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Articles | Volume 67, issue 2
Articles | Volume 67, issue 2
https://doi.org/10.5194/aab-67-217-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-67-217-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 67, issue 2
Original study
 | 
21 May 2024
Original study |  | 21 May 2024

Molecular characterization, function, tissue differential expression, and single-nucleotide polymorphism of buffalo TP53 gene

Lige Huang, Dan Sheng, Xinyang Fan, Ruixia Gao, and Yongwang Miao

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Latest update: 29 Oct 2025
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Short summary
The aim of this study was to investigate the role of TP53 in buffalo lactation. The data showed that buffalo TP53 inhibited the expression of genes related to milk protein and milk fat in buffalo mammary epithelial cells by inhibiting the PI3K–AKT–mTOR pathway. These results suggest that TP53 negatively regulates the synthesis of milk protein and milk fat in buffalo through the PI3K–AKT–mTOR pathway. This study provides new insights into the functional role of TP53 in buffalo lactation.
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