Articles | Volume 64, issue 1
Arch. Anim. Breed., 64, 283–292, 2021
https://doi.org/10.5194/aab-64-283-2021
Arch. Anim. Breed., 64, 283–292, 2021
https://doi.org/10.5194/aab-64-283-2021

Original study 28 Jun 2021

Original study | 28 Jun 2021

Characteristics of Tibetan pig lung tissue in response to a hypoxic environment on the Qinghai–Tibet Plateau

Yanan Yang et al.

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Cited articles

Ai, H., Yang, B., Li, J., Xie, X., Chen, H., and Ren, J.: Population history and genomic signatures for high-altitude adaptation in Tibetan pigs, BMC Genomics., 15, 834, https://doi.org/10.1186/1471-2164-15-834, 2014. 
Auzmendi, J., Puchulu, M. B., Garcia, R. J., Balaszczuk, A. M., Lazarowski, A., and Merelli, A.: EPO and EPO-receptor system as potential actionable mechanism to protection of brain and heart in refractory epilepsy and SUDEP, Curr. Pharm. Des., 26, 1356–1364, https://doi.org/10.2174/1381612826666200219095548, 2020. 
Bai, M., Shang, P., Liu, J., Dan, Z., De, J., Wang, H., and Qiang, B.: Preliminary study on pulmonary tissue and hypoxia adaptation to plateau for Tibetan pigs, Hubei Agr. Sci., 51, 2776–2779, https://doi.org/10.14088/j.cnki.issn0439-8114.2012.13.064, 2012 (in Chinese with English Abstract). 
Beall, C. M., Brittenham, G. M., Strohl, K. P., Blangero, J., Williams-Blangero, S., Goldstein, M. C., Decker, M. J., Vargas, E., Villena, M., Soria, R., Alarcon, A. M., and Gonzales, C.: Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara, Am. J. Phys. Anthropol., 106, 385–400, https://doi.org/10.1002/(SICI)1096-8644(199807)106:3<385::AID-AJPA10>3.0.CO;2-X, 1998. 
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Short summary
Tibetan pigs are well adapted to high-altitude environments with a set of physiological features for more efficient blood flow for oxygen delivery under hypobaric hypoxia. We established the anatomy, physiology and molecular characteristics of the lung adaptive intelligence. Our finding suggest that the lung genetic mechanism of hypoxic adaptation in Tibetan pigs is valuable to understand.