Articles | Volume 66, issue 1
https://doi.org/10.5194/aab-66-93-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-66-93-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original study
| 
27 Feb 2023
Original study |
| 27 Feb 2023
| 27 Feb 2023
The role of miR-369-3p in proliferation and differentiation of preadipocytes in Aohan fine-wool sheep
Shijie Xue
College of Animal Science and Technology, Qingdao Agricultural
University, Qingdao 266109, China
Kaidong Liu
Qingdao animal husbandry and veterinary research Institute, Qingdao
266032, China
Le Zhao
College of Animal Science and Technology, Qingdao Agricultural
University, Qingdao 266109, China
Lisheng Zhou
College of Animal Science and Technology, Qingdao Agricultural
University, Qingdao 266109, China
Xiaoxiao Gao
College of Animal Science and Technology, Qingdao Agricultural
University, Qingdao 266109, China
Lirong Liu
China Animal Health and Epidemiology Center, Qingdao 266032, China
Nan Liu
CORRESPONDING AUTHOR
College of Animal Science and Technology, Qingdao Agricultural
University, Qingdao 266109, China
Jianning He
CORRESPONDING AUTHOR
College of Animal Science and Technology, Qingdao Agricultural
University, Qingdao 266109, China
Related authors
No articles found.
Yu Cui, Chunliang Wang, Lirong Liu, Nan Liu, and Jianning He
Arch. Anim. Breed., 65, 11–19, https://doi.org/10.5194/aab-65-11-2022, https://doi.org/10.5194/aab-65-11-2022, 2022
Short summary
Short summary
Here we clarify the specific expression and mechanism of the EPH receptor and Ephrin during the development of hair follicles, as well as their upstream and downstream signaling pathways and activation pathways. This study verified the effect of EPHA4 and Ephrin A3 genes on fine-hair follicles through RT-qPCR and immunohistochemistry testing. It is of great significance as it could speed up the promotion of breeding sheep for wool.
Related subject area
Subject: Husbandry | Animal: Sheep
Prediction of reproductive performance of ewes based on the early production data, ewe birth rank, dam age, and dam birth rank
Selection signature analysis reveals RDH5 performed key function in vision during sheep domestication process
Effect of oxytocin added into sperm on artificial insemination in sheep
Screening of three-way crossbred combination and genetic effect analysis of the SNP in the CLPG gene in meat sheep
The effect of different management systems on milk yield and milk quality in Awassi sheep
Fatty acid profile and sensory properties of lamb meat from males of five indigenous breeds
The comparative results of myostatin introgression from donor Texel to recipient Ramlıç sheep with the aspects of growth, pre-, and post-slaughter carcass traits in the second backcross generation
The effects of restrictive measures due to the COVID-19 pandemic on the extensive farming system of small ruminants
Expression and distribution of EPHA4 and Ephrin A3 in Aohan fine-wool sheep skin
Single-nucleotide polymorphisms in FLT3, NLRP5, and TGIF1 are associated with litter size in Small-tailed Han sheep
Determining the factors affecting the gestational length in sheep
Effects of genotype and fattening system on the quality of male lamb meat – Part 1: Technological properties and carcass measurements
Fatty acids in intramuscular fat of Ile de France lambs in two different production systems
Body condition status at mating affects gestation length, offspring yield and return rate in ewes
Analysis of multivariate relations among birth weight, survivability traits, growth performance, and some important factors in Suffolk lambs
The ovulation rate, plasma progesterone and estradiol concentration, and litter size of a local ewe breed kept in a barn vs. those kept under an overhead shelter
The effect of ewe body condition at lambing on growth of lambs and colostral specific gravity
Meta-analysis of intramuscular fatty acid composition of Mediterranean lambs
Effects of ewe live weight and age on reproductive performance, lamb growth, and survival in Central Anatolian Merino sheep
Characteristics and typology of sheep herding systems in the suburban area of Ouagadougou (Burkina Faso)
Performance of electronic and visual ear tags in lambs under extensive conditions in Turkey
Ivan Vlahek, Velimir Sušić, Anamaria Ekert Kabalin, Sven Menčik, Maja Maurić Maljković, Aneta Piplica, Juraj Šavorić, and Siniša Faraguna
Arch. Anim. Breed., 66, 145–151, https://doi.org/10.5194/aab-66-145-2023, https://doi.org/10.5194/aab-66-145-2023, 2023
Short summary
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Ewes' reproductive performance could be predicted using the data available early in their life. Ewe birth rank, dam birth rank, first litter size, and first lambing interval are significantly associated with ewe reproductive performance up to the fourth year of life. Precise prediction of ewe reproductive performance using the early predictors is impossible due to the low R2 predicted. The value of the lower threshold of the 95 % prediction interval might be useful in making selection decisions.
