Articles | Volume 64, issue 1
Arch. Anim. Breed., 64, 17–25, 2021
https://doi.org/10.5194/aab-64-17-2021
Arch. Anim. Breed., 64, 17–25, 2021
https://doi.org/10.5194/aab-64-17-2021

Original study 18 Jan 2021

Original study | 18 Jan 2021

MiR-25-3p regulates the differentiation of intramuscular preadipocytes in goat via targeting KLF4

Yu Du et al.

Related subject area

Subject: DNA markers and gene expressions | Animal: Goats
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Cited articles

Acharya, A., Berry, D. C., Zhang, H., Jiang, Y., Jones, B. T., Hammer, R. E., Graff, J. M., and Mendell, J. T.: MiR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19, Gene. Dev., 33, 1367–1380, https://doi.org/10.1101/gad.328955.119, 2019. 
Anna, E., Shannon, H. C., Hillary J. C., Melissa, F., Noyan, G., and Katya, R.: An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis, J. Biol. Chem., 289, 21071–21081, https://doi.org/10.1074/jbc.M114.566406, 2014. 
Chen, T., Cui, J., Ma, L., Zeng, Y., and Chen, W.: The Effect of MicroRNA-331-3p on Preadipocytes Proliferation and Differentiation and Fatty Acid Accumulation in Laiwu Pigs, Biomed. Res. Int., 2019, 9287804, https://doi.org/10.1155/2019/9287804, 2019. 
Cui, J., Chen, W., Liu, J., Xu, T., and Zeng, Y.: Study on quantitative expression of PPARγ and ADRP in muscle and its association with intramuscular fat deposition of pig, SpringerPlus, 5, 1501, https://doi.org/10.1186/s40064-016-3187-0, 2016. 
Edwards, P. A., Tabor, D., Kast, H. R., and Venkateswaran, A.: Regulation of gene expression by SREBP and SCAP, Biochim Biophys Acta, 1529, 103–113, https://doi.org/10.1016/s1388-1981(00)00140-2, 2000. 
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Short summary
Intramuscular fat is a type of fatty tissue deposited between skeletal muscle fibers and muscle bundles, which is regulated by the number and size of preadipocytes in the muscle, and it is a key factor affecting meat tenderness and juiciness. As a member of miRNAs, a variety of studies suggested that miR-25-3p may play an important role in regulating lipid metabolism and adipocyte differentiation. This study attempts to investigate the role of miR-25-3p in goat intramuscular preadipocytes.