Articles | Volume 65, issue 1
https://doi.org/10.5194/aab-65-105-2022
https://doi.org/10.5194/aab-65-105-2022
Original study
 | 
10 Mar 2022
Original study |  | 10 Mar 2022

TIMP1 may affect goat prolificacy by regulating biological function of granulosa cells

Lei Hong, Xiang Chen, Min Zhu, Zheng Ao, Wen Tang, and Zhinan Zhou

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Cited articles

An, X. P., Hou, J. X., Li, G., Peng, J. Y., Liu, X. Q., Liu, H. Y., Xiao, W. P., Wang, J. G., Song, Y. X., and Cao, B. Y.: Analysis of Differentially Expressed Genes in Ovaries of Polytocous versus Monotocous Dairy Goats Using Suppressive Subtractive Hybridization, Repord. Domest. Anim., 47, 498–503, 2012. 
Anchamparuthy, V. M., Dhali, A., Lott, W. M., Pearson, R. E., and Gwazdauskas, F. C.: Vitrification of bovine oocytes: implications of follicular size and sire on the rates of embryonic development, J. Assist. Repord. Gen., 26, 613–619, 2009. 
Arpino, V., Brock, M., and Gill, S. E.: The role of TIMPs in regulation of extracellular matrix proteolysis, Matrix Biol., 44–46, 247–254, 2015. 
Cui, H. X., Zhao, S. M., Cheng, M. L., Guo, L., Ye, R. Q., Liu, W. Q., and Gao, S. Z.: Cloning and Expression Levels of Genes Relating to the Ovulation Rate of the Yunling Black Goat, Biol. Reprod., 80, 219–226, 2009. 
Curry, J., Song, L., and Wheeler, S. E.: Cellular localization of gelatinases and tissue inhibitors of metalloproteinases during follicular growth,ovulation, and early luteal formation in the rat, Biol. Reprod., 65, 855–865, 2001. 
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Short summary
Tissue inhibitor of metalloproteinase 1 (TIMP1) plays a crucial role in follicle growth and embryonic development. Ovarian granulosa cells also play an essential role in these processes. However, the effect of TIMP1 on the biological function of goat ovarian granulosa cells remains unknown. The objective of this study was to explore the impact of TIMP1 on granulosa cell proliferation and reproductive characteristics in goats.