Articles | Volume 62, issue 2
Arch. Anim. Breed., 62, 375–382, 2019
https://doi.org/10.5194/aab-62-375-2019
Arch. Anim. Breed., 62, 375–382, 2019
https://doi.org/10.5194/aab-62-375-2019

Original study 03 Jul 2019

Original study | 03 Jul 2019

DNA methylation of the PLIN1 promoter downregulates expression in chicken lines

Yuhang Sun et al.

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Subject: DNA markers and gene expressions | Animal: Birds
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Cited articles

Bialesova, L., Kulyte, A., Petrus, P., Sinha, I., Laurencikiene, J., Zhao, C., Wright, K. D., Arner, P., and Dahlman, I.: Epigenetic regulation of PLIN 1 in obese women and its relation to lipolysis, Sci. Rep., 7, 10152, https://doi.org/10.1038/s41598-017-09232-y, 2017. 
Birsoy, K., Chen, Z., and Friedman, J.: Transcriptional regulation of adipogenesis by KLF4, Cell Metab., 7, 339–347, https://doi.org/10.1016/j.cmet.2008.02.001, 2008. 
Bowers, R. R., Kim, J. W., Otto, T. C., and Lane, M. D.: Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene, P. Natl. Acad. Sci. USA, 103, 13022–13027, https://doi.org/10.1073/pnas.0605789103, 2006. 
Campanero, M. R., Armstrong, M. I., and Flemington, E. K.: CpG methylation as a mechanism for the regulation of E2F activity, P. Natl. Acad. Sci. USA, 97, 6481–6486, https://doi.org/10.1073/pnas.100340697, 2000. 
Castro-Chavez, F., Yechoor, V. K., Saha, P. K., Martinez-Botas, J., Wooten, E. C., Sharma, S., O'Connell, P., Taegtmeyer, H., and Chan, L.: Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile, Diabetes., 52, 2666–2674, 2003. 
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Short summary
To study whether chicken PLIN1 expression is regulated by DNA methylation, we analyzed the promoter methylation status and expression of the PLIN1 gene, and found that chicken PLIN1 expression was significantly positively correlated with abdominal fat percentage, the DNA methylation of CpG5 at position −490 bp of the promoter had a certain impact on PLIN1 expression. These results imply that epigenetic regulation of PLIN1 might be important for hypertrophic growth in chicken adipose development.