Ruixue Hu, Xunping Jiang, Huiguo Yang, and Guiqiong Liu
Arch. Anim. Breed., 66, 81–91, https://doi.org/10.5194/aab-66-81-2023, https://doi.org/10.5194/aab-66-81-2023, 2023
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Genes enriched in sensory perception were positively selected via selection signature analysis between wild Asiatic mouflon and domesticated Hu sheep. Among them, RDH5 is one of the key enzymes in the synthesis of retinoic acid (RA), which is related to human retinopathy. The c.722T>C/p.M241T mutation of RDH5 affects retinol dehydrogenase activity in the domestication process of sheep.
Çağrı Kandemir
Arch. Anim. Breed., 66, 61–69, https://doi.org/10.5194/aab-66-61-2023, https://doi.org/10.5194/aab-66-61-2023, 2023
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This study aimed to understand the effects of adding low-dose oxytocin hormone into ram semen on the pregnancy rate and reproductive efficiency of sheep. A total of 53 out of 122 Chios ewes were inseminated with oxytocin hormone content, and successful pregnancy was achieved 90.56 % of them. In examination of the pregnancy rate, one of the indicators of reproductive performance, the difference between the groups is statistically significant (p = 0.046; p ≤ 0.05).
Jian Tao Wang, Guo Sen Wang, Yuan Fang Gong, Xian Qiao, Xiang Li, Gui Zhu Wang, Ying Zhen Zheng, Jian Guo Lv, Xiang Long Li, and Zheng Zhu Liu
Arch. Anim. Breed., 65, 417–426, https://doi.org/10.5194/aab-65-417-2022, https://doi.org/10.5194/aab-65-417-2022, 2022
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Three-way crossbreeding was performed with Australian White, Dorper, and Charollais as terminal male parents and elite F1 hybrids of Australian × Han, Dorper × Han, and Charollais × Han as female parents. Based on the growth of three-way crossbred and Small-tailed Han lambs as well as the effects of CLPG, the offspring of male Australian White and female Charollais × Han showed apparent heterosis, and the individuals with the T allele had improved body weight and body size.
Ayhan Ceyhan, Mustafa Avcı, Mehmet Mustafa Tanrıkulu, Beyza Yılmaz, and Mubeen Ul Hassan
Arch. Anim. Breed., 65, 407–416, https://doi.org/10.5194/aab-65-407-2022, https://doi.org/10.5194/aab-65-407-2022, 2022
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This study aimed to evaluate the effect of concentrate-based feeding (CF) and artificial pasture-based grazing (APG) management systems on milk yield, fatty acid, nutritional indices, and milk physicochemical characteristics of Awassi ewes.
Levent Mercan, Mehmet A. Cam, Mustafa Olfaz, Koray Kirikci, Hacer Tufekci, and Unal Kilic
Arch. Anim. Breed., 65, 341–352, https://doi.org/10.5194/aab-65-341-2022, https://doi.org/10.5194/aab-65-341-2022, 2022
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This article investigated the lamb meat physical, chemical, instrumental, and sensory quality characteristics of 60 meat samples from five indigenous sheep breeds. As meat quality is vital in healthy and balanced nutrition, the presented results will benefit consumers, nutritionists, and those working in this field.
Mustafa Tekerli, Metin Erdoğan, Serdar Koçak, Koray Çelikeloğlu, Ebubekir Yazıcı, Özlem Hacan, Zehra Bozkurt, Mustafa Demirtaş, and Samet Çinkaya
Arch. Anim. Breed., 65, 231–238, https://doi.org/10.5194/aab-65-231-2022, https://doi.org/10.5194/aab-65-231-2022, 2022
Short summary
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Factors such as genotype, sex, type of birth, maternal age, weaning age and birth weight must be considered in evaluation of pre- and post-weaning growth traits. Myostatin mutation was introduced to native Turkish breed Ramlıç by marker-assisted introgression (MAI). The mutation has a positive effect on ultrasonographic carcass traits in crosses. Lambs with myostatin tended to have deeper longissimus muscle and good carcass characteristics, and they may be recommendable for Turkish farmers.
