Articles | Volume 64, issue 1
https://doi.org/10.5194/aab-64-231-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-64-231-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original study
| 
04 Jun 2021
Original study |
| 04 Jun 2021
| 04 Jun 2021
Dietary supplementary glutamine and L-carnitine enhanced the anti-cold stress of Arbor Acres broilers
Yang Liu
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Yuying Yang
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Ruizhi Yao
College of Animal Science and Technology, Inner Mongolia University
for Nationalities, Tongliao, 028000, PR China
Yajie Hu
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Peng Liu
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Shuai Lian
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Hongming Lv
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Bin Xu
CORRESPONDING AUTHOR
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Shize Li
CORRESPONDING AUTHOR
National Experimental Teaching Demonstration Center of Animal
Medicine Foundation, College of Animal Science and Veterinary Medicine,
Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China
Related subject area
Subject: Nutrition | Animal: Birds
Improved biological value of eggs due to the addition of pomegranate seed oil to laying-hen diets
Capsanthin supplementation modulates the immune response in broiler chickens under Escherichia coli lipopolysaccharide challenge
Effects of dietary thyme and rosemary essential oils on performance parameters with lipid oxidation, water activity, pH, colour and microbial quality of breast and drumstick meats in broiler chickens
Growth performance, carcass yield and characteristics, meat quality, serum biochemistry, jejunal histomorphometry, oxidative stability of liver and breast muscle, and immune response of broiler chickens fed natural antioxidant alone or in combination with Bacillus licheniformis
Dietary strategies to alleviate high-stocking-density-induced stress in broiler chickens – a comprehensive review
The effects of fermented milk products (kefir and yogurt) and probiotic on performance, carcass characteristics, blood parameters, and gut microbial population in broiler chickens
Effect of a low-energy and enzyme-supplemented diet on broiler chicken growth, carcass traits and meat quality
The effect of polyphenols and vitamin E on the antioxidant status and meat quality of broiler chickens fed low-quality oil
Methionine supplementation improves reproductive performance, antioxidant status, immunity and maternal antibody transmission in breeder Japanese quail under heat stress conditions
The effect of herbal feed additive on the growth performance, carcass characteristics and meat quality of broiler chickens fed low-energy diets
The effect of purslane hydroextract and zinc on performance, antioxidant capacity and immunity of broiler chickens during summer conditions
The effects of Saccharomyces cerevisiae on the morphological and biomechanical characteristics of the tibiotarsus in broiler chickens
Effect of dietary supplementation with Rhizopus oryzae or Chrysonilia crassa on growth performance, blood profile, intestinal microbial population, and carcass traits in broilers exposed to heat stress
Effects of purslane (Portulaca oleracea L.) powder on growth performance, blood indices, and antioxidant status in broiler chickens with triiodothyronine-induced ascites
Effects of nanoencapsulated aloe vera, dill and nettle root extract as feed antibiotic substitutes in broiler chickens
Effects of mannan oligosaccharide and Curcuma xanthorrhiza essential oil on the intestinal morphologyand stress indicators of broilers subjected to cyclic heat stress
Effects of in-yolk-sac administration of carvacrol on cholesterol resorption from yolk residuals and physiological adaptive indicators in broiler chicks exposed to neonatal fasting
The effects of in ovo feeding of glutamine in broiler breeder eggs on hatchability, development of the gastrointestinal tract, growth performance and carcass characteristics of broiler chickens
The effect of different levels of diet total volatile nitrogen on performance, carcass characteristics and meat total volatile nitrogen in broiler chickens
Improving the fatty acid profile in egg yolk through the use of hempseed (Cannabis sativa), ginger (Zingiber officinale), and turmeric (Curcuma longa) in the diet of Hy-Line White Leghorns
Effects of γ-aminobutyric acid on the tissue structure, antioxidant activity, cell apoptosis, and cytokine contents of bursa of Fabricius in chicks under heat stress
Comparison of the effects of basil (Ocimum basilicum) essential oil, avilamycin and protexin on broiler performance, blood biochemistry and carcass characteristics
Heat shock protein 70 mRNA expression and immune response of heat-stressed finishing broilers fed propolis (bee glue) supplementation
Effects of dietary soybean and sunflower oils with and without L-carnitine supplementation on growth performance and blood biochemical parameters of broiler chicks
Acidic stress caused by dietary administration of citric acid in broiler chickens
Application of sumac and dried whey in female broiler feed
Effects of the level and duration of feeding restriction on carcass components of broilers
Şaziye Canan Bölükbaşı, Büşra Dumlu, and Aycan Mutlu Yağanoğlu
Arch. Anim. Breed., 66, 121–129, https://doi.org/10.5194/aab-66-121-2023, https://doi.org/10.5194/aab-66-121-2023, 2023
Short summary
Short summary
The addition of 1 mL kg−1 pomegranate seed oil (PSO) to feeds improved performance. The addition of PSO had a positive effect on shelf life, and it increased punicic acid and conjugated linoleic acid (CLA) levels without reducing egg quality.
