Articles | Volume 65, issue 4
Arch. Anim. Breed., 65, 397–406, 2022
https://doi.org/10.5194/aab-65-397-2022
Arch. Anim. Breed., 65, 397–406, 2022
https://doi.org/10.5194/aab-65-397-2022
Original study
04 Nov 2022
Original study | 04 Nov 2022

Overexpression of goat STEAP4 promotes the differentiation of subcutaneous adipocytes

Xin Li et al.

Related authors

MiR-25-3p regulates the differentiation of intramuscular preadipocytes in goat via targeting KLF4
Yu Du, Yue Zhao, Yong Wang, Qingyong Meng, Jiangjiang Zhu, and Yaqiu Lin
Arch. Anim. Breed., 64, 17–25, https://doi.org/10.5194/aab-64-17-2021,https://doi.org/10.5194/aab-64-17-2021, 2021
Short summary

Related subject area

Subject: DNA markers and gene expressions | Animal: Goats
Meta-analysis of association between c.963A>G single-nucleotide polymorphism on BMP15 gene and litter size in goats
Emel Zergani, Amir Rashidi, Jalal Rostamzadeh, Mohammad Razmkabir, and Jens Tetens
Arch. Anim. Breed., 65, 309–318, https://doi.org/10.5194/aab-65-309-2022,https://doi.org/10.5194/aab-65-309-2022, 2022
Short summary
TIMP1 may affect goat prolificacy by regulating biological function of granulosa cells
Lei Hong, Xiang Chen, Min Zhu, Zheng Ao, Wen Tang, and Zhinan Zhou
Arch. Anim. Breed., 65, 105–111, https://doi.org/10.5194/aab-65-105-2022,https://doi.org/10.5194/aab-65-105-2022, 2022
Short summary
CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression
Junyin Zhao, Jincheng Shen, Zeying Wang, Man Bai, Yixing Fan, Yubo Zhu, and Wenlin Bai
Arch. Anim. Breed., 65, 55–67, https://doi.org/10.5194/aab-65-55-2022,https://doi.org/10.5194/aab-65-55-2022, 2022
Short summary
MiR-25-3p regulates the differentiation of intramuscular preadipocytes in goat via targeting KLF4
Yu Du, Yue Zhao, Yong Wang, Qingyong Meng, Jiangjiang Zhu, and Yaqiu Lin
Arch. Anim. Breed., 64, 17–25, https://doi.org/10.5194/aab-64-17-2021,https://doi.org/10.5194/aab-64-17-2021, 2021
Short summary
EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes
Zhihong Wu, Yu Wang, Wenjing Han, Kun Yang, Erhan Hai, Rong Ma, Zhengyang Di, Fangzheng Shang, Rui Su, Ruijun Wang, Zhiying Wang, Yanjun Zhang, and Jinquan Li
Arch. Anim. Breed., 63, 461–470, https://doi.org/10.5194/aab-63-461-2020,https://doi.org/10.5194/aab-63-461-2020, 2020
Short summary

Cited articles

Ayala-Sumuano, J. T., Velez-Del, Valle, C., Beltrán-Langarica, A., Hernández, J. M., and Kuri-Harcuch, W.: Adipogenic genes on induction and stabilization of commitment to adipose conversion, Biochem. Bioph. Res. Co., 374, 720–724, https://doi.org/10.1016/j.bbrc.2008.07.127, 2008. 
Boord, J. B., Fazio, S., and Linton, M. F.: Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis, Curr. Opin. Lipidol., 13, 141–147, https://doi.org/10.1097/00041433-200204000-00005, 2002. 
Chen, X. H., Zhu, C., Ji, C. B., Zhao, Y. P., Zhang, C. M., Chen, F. K., Gao, C. L., Zhu, J. G., Qian, L. M., and Guo, X. R.: STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes, Int. J. Mol. Med., 25, 361–367, https://doi.org/10.3892/ijmm_00000353, 2010. 
Furuhashi, M. and Hotamisligil, G. S.: Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets, Nat. Rev. Drug Discov., 7, 489–503, https://doi.org/10.1038/nrd2589, 2008. 
Garin-Shkolnik, T., Rudich, A., Hotamisligil, G. S., and Rubinstein, M.: FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues, Diabetes, 63, 900–911, https://doi.org/10.2337/db13-0436, 2014. 
Download
Short summary
The effect of STEAP4 (six-transmembrane epithelial antigen of the prostate 4) on goat adipocyte differentiation is unclear. We cloned the goat STEAP4 gene based on the Jianzhou Da’er goat and analyzed its properties and its expression in tissues and adipocytes; further, the positive effect on the expression of subcutaneous adipocytes was obvious. This study will provide a basis for elucidating the biological function of the STEAP4 gene in goat and provide a reference for goat molecular breeding.