Articles | Volume 67, issue 3
https://doi.org/10.5194/aab-67-361-2024
https://doi.org/10.5194/aab-67-361-2024
Original study
 | 
17 Jul 2024
Original study |  | 17 Jul 2024

N-acetylcysteine may improve endometrial receptivity by modulating endometrial stromal cells in goats

Kaibin Fu, Xiang Chen, Xingzhou Tian, Wen Tang, Ting Gong, Yan Zhang, and Taotao Ji

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Cited articles

Achache, H., Tsafrir, A., Prus, D., Reich, R., and Revel, A.: Defective endometrial prostaglandin synthesis identified in patients with repeated implantation failure undergoing in vitro fertilization, Fertil. Steril., 94, 1271–1278, https://doi.org/10.1016/j.fertnstert.2009.07.1668, 2010. 
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Aldini, G., Altomare, A., Baron, G., Vistoli, G., Carini, M., Borsani, L., and Sergio, F.: N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why, Free Radic. Res., 52, 751–762, https://doi.org/10.1080/10715762.2018.1468564, 2018. 
Aljaser, F. S., Ghneim, H. K., ALshubaily, M. M., Abudawood, M., Almajed, F., Fatima, S., and ALsheikh, Y. A.: Glutathione and oxidized nicotinamide adenine dinucleotide (NAD (+)) redox status in plasma and placental tissue of Saudi patients with intrauterine growth restriction, Saudi. Med. J., 42, 491–498, https://doi.org/10.15537/smj.2021.42.5.20200685, 2021. 
Barrozo, L. G., Paulino, L., Silva, B. R., Barbalho, E. C., Nascimento, D. R., Neto, M., and Silva, J.: N-acetyl-cysteine and the control of oxidative stress during in vitro ovarian follicle growth, oocyte maturation, embryo development and cryopreservation, Anim. Reprod. Sci., 231, 106801, https://doi.org/10.1016/j.anireprosci.2021.106801, 2021. 
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Short summary
We used endometrial stromal cells of Qianbei Ma goats as our study subjects and found that N-acetylcysteine could promote the proliferation of endometrial stromal cells and increase the viability, antioxidant activity, mitochondrial membrane potential and expression of endometrial receptivity marker genes of endometrial stromal cells, which suggests that N-acetylcysteine may be beneficial in improving endometrial receptivity of goats.