Brigitta Csernus, Csaba Szabó, Renáta Knop, Reda Gebrehaweria Kidane, Sawadi Fransisco Ndunguru, Gabriella Gulyás, Xénia Erika Ozsváth, and Levente Czeglédi
Arch. Anim. Breed., 66, 103–111, https://doi.org/10.5194/aab-66-103-2023, https://doi.org/10.5194/aab-66-103-2023, 2023
Short summary
Short summary
The application of antibiotics is being regulated continuously. Therefore, natural agents are being investigated that aim to strengthen the defense system of poultry. In our study, capsanthin was applied to investigate its effect on immune response under lipopolysaccharide immunization. Based on our results, capsanthin decreased the levels of pro-inflammatory cytokines at both mRNA and protein levels, which suggest the positive effects of capsanthin during inflammation in broiler chickens.
Recep Gumus and Sevda U. Gelen
Arch. Anim. Breed., 66, 17–29, https://doi.org/10.5194/aab-66-17-2023, https://doi.org/10.5194/aab-66-17-2023, 2023
Short summary
Short summary
This study was aimed at determining the effects of different doses of thyme essential oil (TEO) and rosemary essential oil (REO) incorporated into broiler rations on performance parameters, including body weight gain, feed intake and feed conversion rate, as well as on the quality criteria of breast and drumstick meat. As a result, dietary supplementation with TEO and REO was determined to have a limited effect on performance parameters but to improve the microbial quality of meat.
Umair Ahsan, Shahram Golzar Adabi, Özge Sayın Özdemir, Ömer Sevim, Onur Tatlı, Eren Kuter, and Özcan Cengiz
Arch. Anim. Breed., 65, 183–197, https://doi.org/10.5194/aab-65-183-2022, https://doi.org/10.5194/aab-65-183-2022, 2022
Short summary
Short summary
Phytogenics emerged as a substitute of in-feed antibiotics following the ban on their use at subtherapeutic levels in poultry diets. However, the effects of phytogenics have been uncertain in studies conducted so far. Combined use of phytogenics and probiotics may be effective in this regard. In a nutshell, this study shows that combined use of phytogenics and Bacillus licheniformis possess the potential to improve oxidative stability of breast meat and immune response of broiler chickens.
Sugiharto Sugiharto
Arch. Anim. Breed., 65, 21–36, https://doi.org/10.5194/aab-65-21-2022, https://doi.org/10.5194/aab-65-21-2022, 2022
Short summary
Short summary
Stocking broilers at a high density has been a strategy to optimize the area of the cage. If the environment and rearing management are not properly managed, stocking broilers at a high density may, however, result in stressful conditions that are harmful for the production and health of broilers. To ameliorate these unfavourable effects of overcrowding stress, dietary interventions using probiotics, prebiotics, synbiotics, herbs, vitamins, etc. have been conducted.
Mohammad Ghasemi-Sadabadi, Yahya Ebrahimnezhad, Abdolahad Shaddel-Tili, Vahid Bannapour-Ghaffari, Hashem Kozehgari, and Mirmojtaba Didehvar
Arch. Anim. Breed., 62, 361–374, https://doi.org/10.5194/aab-62-361-2019, https://doi.org/10.5194/aab-62-361-2019, 2019
Elsayed O. S. Hussein, Gamaleldin M. Suliman, Alaeldein M. Abudabos, Abdullah N. Alowaimer, Shamseldein H. Ahmed, Mohamed E. Abd El-Hack, Mahmoud Alagawany, Ayman A. Swelum, Antonella Tinelli, Vincenzo Tufarelli, and Vito Laudadio
Arch. Anim. Breed., 62, 297–304, https://doi.org/10.5194/aab-62-297-2019, https://doi.org/10.5194/aab-62-297-2019, 2019
Short summary
Short summary
This study evaluated the impact of a low metabolizable energy diet supplemented with a multienzyme blend on the growth performance, carcass traits and meat quality of chickens. From findings, the low metabolizable energy supplemented with the enzyme complex did not influence most of performance parameters and carcass traits of chickens; however, adding enzymes to a low-energy diet is an effective strategy to improve the meat quality criteria and small intestine characteristics.
Magdalena Mazur-Kuśnirek, Zofia Antoszkiewicz, Krzysztof Lipiński, Joanna Kaliniewicz, and Sylwia Kotlarczyk
Arch. Anim. Breed., 62, 287–296, https://doi.org/10.5194/aab-62-287-2019, https://doi.org/10.5194/aab-62-287-2019, 2019
Short summary
Short summary
Increased dietary inclusion levels of vitamin E and/or polyphenols improved the antioxidant status of broilers fed low-quality oil. Dietary supplementation with vitamin E and/or polyphenols improved meat quality by better colour, higher concentrations of n-6 polyunsaturated fatty acids, hypocholesterolemic fatty acids and a lower atherogenicity index. Polyphenols combined with vitamin E can be a valuable component of diets for broiler chickens when the problem of low-quality oil occurs.
Omid Kalvandi, Amirali Sadeghi, and Ahmad Karimi
Arch. Anim. Breed., 62, 275–286, https://doi.org/10.5194/aab-62-275-2019, https://doi.org/10.5194/aab-62-275-2019, 2019
Short summary
Short summary
Dietary supplementation with either 1.15, 1.30 or 1.45 times the Met requirements (as NRC recommendation) in breeder quails can alleviate the adverse effects of heat stress and improve the performance, reproduction, antioxidant status and immunity, as well as maternal antibody transmission. Supplementation of diet with 1.30 times the Met requirements could be used as a nutritional strategy in breeder quails for the alleviation of the adverse effects of heat stress.