Maria D. Yiakoulaki, Eleni T. Tsiobani, Christina-Ioanna G. Galliou, and Konstantinos G. Papaspyropoulos
Arch. Anim. Breed., 65, 157–169, https://doi.org/10.5194/aab-65-157-2022, https://doi.org/10.5194/aab-65-157-2022, 2022
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We studied the impact of the COVID-19 restrictive measures on the extensive farming system of small ruminants. We found that the breeders’ daily work routine was negatively affected in holdings with a high number of sheep. The majority of breeders did not change the movements of the animals in pastures, the amount of the given feedstuffs, the hygienic conditions on the farms, or the employed workers. A decrease in demand for animal products and a decrease in their prices were observed.
Yu Cui, Chunliang Wang, Lirong Liu, Nan Liu, and Jianning He
Arch. Anim. Breed., 65, 11–19, https://doi.org/10.5194/aab-65-11-2022, https://doi.org/10.5194/aab-65-11-2022, 2022
Short summary
Short summary
Here we clarify the specific expression and mechanism of the EPH receptor and Ephrin during the development of hair follicles, as well as their upstream and downstream signaling pathways and activation pathways. This study verified the effect of EPHA4 and Ephrin A3 genes on fine-hair follicles through RT-qPCR and immunohistochemistry testing. It is of great significance as it could speed up the promotion of breeding sheep for wool.
Si Chen, Lin Tao, Xiaoyun He, Ran Di, Xiangyu Wang, and Mingxing Chu
Arch. Anim. Breed., 64, 475–486, https://doi.org/10.5194/aab-64-475-2021, https://doi.org/10.5194/aab-64-475-2021, 2021
Short summary
Hilal Tozlu Celik, Fatih Ahmet Aslan, Yeliz Kasko Arıcı, Metehan Eser Kahveci, and İbrahim Kiper
Arch. Anim. Breed., 64, 83–89, https://doi.org/10.5194/aab-64-83-2021, https://doi.org/10.5194/aab-64-83-2021, 2021
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This research aimed to determine the effects of body weight, the body condition score (BCS), body measurements, birth type, birth weight and sex on the gestational length in sheep. The lowest and highest gestational lengths were found to be 148.90 and 151.41 d respectively. It is thought that the use of the BCS, which is easily applied by the breeder, will have a positive effect on determining the bodily reserves of sheep and the reproductive efficiency as well as on obtaining healthy lambs.
Mehmet Sarı, Yüksel Aksoy, Kadir Önk, Hakan Erinç, Serpil A. Işık, and Muammer Tilki
Arch. Anim. Breed., 62, 605–614, https://doi.org/10.5194/aab-62-605-2019, https://doi.org/10.5194/aab-62-605-2019, 2019
Milan Margetín, Marta Oravcová, Jana Margetínová, and Róbert Kubinec
Arch. Anim. Breed., 61, 395–403, https://doi.org/10.5194/aab-61-395-2018, https://doi.org/10.5194/aab-61-395-2018, 2018
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Fatty acid composition in the intramuscular fat of the musculus longissimus dorsi of Ile de France purebred lambs in two production systems (lambs and ewes were assigned to pasture and fed without concentrates vs. lambs and ewes were assigned to a stable and fed with hay/silage and concentrates) was evaluated using gas chromatography. An analysis of variance was used for comparison. No such comparison had previously been carried out in Slovakia. Meat from lambs assigned to pasture was better.
Mehmet Akif Cam, Ali Vaiz Garipoglu, and Koray Kirikci
Arch. Anim. Breed., 61, 221–228, https://doi.org/10.5194/aab-61-221-2018, https://doi.org/10.5194/aab-61-221-2018, 2018
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In sheep production, the body condition scores and parities are important environmental factors affecting lamb yield. Extreme body condition scores (fattening state) lead to negative effects on lamb yield. In the present study, it was revealed that ewes with medium and fat body condition scores (BCS: 2.5–4.0) were profitable. It was shown that the body condition score had minimal effects on the birth weights of lambs, and the incidence of dystocia was increased in thin and very fat ewes.
