Articles | Volume 63, issue 1
https://doi.org/10.5194/aab-63-155-2020
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-63-155-2020
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original study
| 
26 May 2020
Original study |
| 26 May 2020
| 26 May 2020
Screening the key genes of hair follicle growth cycle in Inner Mongolian Cashmere goat based on RNA sequencing
Rui Su
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Key Laboratory of Animal Genetics, Breeding and Reproduction, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Key Laboratory of Mutton Sheep Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China
Engineering Research Center for Goat Genetics and Breeding, Hohhot, Inner Mongolia Autonomous Region, 010018, China
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Lingtian Zhang
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Xiaochun Yan
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Fenghong Wang
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Lei Zhang
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Xian Qiao
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Xiaokai Li
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Jinquan Li
CORRESPONDING AUTHOR
College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Key Laboratory of Animal Genetics, Breeding and Reproduction, Hohhot, Inner Mongolia Autonomous Region, 010018, China
Key Laboratory of Mutton Sheep Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China
Engineering Research Center for Goat Genetics and Breeding, Hohhot, Inner Mongolia Autonomous Region, 010018, China
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TIMP1 may affect goat prolificacy by regulating biological function of granulosa cells
CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression
MiR-25-3p regulates the differentiation of intramuscular preadipocytes in goat via targeting KLF4
EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes
A 20-bp insertion/deletion (indel) polymorphism within the CDC25A gene and its associations with growth traits in goat
Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter
DNA methylation pattern of the goat PITX1 gene and its effects on milk performance
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The effect of STEAP4 (six-transmembrane epithelial antigen of the prostate 4) on goat adipocyte differentiation is unclear. We cloned the goat STEAP4 gene based on the Jianzhou Da’er goat and analyzed its properties and its expression in tissues and adipocytes; further, the positive effect on the expression of subcutaneous adipocytes was obvious. This study will provide a basis for elucidating the biological function of the STEAP4 gene in goat and provide a reference for goat molecular breeding.
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Arch. Anim. Breed., 65, 309–318, https://doi.org/10.5194/aab-65-309-2022, https://doi.org/10.5194/aab-65-309-2022, 2022
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Arch. Anim. Breed., 65, 105–111, https://doi.org/10.5194/aab-65-105-2022, https://doi.org/10.5194/aab-65-105-2022, 2022
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Tissue inhibitor of metalloproteinase 1 (TIMP1) plays a crucial role in follicle growth and embryonic development. Ovarian granulosa cells also play an essential role in these processes. However, the effect of TIMP1 on the biological function of goat ovarian granulosa cells remains unknown. The objective of this study was to explore the impact of TIMP1 on granulosa cell proliferation and reproductive characteristics in goats.
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Cashmere is a natural fiber from cashmere goats. The textile has been favored by consumers due to typical features like lightness, softness, and comfort. In this study, we show that circRNA-0100 promotes the differentiation of secondary hair follicle stem cells into hair lineage via sequestering miR-153-3p to heighten the KLF5 expression. Our results provide significant information for artificially regulating the secondary hair follicle regeneration and cashmere growth in cashmere goats.
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Intramuscular fat is a type of fatty tissue deposited between skeletal muscle fibers and muscle bundles, which is regulated by the number and size of preadipocytes in the muscle, and it is a key factor affecting meat tenderness and juiciness. As a member of miRNAs, a variety of studies suggested that miR-25-3p may play an important role in regulating lipid metabolism and adipocyte differentiation. This study attempts to investigate the role of miR-25-3p in goat intramuscular preadipocytes.
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This study analyzed the DNA methylation profile of the PITX1 gene and its relevance to lactation performance in goats. The methylation rates of the overall CpG island and the 3rd and 12th CpG-dinucleotide loci in blood were significantly associated with average milk yield. The overall methylation rates of the CpG island in mammary gland tissue from dry and lactation periods showed a significant difference. These results could be used as potential epigenetic markers for lactation performance.
Fariborz Asroush, Seyed-Ziaeddin Mirhoseini, Nejat Badbarin, Alireza Seidavi, Vincenzo Tufarelli, Vito Laudadio, Cataldo Dario, and Maria Selvaggi
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The study aimed to genetically characterize Markhoz goat breed using specific microsatellite markers to investigate the genetic diversity within this population and to enhance future breeding strategies and conservation programmes. From findings, despite the decreasing population size, Markhoz goat genetic diversity seems still conserved and the breed seems to have a good level of genetic variability as well as a potential margin of adaptability to environment and future genetic improvement.
Hailong Yan, Enhui Jiang, Haijing Zhu, Linyong Hu, Jinwang Liu, and Lei Qu
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As we all know, genes often influence physiological functions of animal organisms such as reproduction, growth, and development. This study explored a novel insertion of paired-like homeodomain 2 (PITX2) gene, and many methods of statistical analysis were used to evaluate their associations with traits of goats. Results indicated that this insertion was significantly associated with litter size, body length, and chest width of goats.
Zhenyu Wei, Ke Wang, Yiqing Hui, Hailong Yan, Haijing Zhu, Lei Qu, Chuanying Pan, Hong Chen, and Xianyong Lan
Arch. Anim. Breed., 61, 311–319, https://doi.org/10.5194/aab-61-311-2018, https://doi.org/10.5194/aab-61-311-2018, 2018
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An effective DNA marker-assisted selection would speed up the development and improvement of goat products. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Results showed that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry.
Xian-Feng Wu, Yuan Liu, Cheng-Fang Gao, Xin-Zhu Chen, Xiao-Pei Zhang, and Wen-Yang Li
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ACOX1 is vital for fatty acid oxidation and deposition. The alternative splicing events of ACOX1 have not been reported in goats. Here, we found a novel splice variant (ACOX1-SV1) and a complete isoform (ACOX1). ACOX1 and ACOX1-SV1 were expressed at high levels in the liver, spleen, brain and fat in kid and adult goats. In both groups, the mRNA level of ACOX1 was high in fat and that of ACOX1-SV1 was high in liver. These findings should provide new insights on the function of ACOX1.
Hailong Yan, Fei Zhang, Ke Wang, Jinwang Liu, Haijing Zhu, Chuanying Pan, and Lei Qu
Arch. Anim. Breed., 61, 1–8, https://doi.org/10.5194/aab-61-1-2018, https://doi.org/10.5194/aab-61-1-2018, 2018
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In this study, a novel 12 bp indel within the LHX4 gene first intron was firstly found. Meanwhile, the association analysis indicated that the 12 bp indel was significantly associated with litter size in 1149 Shaanbei cashmere goats (P < 0.05). The litter sizes of genotype DD and ID individuals were superior to those of genotype II, implying that the 12 bp indel might affect litter size. These results could provide a new insight into implementing marker-assisted selection in goat breeding.
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Short summary
We tried to find important influencing factors of SHF growth cycle in skin tissue from Inner Mongolian Cashmere goats by RNA sequencing (RNA-Seq). Based on the results of comprehensive analysis of differentially expressed genes, GO enrichment and KEGG enrichment, we found that FGF5, FGFR1 and RRAS had an effect on the hair follicle growth cycle. The results of this study may provide a theoretical basis for further research on the growth and development of SHF in Inner Mongolian Cashmere goats.
We tried to find important influencing factors of SHF growth cycle in skin tissue from Inner...