Krzysztof Lipiński, Zofia Antoszkiewicz, Sylwia Kotlarczyk, Magdalena Mazur-Kuśnirek, Joanna Kaliniewicz, and Zbigniew Makowski
Arch. Anim. Breed., 62, 33–40, https://doi.org/10.5194/aab-62-33-2019, https://doi.org/10.5194/aab-62-33-2019, 2019
Short summary
Short summary
Herbs and herbal feed additives are a valuable component in broiler chicken diets, affecting, e.g., health status, productivity and meat quality. In our study a herbal formula was applied in broiler chickens fed lower energy concentration diets. An interaction between experimental factors was not found, although a gainful effect on the productivity was noticed in broiler chickens fed diets with a herbal formula.
Rojin Kazemi, Ardashir Sheikhahmadi, and Ghorbanali Sadeghi
Arch. Anim. Breed., 61, 365–371, https://doi.org/10.5194/aab-61-365-2018, https://doi.org/10.5194/aab-61-365-2018, 2018
Bayram Suzer, Ilker Arican, Derya Yesilbag, and Huseyin Yildiz
Arch. Anim. Breed., 60, 439–446, https://doi.org/10.5194/aab-60-439-2017, https://doi.org/10.5194/aab-60-439-2017, 2017
Short summary
Short summary
This study focused on examining the effects of different levels of Saccharomyces cerevisiae on broiler tibiotarsus traits and the reduction of leg problems by identifying the pathological changes in the leg skeletal system. Yeast supplementation led to an improvement in the bone traits of broiler chickens. Therefore, the use of yeast as a feed supplement in broilers is considered an economic and convenient way of providing animal welfare and preventing commercial losses due to leg problems.
Sugiharto Sugiharto, Turrini Yudiarti, Isroli Isroli, Endang Widiastuti, and Fatan Dwi Putra
Arch. Anim. Breed., 60, 347–356, https://doi.org/10.5194/aab-60-347-2017, https://doi.org/10.5194/aab-60-347-2017, 2017
Short summary
Short summary
Fungal supplementation especially with the fungus C. crassa could improve antioxidant status and physiological conditions of heat-stressed broilers. Such dietary supplementation may, therefore, be beneficial for ameliorating the adverse effects of heat stress in broiler chickens.
Mahmood Habibian, Ghorbanali Sadeghi, and Ahmad Karimi
Arch. Anim. Breed., 60, 315–325, https://doi.org/10.5194/aab-60-315-2017, https://doi.org/10.5194/aab-60-315-2017, 2017
Short summary
Short summary
Ascites is a metabolic disorder in chickens. Hypoxemia and oxidative stress are specific characteristics in birds that develop ascites. We hypothesized that purslane, as one natural source of antioxidant and antihypoxic compounds, would attenuate the incidence and/or severity of T3-induced ascites in broilers. Supplementation of purslane powder to diet improved antioxidant status and attenuated the symptoms of ascites. However, it could not prevent the decrease in growth performance.
Amir Meimandipour, Ali Nouri Emamzadeh, and Ali Soleimani
Arch. Anim. Breed., 60, 1–7, https://doi.org/10.5194/aab-60-1-2017, https://doi.org/10.5194/aab-60-1-2017, 2017
Seyed Mohammad Hosseini, Hasan Nazarizadeh, Saeede Ahani, and Masoume Vakili Azghandi
Arch. Anim. Breed., 59, 285–291, https://doi.org/10.5194/aab-59-285-2016, https://doi.org/10.5194/aab-59-285-2016, 2016
Mir Hasan Beiranvand, Heshmatollah Khosravinia, Arash Azarfar, and Ezatollah Rafiei Alavai
Arch. Anim. Breed., 59, 249–257, https://doi.org/10.5194/aab-59-249-2016, https://doi.org/10.5194/aab-59-249-2016, 2016
Short summary
Short summary
The results of this study revealed that in-yolk-sac administration of carvacrol, as the main phenolic monoterpen in Satureja khuzestanica, had no effect on the rate of cholesterol absorption from yolk sac residuals in neonate commercial broiler chicks. This finding suggests that the hypocholesterolemic activity of carvacrol in broiler chicks might be exerted through other mechanisms rather than reduced cholesterol absorption and deserves further investigation.
Mehdi Salmanzadeh, Yahya Ebrahimnezhad, Habib Aghdam Shahryar, and Jamshid Ghiasi Ghaleh-Kandi
Arch. Anim. Breed., 59, 235–242, https://doi.org/10.5194/aab-59-235-2016, https://doi.org/10.5194/aab-59-235-2016, 2016
Short summary
Short summary
Effect of in ovo feeding of glutamine on hatchability, performance of broilers. Fertilized eggs were subjected to injections with glutamine (10, 20, 30, 40 or 50 mg dissolved in 0.5 mL of dionized water) on day 7 of incubation. These data suggest that the in ovo feeding of Glutamine may improve jejunum development, leading to an increased nutrient assimilation and consequently to greater performance in broiler chickens.
