Articles | Volume 65, issue 4
https://doi.org/10.5194/aab-65-397-2022
https://doi.org/10.5194/aab-65-397-2022
Original study
 | 
04 Nov 2022
Original study |  | 04 Nov 2022

Overexpression of goat STEAP4 promotes the differentiation of subcutaneous adipocytes

Xin Li, Hao Zhang, Yong Wang, Yanyan Li, Yan Xiong, Ruiwen Li, Jiangjiang Zhu, and Yaqiu Lin

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Cited articles

Ayala-Sumuano, J. T., Velez-Del, Valle, C., Beltrán-Langarica, A., Hernández, J. M., and Kuri-Harcuch, W.: Adipogenic genes on induction and stabilization of commitment to adipose conversion, Biochem. Bioph. Res. Co., 374, 720–724, https://doi.org/10.1016/j.bbrc.2008.07.127, 2008. 
Boord, J. B., Fazio, S., and Linton, M. F.: Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis, Curr. Opin. Lipidol., 13, 141–147, https://doi.org/10.1097/00041433-200204000-00005, 2002. 
Chen, X. H., Zhu, C., Ji, C. B., Zhao, Y. P., Zhang, C. M., Chen, F. K., Gao, C. L., Zhu, J. G., Qian, L. M., and Guo, X. R.: STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes, Int. J. Mol. Med., 25, 361–367, https://doi.org/10.3892/ijmm_00000353, 2010. 
Furuhashi, M. and Hotamisligil, G. S.: Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets, Nat. Rev. Drug Discov., 7, 489–503, https://doi.org/10.1038/nrd2589, 2008. 
Garin-Shkolnik, T., Rudich, A., Hotamisligil, G. S., and Rubinstein, M.: FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues, Diabetes, 63, 900–911, https://doi.org/10.2337/db13-0436, 2014. 
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Short summary
The effect of STEAP4 (six-transmembrane epithelial antigen of the prostate 4) on goat adipocyte differentiation is unclear. We cloned the goat STEAP4 gene based on the Jianzhou Da’er goat and analyzed its properties and its expression in tissues and adipocytes; further, the positive effect on the expression of subcutaneous adipocytes was obvious. This study will provide a basis for elucidating the biological function of the STEAP4 gene in goat and provide a reference for goat molecular breeding.