Martin Ptáček, Jaromír Ducháček, Luděk Stádník, Josef Hakl, and Milena Fantová
Arch. Anim. Breed., 60, 43–50, https://doi.org/10.5194/aab-60-43-2017, https://doi.org/10.5194/aab-60-43-2017, 2017
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The aim of this study was to perform a multivariate analysis of lambs' birth weight, survivability traits, growth performance traits, and other defined factors. The study focused on one flock of Suffolk sheep kept under permanent pasture management. Overall 1012 lambs were investigated over 3 years. The results of the study detected lambs' optimal birth weight for this management system. This study also suggested practical implications of important factors when improving flock profitability.
Ewa Kuźnicka, Witold Rant, Aurelia Radzik-Rant, Małgorzata Kunowska-Slósarz, and Marek Balcerak
Arch. Anim. Breed., 59, 145–150, https://doi.org/10.5194/aab-59-145-2016, https://doi.org/10.5194/aab-59-145-2016, 2016
Ferda Karakuş and Metin Atmaca
Arch. Anim. Breed., 59, 107–112, https://doi.org/10.5194/aab-59-107-2016, https://doi.org/10.5194/aab-59-107-2016, 2016
A. Kaić, B. Mioč, A. Kasap, and K. Potočnik
Arch. Anim. Breed., 59, 1–8, https://doi.org/10.5194/aab-59-1-2016, https://doi.org/10.5194/aab-59-1-2016, 2016
A. H. Aktaş, Ş. Dursun, Ş. Doğan, Z. Kiyma, U. Demirci, and İ Halıcı
Arch. Anim. Breed., 58, 451–459, https://doi.org/10.5194/aab-58-451-2015, https://doi.org/10.5194/aab-58-451-2015, 2015
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We aimed to evaluate the effects of premating ewe weight and age on ewe reproductive performance and lamb growth and survival in Central Anatolian Merino sheep. Multiple birth rate, birth weight, and growth performance of the lambs increased proportionally with the increase in live weight of the ewes prior to mating. Therefore, it is important to increase the live weight of lambs at puberty and to select ewes that attain a higher premating weight for breeding.
K. Tindano, N. Moula, A. Traoré, P. Leroy, and N. Antoine-Moussiaux
Arch. Anim. Breed., 58, 415–423, https://doi.org/10.5194/aab-58-415-2015, https://doi.org/10.5194/aab-58-415-2015, 2015
F. Karakus, A. Ö. Demir, S. Akkol, A. Düzgün, and M. Karakus
Arch. Anim. Breed., 58, 287–292, https://doi.org/10.5194/aab-58-287-2015, https://doi.org/10.5194/aab-58-287-2015, 2015
Cited articles
An, H. X., Beckmann, M. W., Reifenberger, G., Bender, H. G., and
Niederacher, D.: Gene amplification and overexpression of CDK4 in sporadic
breast carcinomas is associated with high tumor cell proliferation, Am. J.
Pathol., 154, 113–118, https://doi.org/10.1016/s0002-9440(10)65257-1, 1999.
Arner, P. and Kulyté, A.: MicroRNA regulatory networks in human adipose
tissue and obesity, Nat. Rev. Endocrinol., 11, 276–288,
https://doi.org/10.1038/nrendo.2015.25, 2015.
Azad, T., Tashakor, A., and Hosseinkhani, S.: Split-luciferase complementary
assay: applications, recent developments, and future perspectives, Anal.
Bioanal. Chem., 406, 5541–5560, https://doi.org/10.1007/s00216-014-7980-8,
2014.
Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y. Z., Ruiz-Lozano, P., Chien,
K. R., Koder, A., and Evans, R. M.: PPAR gamma is required for placental,
cardiac, and adipose tissue development, Mol. Cell, 4, 585–595,
https://doi.org/10.1016/s1097-2765(00)80209-9, 1999.
Blanchet, E., Annicotte, J. S., Lagarrigue, S., Aguilar, V., Clapé, C.,
Chavey, C., Fritz, V., Casas, F., Apparailly, F., Auwerx, J., and Fajas, L.:
E2F transcription factor-1 regulates oxidative metabolism, Nat. Cell Biol.,
13, 1146–1152, https://doi.org/10.1038/ncb2309, 2011.
Cao, H., Zhang, S., Shan, S., Sun, C., Li, Y., Wang, H., Yu, S., Liu, Y.,
Guo, F., Zhai, Q., Wang, Y. C., Jiang, J., Wang, H., Yan, J., Liu, W., and
Ying, H.: Ligand-dependent corepressor (LCoR) represses the transcription
factor C/EBPβ during early adipocyte differentiation, J. Biol. Chem.,
292, 18973–18987, https://doi.org/10.1074/jbc.M117.793984, 2017.