Farhad Fallah, Yahya Ebrahimnezhad, Naser Maheri-Sis, and Mohammad Ghasemi-Sadabadi
Arch. Anim. Breed., 59, 191–199, https://doi.org/10.5194/aab-59-191-2016, https://doi.org/10.5194/aab-59-191-2016, 2016
Tausif Raza, Naila Chand, Rifat Ullah Khan, Muhammad Suhaib Shahid, and Alaeldein M. Abudabos
Arch. Anim. Breed., 59, 183–190, https://doi.org/10.5194/aab-59-183-2016, https://doi.org/10.5194/aab-59-183-2016, 2016
Zhong Chen, Yong-Wei Zhou, Chen Liang, Ying-Ya Jiang, and Li-Jin Xie
Arch. Anim. Breed., 59, 97–105, https://doi.org/10.5194/aab-59-97-2016, https://doi.org/10.5194/aab-59-97-2016, 2016
S. R. Riyazi, Y. Ebrahimnezhad, S. A. Hosseini, A. Meimandipour, and A. Ghorbani
Arch. Anim. Breed., 58, 425–432, https://doi.org/10.5194/aab-58-425-2015, https://doi.org/10.5194/aab-58-425-2015, 2015
S. M. Hosseini, M. Afshar, S. Ahani, and M. Vakili Azghandi
Arch. Anim. Breed., 58, 407–413, https://doi.org/10.5194/aab-58-407-2015, https://doi.org/10.5194/aab-58-407-2015, 2015
S. M. A. Jalali, R. Rabiei, and F. Kheiri
Arch. Anim. Breed., 58, 387–394, https://doi.org/10.5194/aab-58-387-2015, https://doi.org/10.5194/aab-58-387-2015, 2015
Short summary
Short summary
Dietary plant oil sources and supplementation with L-carnitine have interaction effects on the physiological response and growth performance of broiler chicks. Addition of L-carnitine to diets which contained soybean oil showed the best growth performance of chicks in comparison to sunflower oil mixes.
R. Nourmohammadi and H. Khosravinia
Arch. Anim. Breed., 58, 309–315, https://doi.org/10.5194/aab-58-309-2015, https://doi.org/10.5194/aab-58-309-2015, 2015
F. Kheiri, Y. Rahimian, and J. Nasr
Arch. Anim. Breed., 58, 205–210, https://doi.org/10.5194/aab-58-205-2015, https://doi.org/10.5194/aab-58-205-2015, 2015
H. Jahanpour, A. Seidavi, A. A. A. Qotbi, R. Van Den Hoven, S. Rocha e Silva, V. Laudadio, and V. Tufarelli
Arch. Anim. Breed., 58, 99–105, https://doi.org/10.5194/aab-58-99-2015, https://doi.org/10.5194/aab-58-99-2015, 2015
Cited articles
Agarwal, A., Sengupta, P., and Durairajanayagam, D.: Role of L-carnitine in
female infertility, Reprod. Biol. Endocrin., 16, 5,
https://doi.org/10.1186/s12958-018-0323-4, 2018.
Angelier, F., Parenteau, C., Ruault, S., and Angelier, N.: Endocrine
consequences of an acute stress under different thermal conditions: A study
of corticosterone, prolactin, and thyroid hormones in the pigeon (Columbia
livia), Comp. Biochem. Phys. A, 196, 38–45, https://doi.org/10.1016/j.cbpa.2016.02.010, 2016.
Babacanoğlu, E., Yalçin, S., and Uysal, S.: Evaluation of a stress
model induced by dietary corticosterone supplementation in broiler breeders:
effects on egg yolk corticosterone concentration and biochemical blood
parameters, Brit. Poultry Sci., 54, 677–685,
https://doi.org/10.1080/00071668.2013.847901, 2013.
Bailey, L. D., Ens, B. J., Both, C., Heg, D., Oosterbeek, K., and van de
Pol, M.: Habitat selection can reduce effects of extreme climatic events in
a long-lived shorebird, J. Anim. Ecol., 88, 1474–1485,
https://doi.org/10.1111/1365-2656.13041, 2019.
Banihani, S., Sharma, R., Bayachou, M., Sabanegh, E., and Agarwal, A.: Human
sperm DNA oxidation, motility and viability in the presence of L-carnitine
during in vitro incubation and centrifugation, Andrologia, 44, Suppl. 1,
505–512, https://doi.org/10.1111/j.1439-0272.2011.01216.x, 2012.
Bartell, S. M. and Batal, A. B.: The effect of supplemental glutamine on
growth performance, development of the gastrointestinal tract, and humoral
immune response of broilers, Poultry Sci., 86, 1940–1947,
https://doi.org/10.1093/ps/86.9.1940, 2007.
Beier, E. E., Sheu, T. J., Resseguie, E. A., Takahata, M., Awad, H. A.,
Cory-Slechta, D. A., and Puzas, J. E.: Sclerostin activity plays a key role
in the negative effect of glucocorticoid signaling on osteoblast function in
mice, Bone Res., 5, 17013, https://doi.org/10.1038/boneres.2017.13, 2017.
