Articles | Volume 61, issue 3
Arch. Anim. Breed., 61, 271–278, 2018
Arch. Anim. Breed., 61, 271–278, 2018

Original study 11 Jul 2018

Original study | 11 Jul 2018

The microRNA gene bta-mir-2313 in cattle: an atlas of regulatory elements and an association analysis with growth and carcass traits in the Slovenian Simental cattle breed

Špela Malovrh et al.

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Cited articles

Agarwal, V., Bell, G. W., Nam, J. W., and Bartel, D. P.: Predicting effective microRNA target sites in mammalian mRNAs, Elife, 4, e05005,, 2015. 
Bartel, D. P.: MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281–297, 2004. 
Gao, Q., Ju, Z., Zhang, Y., Huang, J., Zhang, X., Qi, C., Li, J., Zhong, J., Li, G., and Wang, C.: Association of TNP2 gene polymorphisms of the bta-miR-154 target site with the semen quality traits of Chinese Holstein bulls, PLoS One, 9, e84355,, 2014. 
Georges, M., Coppieters, W., and Charlier, C.: Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease, Curr. Opin. Genet. Dev., 17, 166–176,, 2007. 
Short summary
Effects of miRNA polymorphisms on phenotypic traits have been studied in several species but much less in cattle. We tested the association between polymorphisms of bta-miR-2313 and growth and carcass traits in the Slovenian Simmental cattle breed and developed an atlas of miRNA regulatory elements. Bta-miR-2313 warrants further functional analysis since it overlaps with several QTL, has over 3100 predicted targets, and is located within GRAMD1B, associated with production traits in cattle.