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Articles | Volume 62, issue 2
Articles | Volume 62, issue 2
https://doi.org/10.5194/aab-62-375-2019
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-62-375-2019
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 62, issue 2
Original study
 | 
03 Jul 2019
Original study |  | 03 Jul 2019

DNA methylation of the PLIN1 promoter downregulates expression in chicken lines

Yuhang Sun, Rui Li, Guiying Zhai, Xinyang Zhang, and Yuxiang Wang

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Short summary
To study whether chicken PLIN1 expression is regulated by DNA methylation, we analyzed the promoter methylation status and expression of the PLIN1 gene, and found that chicken PLIN1 expression was significantly positively correlated with abdominal fat percentage, the DNA methylation of CpG5 at position −490 bp of the promoter had a certain impact on PLIN1 expression. These results imply that epigenetic regulation of PLIN1 might be important for hypertrophic growth in chicken adipose development.
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