 67, 51–60, https://doi.org/10.5194/aab-67-51-2024,https://doi.org/10.5194/aab-67-51-2024, 2024
Short summary
Polymorphism and expression of GLUD1 in relation to reproductive performance in Jining Grey goats
Wei Wang, Yongjuan Wang, Yufang Liu, Guiling Cao, Ran Di, Jinyu Wang, and Mingxing Chu
Arch. Anim. Breed., 66, 411–419, https://doi.org/10.5194/aab-66-411-2023,https://doi.org/10.5194/aab-66-411-2023, 2023
Short summary
Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats
Zühal Gündüz and Osman Biçer
Arch. Anim. Breed., 66, 369–378, https://doi.org/10.5194/aab-66-369-2023,https://doi.org/10.5194/aab-66-369-2023, 2023
Short summary
CircGUCY2C regulates cofilin 1 by sponging miR-425-3p to promote the proliferation of porcine skeletal muscle satellite cells
Kunlong Qi, Yaqing Dou, Chenlei Li, Yingke Liu, Chenglei Song, Xinjian Li, Kejun Wang, Ruimin Qiao, Xiuling Li, Feng Yang, and Xuelei Han
Arch. Anim. Breed., 66, 285–298, https://doi.org/10.5194/aab-66-285-2023,https://doi.org/10.5194/aab-66-285-2023, 2023
Short summary

Cited articles

Abdel-Hamid, M., Huang, L., Huang, Z., Romeih, E., Yang, P., Zeng, Q., and Li, L.: Effect of Buffalo Breed on the Detailed Milk Composition in Guangxi, China, Foods, 12, 1603–1612, https://doi.org/10.3390/foods12081603, 2023. 
Ahmad, S., Gaucher, I., Rousseau, F., Beaucher, E., Piot, M., Grongnet, J. F., and Gaucheron, F.: Effects of acidification on physico-chemical characteristics of buffalo milk: A comparison with cow's milk, Food Chem., 106, 11–17, https://doi.org/10.1016/j.foodchem.2007.04.021, 2008. 
Ammah, A. A., Do, D. N., Bissonnette, N., Gévry, N., and Ibeagha-Awemu, E. M.: Co-expression network analysis identifies miRNA-mRNA networks potentially regulating milk traits and blood metabolites, Int. J. Mol. Sci., 19, 2500–2527, https://doi.org/10.3390/ijms19092500, 2018. 
Appuhamy, J. A. D. R. N.: Regulatory roles of essential amino acids, energy, and insulin in mammary cell protein synthesis, PhD thesis, Virginia Tech, USA, 174 pp., 2010. 
Bionaz, M. and Loor, J. J.: Gene networks driving bovine mammary protein synthesis during the lactation cycle, Bioinform. Biol. Insig., 5, 83–98, https://doi.org/10.4137/BBI.S7003, 2011. 
Download
Short summary
The aim of this study was to investigate the role of TP53 in buffalo lactation. The data showed that buffalo TP53 inhibited the expression of genes related to milk protein and milk fat in buffalo mammary epithelial cells by inhibiting the PI3K–AKT–mTOR pathway. These results suggest that TP53 negatively regulates the synthesis of milk protein and milk fat in buffalo through the PI3K–AKT–mTOR pathway. This study provides new insights into the functional role of TP53 in buffalo lactation.