Chen, C., Zong, Y., Tang, J., Ke, R., Lv, L., Wu, M., and Lu, J.: miR-369-3p
serves as prognostic factor and regulates cancer progression of
hepatocellular carcinoma, Per. Med., 18, 375–388,
https://doi.org/10.2217/pme-2020-0012, 2021.
Galleggiante, V., De Santis, S., Liso, M., Verna, G., Sommella, E.,
Mastronardi, M., Campiglia, P., Chieppa, M., and Serino, G.:
Quercetin-Induced miR-369-3p Suppresses Chronic Inflammatory Response
Targeting C/EBP-β, Mol. Nutr. Food Res., 63, e1801390,
https://doi.org/10.1002/mnfr.201801390, 2019.
Gao, H., Bo, Z., Wang, Q., Luo, L., Zhu, H., and Ren, Y.: Salvanic acid B
inhibits myocardial fibrosis through regulating TGF-β1/Smad signaling
pathway, Biomed. Pharmacother., 110, 685–691,
https://doi.org/10.1016/j.biopha.2018.11.098, 2019.
Guo, L., Li, X., and Tang, Q. Q.: Transcriptional regulation of adipocyte
differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP)
β, J. Biol. Chem., 290, 755–761,
https://doi.org/10.1074/jbc.R114.619957, 2015.
Han, F., Li, J., Zhao, R., Liu, L., Li, L., Li, Q., He, J., and Liu, N.:
Identification and co-expression analysis of long noncoding RNAs and mRNAs
involved in the deposition of intramuscular fat in Aohan fine-wool sheep,
BMC Genomics, 22, 98, https://doi.org/10.1186/s12864-021-07385-9, 2021a.
Han, F., Zhou, L., Zhao, L., Wang, L., Liu, L., Li, H., Qiu, J., He, J., and
Liu, N.: Identification of miRNA in Sheep Intramuscular Fat and the Role of
miR-193a-5p in Proliferation and Differentiation of 3T3-L1, Front. Genet.,
12, 633295, https://doi.org/10.3389/fgene.2021.633295, 2021b.
Hawkins, P., Prescott, M. J., Carbone, L., Dennison, N., Johnson, C.,
Makowska, I. J., Marquardt, N., Readman, G., Weary, D. M., and Golledge, H.
D.: A Good Death? Report of the Second Newcastle Meeting on Laboratory
Animal Euthanasia, Animals (Basel), 6, 50, https://doi.org/10.3390/ani6090050,
2016.
Hu, B., Zhang, Y., Deng, T., Gu, J., Liu, J., Yang, H., Xu, Y., Yan, Y.,
Yang, F., Zhang, H., Jin, Y., and Zhou, J.: PDPK1 regulates autophagosome
biogenesis by binding to PIK3C3, Autophagy, 17, 2166–2183,
https://doi.org/10.1080/15548627.2020.1817279, 2021.
Iorio, M. V., Ferracin, M., Liu, C. G., Veronese, A., Spizzo, R., Sabbioni,
S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., Ménard, S.,
Palazzo, J. P., Rosenberg, A., Musiani, P., Volinia, S., Nenci, I., Calin,
G. A., Querzoli, P., Negrini, M., and Croce, C. M.: MicroRNA gene expression
deregulation in human breast cancer, Cancer Res., 65, 7065–7070,
https://doi.org/10.1158/0008-5472.Can-05-1783, 2005.
Jia, W., Di, C., and Shi, L.: Applications of lipidomics in goat meat
products: Biomarkers, structure, nutrition interface and future
perspectives, J. Proteomics, 270, 104753,
https://doi.org/10.1016/j.jprot.2022.104753, 2023.
Karkeni, E., Astier, J., Tourniaire, F., El Abed, M., Romier, B., Gouranton,
E., Wan, L., Borel, P., Salles, J., Walrand, S., Ye, J., and Landrier, J.
F.: Obesity-associated Inflammation Induces microRNA-155 Expression in
Adipocytes and Adipose Tissue: Outcome on Adipocyte Function, J. Clin.
Endocr. Metab., 101, 1615–1626, https://doi.org/10.1210/jc.2015-3410,
2016.
