Articles | Volume 61, issue 1
https://doi.org/10.5194/aab-61-153-2018
https://doi.org/10.5194/aab-61-153-2018
Original study
 | 
28 Mar 2018
Original study |  | 28 Mar 2018

The novel T755C mutation in BMP15 is associated with the litter size of Iranian Afshari, Ghezel, and Shal breeds

Hamid-Reza Amini, Amir Ajaki, Majid Farahi, Mitra Heidari, Ahmad Pirali, Mohsen Forouzanfar, and Shahin Eghbalsaied

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Cited articles

Abdoli, R., Zamani, P., Mirhoseini, S., Ghavi Hossein-Zadeh, N., and Nadri, S.: A review on prolificacy genes in sheep, Reproduction in Domestic Animals, 51, 631–637, 2016. 
Abdoli, R., Mirhoseini, S. Z., Hossein-Zadeh, N. G., and Zamani, P.: Screening for causative mutations of major prolificacy genes in Iranian fat-tailed sheep, Int. J. Fertil. Steril., 12, 51–55, 2017. 
Ahmadi, A., Afraz, F., Talebi, R., Farahavar, A., and Vahidi, S.: Investigation of GDF9 and BMP15 polymorphisms in Mehraban sheep to find the missenses as impact on protein, Iranian Journal of Applied Animal Science, 6, 863–872, 2016. 
Asghari, S. R., Irajeyan, G. H., and Buesagh, H.: Genetic polymorphism FecB and BMP15 genes and its association with litter size in Sangsari sheep breed of Iran, J. Anim. Vet. Adv., 8, 1025–1031, 2009. 
Barzegari, A., Atashpaz, S., Ghabili, K., Nemati, Z., Rustaei, M., and Azarbaijani, R.: Polymorphisms in GDF9 and BMP15 associated with fertility and ovulation rate in Moghani and Ghezel sheep in Iran, Reprod. Domest. Anim., 45, 666–669, 2010. 
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Short summary
Birth of twins is partly controlled by genetic factors. Here, we genotyped ewes with triplet births, twin births, and single births as well as two infertile ewes from Iranian sheep breeds for the BMP15 gene. A new mutation was detected in two sterile ewes and all ewes with triplet-birth lambing. There is a relationship between the mutation and higher litter numbers. However, this mutation is not responsible for sterility or triplet births in Iranian sheep.