Buijs, N., Wörner, E. A., Brinkmann, S. J., Luttikhold, J., van der
Meij, B. S., Houdijk, A. P., and van Leeuwen, P. A.: Novel nutritional
substrates in surgery, P. Nutr. Soc., 72,
277–287, https://doi.org/10.1017/s0029665112003047, 2013.
Carr, E. L., Kelman, A., Wu, G. S., Gopaul, R., Senkevitch, E., Aghvanyan,
A., Turay, A. M., and Frauwirth, K. A.: Glutamine uptake and metabolism are
coordinately regulated by ERK/MAPK during T lymphocyte activation, J. Immunol., 185, 1037–1044,
https://doi.org/10.4049/jimmunol.0903586, 2010.
Celik, L. and Oztürkcan, O.: Effects of dietary supplemental L-carnitine
and ascorbic acid on performance, carcass composition and plasma L-carnitine
concentration of broiler chicks reared under different temperature, Arch. Tierernahr., 57, 27–38, https://doi.org/10.1080/0003942031000086644, 2003.
Chatzitomaris, A., Hoermann, R., Midgley, J. E., Hering, S., Urban, A.,
Dietrich, B., Abood, A., Klein, H. H., and Dietrich, J. W.: Thyroid
Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions
of Strain, Stress, and Developmental Programming, Front Endocrinol., 8, 163, https://doi.org/10.3389/fendo.2017.00163, 2017.
Cong, P., Liu, Y., Liu, N., Zhang, Y., Tong, C., Shi, L., Liu, X., Shi, X.,
Liu, Y., Tong, Z., and Hou, M.: Cold exposure induced oxidative stress and
apoptosis in the myocardium by inhibiting the Nrf2-Keap1 signaling pathway,
BMC Cardiovasc. Disor., 18, 36, https://doi.org/10.1186/s12872-018-0748-x, 2018.
Coqueiro, A. Y., Rogero, M. M., and Tirapegui, J.: Glutamine as an
Anti-Fatigue Amino Acid in Sports Nutrition, Nutrients, 11, 863,
https://doi.org/10.3390/nu11040863, 2019.
Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R., and Newsholme, P.:
Glutamine: Metabolism and Immune Function, Supplementation and Clinical
Translation, Nutrients, 10, 1564, https://doi.org/10.3390/nu10111564, 2018.
Fan, J., Wu, L., Li, G., Tao, S., Sheng, Z., Meng, Q., Li, F., Yu, L., and
Li, L.: Effects of enteral nutrition with parenteral glutamine
supplementation on the immunological function in septic rats, Brit.
J. Nutr., 113, 1712–1722, https://doi.org/10.1017/s0007114515001099, 2015.
García-Díaz, E. C., Gómez-Quiroz, L. E., Arenas-Ríos, E.,
Aragón-Martínez, A., Ibarra-Arias, J. A., and del Socorro, I. R.-M.
M.: Oxidative status in testis and epididymal sperm parameters after acute
and chronic stress by cold-water immersion in the adult rat, Syst. Biol.
Reprod. Mec., 61, 150–160, https://doi.org/10.3109/19396368.2015.1008071, 2015.
Gavrilova, S. I.: The therapeutic potential of acetyl-L-carnitine in the
treatment of cognitive and depressive disorders in the elderly, Zhurnal
nevrologii i psikhiatrii imeni S.S. Korsakova, 118, 37–45,
https://doi.org/10.17116/jnevro201811806237, 2018.
Hangalapura, B. N., Nieuwland, M. G., de Vries Reilingh, G., Heetkamp, M.
J., van den Brand, H., Kemp, B., and Parmentier, H. K.: Effects of cold
stress on immune responses and body weight of chicken lines divergently
selected for antibody responses to sheep red blood cells, Poultry Sci.,
82, 1692–1700, https://doi.org/10.1093/ps/82.11.1692, 2003.
Hansen, B. B., Gamelon, M., Albon, S. D., Lee, A. M., Stien, A., Irvine, R.
J., Sæther, B. E., Loe, L. E., Ropstad, E., Veiberg, V., and Grøtan,
V.: More frequent extreme climate events stabilize reindeer population
dynamics, Nat. Commun., 10, 1616, https://doi.org/10.1038/s41467-019-09332-5, 2019.
Hao, Q., Yadav, R., Basse, A. L., Petersen, S., Sonne, S. B., Rasmussen, S.,
Zhu, Q., Lu, Z., Wang, J., Audouze, K., Gupta, R., Madsen, L., Kristiansen,
K., and Hansen, J. B.: Transcriptome profiling of brown adipose tissue
during cold exposure reveals extensive regulation of glucose metabolism,
Am. J. Phys.-Endoc. M., 308, 380–392,
https://doi.org/10.1152/ajpendo.00277.2014, 2015.
Honda, B. T., Calefi, A. S., Costola-de-Souza, C., Quinteiro-Filho, W. M.,
da Silva Fonseca, J. G., de Paula, V. F., and Palermo-Neto, J.: Effects of
heat stress on peripheral T and B lymphocyte profiles and IgG and IgM serum
levels in broiler chickens vaccinated for Newcastle disease virus, Poultry
Sci., 94, 2375–2381, https://doi.org/10.3382/ps/pev192, 2015.
