Articles | Volume 63, issue 1
Original study
26 May 2020
Original study |  | 26 May 2020

Screening the key genes of hair follicle growth cycle in Inner Mongolian Cashmere goat based on RNA sequencing

Rui Su, Gao Gong, Lingtian Zhang, Xiaochun Yan, Fenghong Wang, Lei Zhang, Xian Qiao, Xiaokai Li, and Jinquan Li

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Cited articles

Akilli Öztürk, Ö., Pakula, H., Chmielowiec, J., Qi, J. J., Stein, S., Lan, L. X., Sasaki, Y., Rajewsky, K., and Birchmeier, W.: Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence, Cell Rep., 13, 561–572,, 2015. 
Botchkarev, V. A., and Kishimoto, J.: Molecular control of epithelial-mesenchymal interactions during hair follicle cycling, J. Invest. Derm. Symp. P., 8, 46–55,, 2003. 
Chen, C. C., Plikus, M. V., Tang, P. C., Widelitz, R. B., and Chuong, C. M.: The modulatable stem cell niche: Tissue interactions during hair and feather follicle regeneration, J. Molecul. Biol., 428, 1423–1440,, 2016. 
Fang, G. J., Jia, X. Z., Li, H., Tan, S. W., Nie, Q. H., Yu, H., and Yang, Y.: Characterization of microRNA and mRNA expression profiles in skin tissue between early-feathering and late-feathering chickens, BMC Genom., 19, 1–12,, 2018. 
Geng, R. Q., Yuan, C., and Chen, Y. L.: Exploring differentially expressed genes by RNA-Seq in cashmere goat (Capra hircus) skin during hair follicle development and cycling, Plos One, 8, e62704,, 2013. 
Short summary
We tried to find important influencing factors of SHF growth cycle in skin tissue from Inner Mongolian Cashmere goats by RNA sequencing (RNA-Seq). Based on the results of comprehensive analysis of differentially expressed genes, GO enrichment and KEGG enrichment, we found that FGF5, FGFR1 and RRAS had an effect on the hair follicle growth cycle. The results of this study may provide a theoretical basis for further research on the growth and development of SHF in Inner Mongolian Cashmere goats.