Articles | Volume 65, issue 1
https://doi.org/10.5194/aab-65-105-2022
https://doi.org/10.5194/aab-65-105-2022
Original study
 | 
10 Mar 2022
Original study |  | 10 Mar 2022

TIMP1 may affect goat prolificacy by regulating biological function of granulosa cells

Lei Hong, Xiang Chen, Min Zhu, Zheng Ao, Wen Tang, and Zhinan Zhou

Related subject area

Subject: DNA markers and gene expressions | Animal: Goats
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Cited articles

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Anchamparuthy, V. M., Dhali, A., Lott, W. M., Pearson, R. E., and Gwazdauskas, F. C.: Vitrification of bovine oocytes: implications of follicular size and sire on the rates of embryonic development, J. Assist. Repord. Gen., 26, 613–619, 2009. 
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Cui, H. X., Zhao, S. M., Cheng, M. L., Guo, L., Ye, R. Q., Liu, W. Q., and Gao, S. Z.: Cloning and Expression Levels of Genes Relating to the Ovulation Rate of the Yunling Black Goat, Biol. Reprod., 80, 219–226, 2009. 
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Short summary
Tissue inhibitor of metalloproteinase 1 (TIMP1) plays a crucial role in follicle growth and embryonic development. Ovarian granulosa cells also play an essential role in these processes. However, the effect of TIMP1 on the biological function of goat ovarian granulosa cells remains unknown. The objective of this study was to explore the impact of TIMP1 on granulosa cell proliferation and reproductive characteristics in goats.