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Articles | Volume 68, issue 4
Articles | Volume 68, issue 4
https://doi.org/10.5194/aab-68-703-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-68-703-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 68, issue 4
Original study
 | 
03 Dec 2025
Original study |  | 03 Dec 2025

Molecular characterization and functional analysis of buffalo prolactin (PRL) in mammary gland development and lactation

Lige Huang, Xinyang Fan, Xiaohong Teng, Lindong Qian, Zhipeng Bao, and Yongwang Miao

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Short summary
This study finds that the buffalo prolactin (PRL) gene is structurally similar to that of other Bovidae species and is highly active in the lactating mammary gland. In buffalo mammary epithelial cells (BuMECs), increased PRL stimulated cell proliferation and milk production by activating signaling pathways (Janus kinase 2/signal transducer and activator of transcription 5, mammalian target of papamycin, and mitogen-activated protein kinase). This research provides a basis for improving buffalo milk yield. 
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