Kim, H. J., Cho, H., Alexander, R., Patterson, H. C., Gu, M., Lo, K. A., Xu,
D., Goh, V. J., Nguyen, L. N., Chai, X., Huang, C. X., Kovalik, J. P.,
Ghosh, S., Trajkovski, M., Silver, D. L., Lodish, H., and Sun, L.: MicroRNAs
are required for the feature maintenance and differentiation of brown
adipocytes, Diabetes, 63, 4045–4056, https://doi.org/10.2337/db14-0466,
2014.
Kim, K. H. and Lee, M. S.: Autophagy – a key player in cellular and body
metabolism, Nat. Rev. Endocrinol., 10, 322–337,
https://doi.org/10.1038/nrendo.2014.35, 2014.
Krek, W. and Nigg, E. A.: Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites, Embo J., 10, 305–316, https://doi.org/10.1002/j.1460-2075.1991.tb07951.x, 1991.
Lagarrigue, S., Lopez-Mejia, I. C., Denechaud, P. D., Escoté, X.,
Castillo-Armengol, J., Jimenez, V., Chavey, C., Giralt, A., Lai, Q., Zhang,
L., Martinez-Carreres, L., Delacuisine, B., Annicotte, J. S., Blanchet, E.,
Huré, S., Abella, A., Tinahones, F. J., Vendrell, J., Dubus, P., Bosch,
F., Kahn, C. R., and Fajas, L.: CDK4 is an essential insulin effector in
adipocytes, J. Clin. Invest., 126, 335–348,
https://doi.org/10.1172/jci81480, 2016.
Li, B., Huang, X., Yang, C., Ge, T., Zhao, L., Zhang, X., Tian, L., and
Zhang, E.: miR-27a Regulates Sheep Adipocyte Differentiation by Targeting
CPT1B Gene, Animals (Basel), 12, 28, https://doi.org/10.3390/ani12010028, 2021.
Li, P., Dong, M., and Wang, Z.: Downregulation of TSPAN13 by miR-369-3p
inhibits cell proliferation in papillary thyroid cancer (PTC), Bosnian J.
Basic Med., 19, 146–154, https://doi.org/10.17305/bjbms.2018.2865,
2019.
Lie, S., Morrison, J. L., Williams-Wyss, O., Suter, C. M., Humphreys, D. T.,
Ozanne, S. E., Zhang, S., MacLaughlin, S. M., Kleemann, D. O., Walker, S.
K., Roberts, C. T., and McMillen, I. C.: Impact of maternal undernutrition
around the time of conception on factors regulating hepatic lipid metabolism
and microRNAs in singleton and twin fetuses, Am. J. Physiol. Endocrinol.
Metab., 310, E148–E159, https://doi.org/10.1152/ajpendo.00600.2014, 2016.
Linhart, H. G., Ishimura-Oka, K., DeMayo, F., Kibe, T., Repka, D.,
Poindexter, B., Bick, R. J., and Darlington, G. J.: C/EBPalpha is required
for differentiation of white, but not brown, adipose tissue, P. Natl.
Acad. Sci. USA, 98, 12532–12537,
https://doi.org/10.1073/pnas.211416898, 2001.
Liu, H., Li, B., Qiao, L., Liu, J., Ren, D., and Liu, W.: miR-340-5p
inhibits sheep adipocyte differentiation by targeting ATF7, Anim. Sci. J.,
91, e13462, https://doi.org/10.1111/asj.13462, 2020.
Liu, P., Ma, C., Wu, Q., Zhang, W., Wang, C., Yuan, L., and Xi, X.:
MiR-369-3p participates in endometrioid adenocarcinoma via the regulation of
autophagy, Cancer Cell Int., 19, 178,
https://doi.org/10.1186/s12935-019-0897-8, 2019.
Livak, K. J. and Schmittgen, T. D.: Analysis of relative gene expression
data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method,
Methods, 25, 402–408, https://doi.org/10.1006/meth.2001.1262, 2001.
Lorente-Cebrián, S., Mejhert, N., Kulyté, A., Laurencikiene, J.,
Åström, G., Hedén, P., Rydén, M., and Arner, P.: MicroRNAs
regulate human adipocyte lipolysis: effects of miR-145 are linked to
TNF-α, PLoS One, 9, e86800,
https://doi.org/10.1371/journal.pone.0086800, 2014.