Izgüt-Uysal, V. N., Bülbül, M., Tan, R., Derin, N., Ustünel,
I., Ağar, A., and Yargiçoğlu, P.: Effect of chronic stress and
L-carnitine on rat stomach, J. Physiol. Sci., 57,
187–192, https://doi.org/10.2170/physiolsci.RP004707, 2007.
Jia, R., Bao, Y. H., Zhang, Y., Ji, C., Zhao, L. H., Zhang, J. Y., Gao, C.
Q., and Ma, Q. G.: Effects of dietary α-lipoic acid,
acetyl-l-carnitine, and sex on antioxidative ability, energy, and lipid
metabolism in broilers, Poultry Sci., 93, 2809–2817,
https://doi.org/10.3382/ps.2014-03921, 2014.
Jiang, K. J., Jiao, H. C., Song, Z. G., Yuan, L., Zhao, J. P., and Lin, H.:
Corticosterone administration and dietary glucose supplementation enhance
fat accumulation in broiler chickens, British Poultry Sci., 49, 625–631, https://doi.org/10.1080/00071660802337241, 2008.
Katalinic, L., Krtalic, B., Jelakovic, B., and Basic-Jukic, N.: The
Unexpected Effects of L-Carnitine Supplementation on Lipid Metabolism in
Hemodialysis Patients, Kidney Blood Pres. Res., 43, 1113–1120,
https://doi.org/10.1159/000491807, 2018.
Kazemi Fard, M. Y. S., Dirandeh, E., and Rezaei, M.: Effect of Different
Levels of L-Carnitine on the Productive Performance, Egg Quality, Blood
Parameters and Egg Yolk Cholesterol in Laying Hens, Poultry Sci. J.,
2015, 105–111, 2015.
Kelek, S. E., Afşar, E., Akçay, G., Danışman, B., and Aslan,
M.: Effect of chronic L-carnitine supplementation on carnitine levels,
oxidative stress and apoptotic markers in peripheral organs of adult Wistar
rats, Food Chem. Toxicol., 134, 110851, https://doi.org/10.1016/j.fct.2019.110851, 2019.
Khalatbari-Soltani, S. and Tabibi, H.: Inflammation and L-carnitine therapy
in hemodialysis patients: a review, Clin. Exp. Nephrol.,
19, 331–335, https://doi.org/10.1007/s10157-014-1061-3, 2015.
King, M. O. and Swanson, D. L.: Activation of the immune system incurs
energetic costs but has no effect on the thermogenic performance of house
sparrows during acute cold challenge, J. Exp. Biol.,
216, 2097–2102, https://doi.org/10.1242/jeb.079574, 2013.
Lambertucci, A. C., Lambertucci, R. H., Hirabara, S. M., Curi, R., Moriscot,
A. S., Alba-Loureiro, T. C., Guimarães-Ferreira, L., Levada-Pires, A.
C., Vasconcelos, D. A., Sellitti, D. F., and Pithon-Curi, T. C.: Glutamine
supplementation stimulates protein-synthetic and inhibits
protein-degradative signaling pathways in skeletal muscle of diabetic rats,
PLoS One, 7, e50390, https://doi.org/10.1371/journal.pone.0050390, 2012.
Li, J. M., Li, L. Y., Qin, X., Ning, L. J., Lu, D. L., Li, D. L., Zhang, M.
L., Wang, X., and Du, Z. Y.: Systemic regulation of L-carnitine in
nutritional metabolism in zebrafish, Danio rerio, Sci. Rep.-UK, 7,
40815, https://doi.org/10.1038/srep40815, 2017.
Li, L., Meng, Y., Li, Z., Dai, W., Xu, X., Bi, X., and Bian, J.: Discovery
and development of small molecule modulators targeting glutamine metabolism,
Eur. J. Med. Chem., 163, 215–242, https://doi.org/10.1016/j.ejmech.2018.11.066, 2019.
Lian, S., Guo, J., Wang, L., Li, W., Wang, J., Ji, H., Kong, F., Xu, B., Li,
S., and Yang, H.: Impact of prenatal cold stress on placental physiology,
inflammatory response, and apoptosis in rats, Oncotarget, 8, 115304–115314,
https://doi.org/10.18632/oncotarget.23257, 2017.
Lin, H., Decuypere, E., and Buyse, J.: Oxidative stress induced by
corticosterone administration in broiler chickens (Gallus gallus domesticus)
1. Chronic exposure, Comp. Biochem. Phys. B,
139, 737–744, https://doi.org/10.1016/j.cbpc.2004.09.013, 2004.
Liu, P., Yao, R., Shi, H., Liu, Y., Lian, S., Yang, Y., Yang, H., and Li,
S.: Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis
during Acute Cold Exposure in C57BL/6 Mice, Int. J. Mol. Sci., 20,
https://doi.org/10.3390/ijms20061470, 2019.
Madsen, K. L., Preisler, N., Rasmussen, J., Hedermann, G., Olesen, J. H.,
Lund, A. M., and Vissing, J.: L-Carnitine Improves Skeletal Muscle Fat
Oxidation in Primary Carnitine Deficiency, J. Clin.
