Articles | Volume 66, issue 3
Original study
21 Sep 2023
Original study |  | 21 Sep 2023

Novel MHC BLB2 gene polymorphism and its association with IgY concentration and Newcastle disease antibody titer in IPB-D2 chickens

Dwi Lestari, Sri Murtini, Niken Ulupi, Asep Gunawan, and Cece Sumantri

Cited articles

Abumrad, N. N., and Barbul, A.: The Use of Arginine In Clinical Practice In Metabolic & Therapeutic Aspects of Amino Acids Clinical Nutrition, CRC Press, Boca Raton, Florida, 595–611, 2004. 
Allendorf, F. W., Luikart, G., and Aitken, S. N.: Conservation and The Genetics of Populations, Willey-Blackwell, New York, 225 United State, ISBN 978-0-470-67145-0 2012. 
Chen, F., Pan, L., Chao, W., Dai, Y., and Yu, W.: Character of chicken polymorphic major histocompability complex class II alleles of 3 Chinese local breeds, Poult. Sci., 91, 1097–1104, 2012. 
Da Silva, D. W. and Tambourgi, D. V.: IgY: a promosing antibody for use in immunodiagnostic and in immunotherapy, Vet. Immunol. Immunopathol., 135, 173–180, 2010. 
Guo, X. L., Zheng, H., Li, X. L., Gu, Z. L., Zheng, C. S., Wei, Z. H., Wang, J. S., Zhou, R. Y., and Li, L. H.: Genetic variation of major histocompability complex BLB2 gene exon 2 in Hebei domestic chicken, Res. Vet., 92, 76–79, 2012. 
Short summary
IPB-D2 chickens are one of the local Indonesian chickens that are being developed today. IPB-D2 chickens have disease-resistant traits. Selection is not only carried out conventionally but is also developed by molecular selection methods. By utilizing gene diversity in the major histocompatibility complex gene group, it was found that there were several single-nucleotide polymorphisms in the B Locus Beta 2 gene significantly associated with immunoglobulin Y concentrations in IPB-D2 chickens.