Articles | Volume 61, issue 1
https://doi.org/10.5194/aab-61-59-2018
https://doi.org/10.5194/aab-61-59-2018
Original study
 | 
24 Jan 2018
Original study |  | 24 Jan 2018

Novel alternative splicing variants of ACOX1 and their differential expression patterns in goats

Xian-Feng Wu, Yuan Liu, Cheng-Fang Gao, Xin-Zhu Chen, Xiao-Pei Zhang, and Wen-Yang Li

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Cited articles

Baes, M. and Van Veldhoven, P. P.: Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies, BBA-Mol. Basis Dis., 1822, 1489–1500, 2012. 
Baranova, A., Tran, T. P., Afendy, A., Wang, L., Shamsaddini, A., Mehta, R., Chandhoke, V., Birerdinc, A., and Younossi, Z. M.: Molecular signature of adipose tissue in patients with both non-alcoholic fatty liver disease (NAFLD) and polycystic ovarian syndrome (PCOS), J. Transl. Med., 11, 133, https://doi.org/10.1186/1479-5876-11-133, 2013. 
Bush, S. J., Chen, L., Tovar-Corona, J. M., and Urrutia, A. O.: Alternative splicing and the evolution of phenotypic novelty, Philos. T. R. Soc. B., 372, 20150474, https://doi.org/10.1098/rstb.2015.0474, 2017. 
Bustin, S. A., Benes, V., Garson, J. A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M. W., and Shipley, G. L.: The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments, Clin. Chem., 55, 611–622, 2009. 
Cotter, K. A., Nacci, D., Champlin, D., Chuprin, J., and Callard, G. V.: Cloning of multiple ERα mRNA variants in killifish (Fundulus heteroclitus), and differential expression by tissue type, stage of reproduction, and estrogen exposure in fish from polluted and unpolluted environments, Aquat. Toxicol., 159, 184–197, 2015. 
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Short summary
ACOX1 is vital for fatty acid oxidation and deposition. The alternative splicing events of ACOX1 have not been reported in goats. Here, we found a novel splice variant (ACOX1-SV1) and a complete isoform (ACOX1). ACOX1 and ACOX1-SV1 were expressed at high levels in the liver, spleen, brain and fat in kid and adult goats. In both groups, the mRNA level of ACOX1 was high in fat and that of ACOX1-SV1 was high in liver. These findings should provide new insights on the function of ACOX1.