Endocr. Metab., 103, 4580–4588, https://doi.org/10.1210/jc.2018-00953, 2018.
Maruyama, T., Maruyama, N., Higuchi, T., Nagura, C., Takashima, H., Kitai,
M., Utsunomiya, K., Tei, R., Furukawa, T., Yamazaki, T., Okawa, E., Ando,
H., Kikuchi, F., and Abe, M.: Efficacy of L-carnitine supplementation for
improving lean body mass and physical function in patients on hemodialysis:
a randomized controlled trial, Eur. J. Clin. Nutr., 73,
293–301, https://doi.org/10.1038/s41430-018-0348-y, 2019.
Mehaisen, G. M., Eshak, M. G., Elkaiaty, A. M., Atta, A. M., Mashaly, M. M.,
and Abass, A. O.: Comprehensive growth performance, immune function, plasma
biochemistry, gene expressions and cell death morphology responses to a
daily corticosterone injection course in broiler chickens, PLoS One, 12,
e0172684, https://doi.org/10.1371/journal.pone.0172684, 2017.
Moe-Byrne, T., Wagner, J. V., and McGuire, W.: Glutamine supplementation to
prevent morbidity and mortality in preterm infants, Cochrane Db.
Syst. Rev., Cd001457, https://doi.org/10.1002/14651858.CD001457.pub4, 2012.
Mongioi, L., Calogero, A. E., Vicari, E., Condorelli, R. A., Russo, G. I.,
Privitera, S., Morgia, G., and La Vignera, S.: The role of carnitine in male
infertility, Andrology, 4, 800–807, 10.1111/andr.12191, 2016.
Nguyen, P., Greene, E., Ishola, P., Huff, G., Donoghue, A., Bottje, W., and
Dridi, S.: Chronic Mild Cold Conditioning Modulates the Expression of
Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and
Improves Growth Performances in Young Chicks, PLoS One, 10, e0142319,
https://doi.org/10.1371/journal.pone.0142319, 2015.
Nordio, M.: A novel treatment for subclinical hyperthyroidism: a pilot study
on the beneficial effects of l-carnitine and selenium, Eur. Rev.
Med. Pharmaco., 21, 2268–2273, 2017.
Oh, M. H., Sun, I. H., Zhao, L., Leone, R. D., Sun, I. M., Xu, W., Collins,
S. L., Tam, A. J., Blosser, R. L., Patel, C. H., Englert, J. M., Arwood, M.
L., Wen, J., Chan-Li, Y., Tenora, L., Majer, P., Rais, R., Slusher, B. S.,
Horton, M. R., and Powell, J. D.: Targeting glutamine metabolism enhances
tumor-specific immunity by modulating suppressive myeloid cells, J.
Clin. Invest., 130, 3865–3884, https://doi.org/10.1172/jci131859, 2020.
Quinteiro-Filho, W. M., Rodrigues, M. V., Ribeiro, A., Ferraz-de-Paula, V.,
Pinheiro, M. L., Sá, L. R., Ferreira, A. J., and Palermo-Neto, J.: Acute
heat stress impairs performance parameters and induces mild intestinal
enteritis in broiler chickens: role of acute hypothalamic-pituitary-adrenal
axis activation, J. Anim. Sci., 90, 1986–1994, 10.2527/jas.2011-3949, 2012.
Ralph, C. R., Hemsworth, P. H., Leury, B. J., and Tilbrook, A. J.:
Relationship between plasma and tissue corticosterone in laying hens (Gallus
gallus domesticus): implications for stress physiology and animal welfare,
Domest. Anim. Endocrin., 50, 72–82, https://doi.org/10.1016/j.domaniend.2014.09.002,
2015.
Rehman, Z. U., Chand, N., and Khan, R. U.: The effect of vitamin E,
L-carnitine, and ginger on production traits, immune response, and
antioxidant status in two broiler strains exposed to chronic heat stress,
Environmental science and pollution research international, 24, 26851–26857, https://doi.org/10.1007/s11356-017-0304-8, 2017.
Ringseis, R., Keller, J., and Eder, K.: Mechanisms underlying the
anti-wasting effect of L-carnitine supplementation under pathologic
conditions: evidence from experimental and clinical studies, European
journal of nutrition, 52, 1421–1442, https://doi.org/10.1007/s00394-013-0511-0, 2013.
Roth, E.: Nonnutritive effects of glutamine, J. Nutr., 138,
2025–2031, https://doi.org/10.1093/jn/138.10.2025S, 2008.
Shi, H., Yao, R., Lian, S., Liu, P., Liu, Y., Yang, Y. Y., Yang, H., and Li,
S.: Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in
mouse liver in response to acute cold exposure, Stress (Amsterdam,
Netherlands), 22, 366–376, https://doi.org/10.1080/10253890.2019.1568987, 2019.
Solianik, R., Skurvydas, A., Urboniene, D., Eimantas, N., Daniuseviciute,
L., and Brazaitis, M.: Similar cold stress induces sex-specific
neuroendocrine and working memory responses, Cryo Letters, 36, 120–127,
2015.
Stehle, P. and Kuhn, K. S.: Glutamine: an obligatory parenteral nutrition
substrate in critical care therapy, BioMed Res. Int., 2015,
545467, https://doi.org/10.1155/2015/545467, 2015.
