Articles | Volume 67, issue 2
https://doi.org/10.5194/aab-67-217-2024
https://doi.org/10.5194/aab-67-217-2024
Original study
 | 
21 May 2024
Original study |  | 21 May 2024

Molecular characterization, function, tissue differential expression, and single-nucleotide polymorphism of buffalo TP53 gene

Lige Huang, Dan Sheng, Xinyang Fan, Ruixia Gao, and Yongwang Miao

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Cited articles

Abdel-Hamid, M., Huang, L., Huang, Z., Romeih, E., Yang, P., Zeng, Q., and Li, L.: Effect of Buffalo Breed on the Detailed Milk Composition in Guangxi, China, Foods, 12, 1603–1612, https://doi.org/10.3390/foods12081603, 2023. 
Ahmad, S., Gaucher, I., Rousseau, F., Beaucher, E., Piot, M., Grongnet, J. F., and Gaucheron, F.: Effects of acidification on physico-chemical characteristics of buffalo milk: A comparison with cow's milk, Food Chem., 106, 11–17, https://doi.org/10.1016/j.foodchem.2007.04.021, 2008. 
Ammah, A. A., Do, D. N., Bissonnette, N., Gévry, N., and Ibeagha-Awemu, E. M.: Co-expression network analysis identifies miRNA-mRNA networks potentially regulating milk traits and blood metabolites, Int. J. Mol. Sci., 19, 2500–2527, https://doi.org/10.3390/ijms19092500, 2018. 
Appuhamy, J. A. D. R. N.: Regulatory roles of essential amino acids, energy, and insulin in mammary cell protein synthesis, PhD thesis, Virginia Tech, USA, 174 pp., 2010. 
Bionaz, M. and Loor, J. J.: Gene networks driving bovine mammary protein synthesis during the lactation cycle, Bioinform. Biol. Insig., 5, 83–98, https://doi.org/10.4137/BBI.S7003, 2011. 
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Short summary
The aim of this study was to investigate the role of TP53 in buffalo lactation. The data showed that buffalo TP53 inhibited the expression of genes related to milk protein and milk fat in buffalo mammary epithelial cells by inhibiting the PI3K–AKT–mTOR pathway. These results suggest that TP53 negatively regulates the synthesis of milk protein and milk fat in buffalo through the PI3K–AKT–mTOR pathway. This study provides new insights into the functional role of TP53 in buffalo lactation.