Articles | Volume 62, issue 2
Arch. Anim. Breed., 62, 375–382, 2019
Arch. Anim. Breed., 62, 375–382, 2019

Original study 03 Jul 2019

Original study | 03 Jul 2019

DNA methylation of the PLIN1 promoter downregulates expression in chicken lines

Yuhang Sun et al.

Related subject area

Subject: DNA markers and gene expressions | Animal: Birds
Polymorphism analysis and expression patterns of the IGF1 gene in the Shitou goose
Jun Tang, Mao Guo, Jing Fu, Hongjia Ouyang, Yunbo Tian, Xu Shen, and Yunmao Huang
Arch. Anim. Breed., 64, 315–323,,, 2021
Short summary
The anti-Müllerian hormone gene's second exon is associated with the reproductive performance of Jinghai Yellow chickens
Yulin Wu, Manman Shen, Xuemei Yin, Yanjun Duan, Shanshan Zhang, Hao Ding, Lan Chen, Tao Zhang, Genxi Zhang, and Jinyu Wang
Arch. Anim. Breed., 64, 45–52,,, 2021
Genomic analysis of GBS data reveals genes associated with facial pigmentation in Xinyang blue-shelled layers
Haobin Hou, Xiaoliang Wang, Caiyun Zhang, Yingying Tu, Wenwei Lv, Xia Cai, Zhigang Xu, Junfeng Yao, and Changsuo Yang
Arch. Anim. Breed., 63, 483–491,,, 2020
Comparative transcriptome and histomorphology analysis of testis tissues from mulard and Pekin ducks
Li Li, Linli Zhang, Zhenghong Zhang, Nemat O. Keyhani, Qingwu Xin, Zhongwei Miao, Zhiming Zhu, Zhengchao Wang, Junzhi Qiu, and Nenzhu Zheng
Arch. Anim. Breed., 63, 303–313,,, 2020
Short summary
RAI14 in the blood feather regulates chicken pigmentation
Adeyinka Abiola Adetula, Xiaolei Liu, Liubin Yang, Chengchi Fang, Hui Yu, Hua Li, and Shijun Li
Arch. Anim. Breed., 63, 231–239,,, 2020

Cited articles

Bialesova, L., Kulyte, A., Petrus, P., Sinha, I., Laurencikiene, J., Zhao, C., Wright, K. D., Arner, P., and Dahlman, I.: Epigenetic regulation of PLIN 1 in obese women and its relation to lipolysis, Sci. Rep., 7, 10152,, 2017. 
Birsoy, K., Chen, Z., and Friedman, J.: Transcriptional regulation of adipogenesis by KLF4, Cell Metab., 7, 339–347,, 2008. 
Bowers, R. R., Kim, J. W., Otto, T. C., and Lane, M. D.: Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene, P. Natl. Acad. Sci. USA, 103, 13022–13027,, 2006. 
Campanero, M. R., Armstrong, M. I., and Flemington, E. K.: CpG methylation as a mechanism for the regulation of E2F activity, P. Natl. Acad. Sci. USA, 97, 6481–6486,, 2000. 
Castro-Chavez, F., Yechoor, V. K., Saha, P. K., Martinez-Botas, J., Wooten, E. C., Sharma, S., O'Connell, P., Taegtmeyer, H., and Chan, L.: Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile, Diabetes., 52, 2666–2674, 2003. 
Short summary
To study whether chicken PLIN1 expression is regulated by DNA methylation, we analyzed the promoter methylation status and expression of the PLIN1 gene, and found that chicken PLIN1 expression was significantly positively correlated with abdominal fat percentage, the DNA methylation of CpG5 at position −490 bp of the promoter had a certain impact on PLIN1 expression. These results imply that epigenetic regulation of PLIN1 might be important for hypertrophic growth in chicken adipose development.