Tian, Y., Du, W., Cao, S., Wu, Y., Dong, N., Wang, Y., and Xu, Y.:
Systematic analyses of glutamine and glutamate metabolisms across different
cancer types, Chin. J. Cancer, 36, 88, https://doi.org/10.1186/s40880-017-0255-y,
2017.
Tsiouris, V., Georgopoulou, I., Batzios, C., Pappaioannou, N., Ducatelle,
R., and Fortomaris, P.: The effect of cold stress on the pathogenesis of
necrotic enteritis in broiler chicks, Avian Pathol., 44, 430–435, https://doi.org/10.1080/03079457.2015.1083094, 2015.
Viveros, A., Brenes, A., Arija, I., and Centeno, C.: Effects of microbial
phytase supplementation on mineral utilization and serum enzyme activities
in broiler chicks fed different levels of phosphorus, Poultry Sci., 81,
1172–1183, https://doi.org/10.1093/ps/81.8.1172, 2002.
Weinert, C. H., Empl, M. T., Krüger, R., Frommherz, L., Egert, B.,
Steinberg, P., and Kulling, S. E.: The influence of a chronic L-carnitine
administration on the plasma metabolome of male Fischer 344 rats, Mol.
Nutr. Food Res., 61, 1600651, https://doi.org/10.1002/mnfr.201600651, 2017.
Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M., Ryczko, M., Dennis, J.
W., Rabinowitz, J. D., Coller, H. A., and Thompson, C. B.: The hexosamine
biosynthetic pathway couples growth factor-induced glutamine uptake to
glucose metabolism, Gene. Dev., 24, 2784–2799,
https://doi.org/10.1101/gad.1985910, 2010.
Xi, P., Jiang, Z., Zheng, C., Lin, Y., and Wu, G.: Regulation of protein
metabolism by glutamine: implications for nutrition and health, Front.
Biosci., 16, 578–597, https://doi.org/10.2741/3707, 2011.
Yao, R., Yang, Y., Lian, S., Shi, H., Liu, P., Liu, Y., Yang, H., and Li,
S.: Effects of Acute Cold Stress on Liver O-GlcNAcylation and
Glycometabolism in Mice, Int. J. Mol. Sci., 19, 2815, https://doi.org/10.3390/ijms19092815, 2018.
Yaribeygi, H., Panahi, Y., Sahraei, H., Johnston, T. P., and Sahebkar, A.:
The impact of stress on body function: A review, EXCLI J., 16,
1057–1072, https://doi.org/10.17179/excli2017-480, 2017.
Yi, G. F., Allee, G. L., Knight, C. D., and Dibner, J. J.: Impact of
glutamine and Oasis hatchling supplement on growth performance, small
intestinal morphology, and immune response of broilers vaccinated and
challenged with Eimeria maxima, Poultry Sci., 84, 283–293, https://doi.org/10.1093/ps/84.2.283, 2005.
Yuan, L., Lin, H., Jiang, K. J., Jiao, H. C., and Song, Z. G.:
Corticosterone administration and high-energy feed results in enhanced fat
accumulation and insulin resistance in broiler chickens, Brit. Poultry
Sci., 49, 487–495, https://doi.org/10.1080/00071660802251731, 2008.
Zhang, W., Niu, C., Jia, H., and Chen, X.: Effects of acute cold exposure on
oxidative balance and total antioxidant capacity in juvenile Chinese
soft-shelled turtle, Pelodiscus sinensis, Integr. Zool., 12, 371–378,
https://doi.org/10.1111/1749-4877.12247, 2017.
Zhang, Z. W., Bi, M. Y., Yao, H. D., Fu, J., Li, S., and Xu, S. W.: Effect
of cold stress on expression of AMPKalpha-PPARalpha pathway and inflammation
genes, Avian Dis., 58, 415–426, https://doi.org/10.1637/10763-010814-Reg.1, 2014.
Zhao, J. P., Lin, H., Jiao, H. C., and Song, Z. G.: Corticosterone
suppresses insulin- and NO-stimulated muscle glucose uptake in broiler
chickens (Gallus gallus domesticus), Comparative biochemistry and
physiology, Toxicology & pharmacology, 149, 448–454, https://doi.org/10.1016/j.cbpc.2008.10.106, 2009.
Zuhl, M., Dokladny, K., Mermier, C., Schneider, S., Salgado, R., and
Moseley, P.: The effects of acute oral glutamine supplementation on
exercise-induced gastrointestinal permeability and heat shock protein
expression in peripheral blood mononuclear cells, Cell Stress
Chaperon., 20, 85–93, https://doi.org/10.1007/s12192-014-0528-1, 2015.
Short summary
The purpose of our study was to investigate whether glutamine and L-carnitine could be used as anti-cold stress nutrients to alleviate the adverse effects of cold stress on newborn broilers. Broilers were respectively fed with different levels of glutamine and L-carnitine according to the L16 (45) orthogonal experimental design for 3 weeks. Their interaction occurred and improved the growth performance, nutritional status and cold stress response of broilers at low temperature.
The purpose of our study was to investigate whether glutamine and L-carnitine could be used as...
