Articles | Volume 63, issue 2
Arch. Anim. Breed., 63, 461–470, 2020
https://doi.org/10.5194/aab-63-461-2020
Arch. Anim. Breed., 63, 461–470, 2020
https://doi.org/10.5194/aab-63-461-2020

Original study 10 Dec 2020

Original study | 10 Dec 2020

EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes

Zhihong Wu et al.

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Cited articles

Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., and Perrimon, N.: Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways, Genes. Dev., 12, 2610–2622, https://doi.org/10.1101/gad.12.16.2610, 1998. 
Cao, H., Jheon, A., Li, X., Sun, Z., Wang, J., Florez, S., Zhang, Z., McManus, M, T., Klein, O, D., and Amendt, B, A.: The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation, Development, 140, 3348–3359, https://doi.org/10.1242/dev.089193, 2013. 
Collu, G. M., Hidalgo-Sastre, A., and Brennan, K.: Wnt-Notch signalling crosstalk in development and disease, Cell. Mol. Life. Sci., 71, 3553–3567, https://doi.org/10.1007/s00018-014-1644-x, 2014. 
Działo, E., Tkacz, K., and Błyszczuk, P.: Crosstalk between the TGF-β and WNT signalling pathways during cardiac fibrogenesis, Acta. Biochim. Pol., 65, 341–349, https://doi.org/10.18388/abp.2018-2635, 2018. 
Fan, J., Park, H., Tan, S., and Lee, M.: Enhanced osteogenesis of adipose derived stem cells with Noggin suppression and delivery of BMP-2, PLoS ONE, 8, e72474, https://doi.org/10.1371/journal.pone.0072474, 2013. 
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Short summary
This study provided a theoretical and experimental basis for further studying the molecular regulation mechanism of hair follicle development. EDA and EDAR were both expressed in the skin tissue in the seven cashmere goat embryo stages. Moreover, EDA and EDAR play an important role in the formation of embryonic placode (Pc). After interfering with EDA and EDAR, the expression of BMP2, BMP4, noggin, β-catenin, TGF-β2, Wnt-10b, and NOTCH1 in fibroblasts and epithelial cells changed significantly.