Lou, J., Huang, J., Dai, X., Xie, Y., Dong, M., and Chen, B.: Knockdown of
tetraspanin 13 inhibits proliferation of colorectal cancer cells, Int. J.
Clin. Exp. Med., 10, 6387–6395, 2017.
Mizushima, N. and Levine, B.: Autophagy in mammalian development and
differentiation, Nat. Cell Biol., 12, 823–830,
https://doi.org/10.1038/ncb0910-823, 2010.
Mortimer, S. I., Hatcher, S., Fogarty, N. M., van der Werf, J. H. J., Brown,
D. J., Swan, A. A., Jacob, R. H., Geesink, G. H., Hopkins, D. L., Edwards,
J. E. H., Ponnampalam, E. N., Warner, R. D., Pearce, K. L., and Pethick, D.
W.: Genetic correlations between wool traits and meat quality traits in
Merino sheep, J. Anim. Sci., 95, 4260–4273,
https://doi.org/10.2527/jas2017.1628, 2017.
Moxnes, J. F., Haux, J., and Hausken, K.: The dynamics of cell
proliferation, Med. Hypotheses, 62, 556–563,
https://doi.org/10.1016/j.mehy.2003.12.007, 2004.
Raj, A. B., Leach, M. C., and Morton, D. B.: Carbon dioxide for euthanasia
of laboratory animals, Comp. Med., 54, 470–471, 2004.
Retzer-Lidl, M., Schmid, R. M., and Schneider, G.: Inhibition of CDK4
impairs proliferation of pancreatic cancer cells and sensitizes towards
TRAIL-induced apoptosis via downregulation of survivin, Int. J. Cancer, 121,
66–75, https://doi.org/10.1002/ijc.22619, 2007.
Rodriguez-Puebla, M. L., Miliani de Marval, P. L., LaCava, M., Moons, D. S.,
Kiyokawa, H., and Conti, C. J.: Cdk4 deficiency inhibits skin tumor
development but does not affect normal keratinocyte proliferation, Am. J.
Pathol., 161, 405–411, https://doi.org/10.1016/s0002-9440(10)64196-x, 2002.
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K., Milstone, D.
S., Spiegelman, B. M., and Mortensen, R. M.: PPAR gamma is required for the
differentiation of adipose tissue in vivo and in vitro, Mol. Cell, 4,
611–617, https://doi.org/10.1016/s1097-2765(00)80211-7, 1999.
Scalavino, V., Liso, M., Cavalcanti, E., Gigante, I., Lippolis, A.,
Mastronardi, M., Chieppa, M., and Serino, G.: miR-369-3p modulates inducible
nitric oxide synthase and is involved in regulation of chronic inflammatory
response, Sci. Rep., 10, 15942, https://doi.org/10.1038/s41598-020-72991-8,
2020.
Xu, Q. and Liu, K.: MiR-369-3p inhibits tumorigenesis of hepatocellular
carcinoma by binding to PAX6, J. Biol. Reg. Homeos. Ag., 34, 917–926,
https://doi.org/10.23812/20-187-a-35, 2020.
Xu, Q., Mariman, E. C. M., Roumans, N. J. T., Vink, R. G., Goossens, G. H.,
Blaak, E. E., and Jocken, J. W. E.: Adipose tissue autophagy related gene
expression is associated with glucometabolic status in human obesity,
Adipocyte, 7, 12–19, https://doi.org/10.1080/21623945.2017.1394537, 2018.
Yekta, S., Shih, I. H., and Bartel, D. P.: MicroRNA-directed cleavage of
HOXB8 mRNA, Science, 304, 594–596, https://doi.org/10.1126/science.1097434,
2004.
Yin, Y., Yuan, H., Wang, C., Pattabiraman, N., Rao, M., Pestell, R. G., and
Glazer, R. I.: 3-phosphoinositide-dependent protein kinase-1 activates the
peroxisome proliferator-activated receptor-gamma and promotes adipocyte
differentiation, Mol. Endocrinol., 20, 268–278,
https://doi.org/10.1210/me.2005-0197, 2006.
Short summary
In this study, we found that miR-369-3p inhibits the proliferation and differentiation of Aohan fine-wool sheep (AFWS) preadipocytes. This study provides a theoretical basis for further exploration of the molecular mechanism of fat deposition in sheep and other livestock.
In this study, we found that miR-369-3p inhibits the proliferation and differentiation of Aohan...
