Articles | Volume 59, issue 3
Arch. Anim. Breed., 59, 351–361, 2016
Arch. Anim. Breed., 59, 351–361, 2016

Original study 11 Aug 2016

Original study | 11 Aug 2016

Exploration of the exonic variations of the iPSC-related Nanog gene and their effects on phenotypic traits in cattle

Meng Zhang et al.

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Cited articles

Andersson, O., Korach-Andre, M., Reissmann, E., Ibáñez, C. F., and Bertolino, P.: Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity, P. Natl. Acad. Sci. USA, 105, 7252–7256, 2008.
Bali, V. and Bebok, Z.: Decoding mechanisms by which silent codon changes influence protein biogenesis and function, Int. J. Biochem. Cell B., 64, 58–74, 2015.
Cervantes-Camacho, C., Beltrán-Langarica, A., Ochoa-Uribe, A. K., Marsch-Moreno, M., Ayala-Sumuano, J. T., Velez-delValle, C., and Kuri-Harcuch, W.: The transient expression of Klf4 and Klf5 during adipogenesis depends on GSK3β activity, Adipocyte, 4, 248–255, 2015.
Chen, R., Yu, S., Ren, F., Lv, X. Y., and Pan, C. Y.: Detection of one large insertion/deletion (indel) and two novel SNPs within the SPEF2 gene and their associations with male piglet reproduction traits, Arch. Anim. Breed., 59, 275–283,, 2016.
Clark, A. T., Rodriguez, R. T., Bodnar, M. S., Abeyta, M. J., Cedars, M. I., Turek, P. J., Firpo, M. T., and Reijo Pera, R. A.: Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma, Stem Cells, 22, 169–179, 2004.
Short summary
Nanog is an important pluripotent transcription regulator, and its overexpression leads to a high expression of the growth and differentiation factor 3, affecting animal growth traits. The aim of this study was to explore the genetic variations within the Nanog gene and their effects on phenotypic traits in cattle. Six novel exonic single nucleotide polymorphisms were found in six cattle breeds and indicated that Nanog could be a candidate gene for marker-assisted selection in cattle breeding.