Articles | Volume 65, issue 4
Original study
08 Dec 2022
Original study |  | 08 Dec 2022

Antibiotic resistance and biofilm formation in Staphylococcus aureus isolated from dairy cows at the stage of subclinical mastitis in northern Kazakhstan

Raushan Rychshanova, Anara Mendybayeva, Bartosz Miciński, Nurlan Mamiyev, Pavel Shevchenko, Zhanaidar Bermukhametov, Bartosz Orzechowski, and Jan Miciński

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Cited articles

Ali Gharieb, R. M., Saad, M. F., Mohamed, A. S., and Tartory, Y. H.: Characterization of two novel lytic bacteriophages for reducing biofilms of zoonotic multidrug-resistant Staphylococcus aureus and controlling their growth in milk, LWT, 124, 109–145,, 2020. 
Argudin, M. A., Tenhagen, B. A., Fetsch, A., Sachsenroder, J., Kasbohrer, A., Schroeter, A., Hammerl, J. A., Hertwig, S., Helmuth, R., Braunig, J., Mendoza, M. C., Appel, B., Rodicio, M. R., and Guerra, B.: Virulence and Resistance Determinants of German Staphylococcus aureus ST398 Isolates from Nonhuman Sources, Appl. Environ. Microb., 77, 3052–3060,, 2011. 
Aslantaş, Ö. and Demir, C.: Investigation of the antibiotic resistance and biofilm-forming ability of Staphylococcus aureus from subclinical bovine mastitis cases, J. Dairy Sci., 99, 8607–8613,, 2016. 
Barkema, H. W., Schukken, Y. H., and Zadoks, R. N.: Invited Review: The Role of Cow, Pathogen, and Treatment Regimen in the Therapeutic Success of Bovine Staphylococcus aureus Mastitis, J. Dairy Sci., 89, 1877–1895,, 2006. 
Belmamoun, A. R., Reguig, K. B., Bouazza, S., Dif, M. M.: Subclinical mastitis on the raw milk as a risk factor for the transmission of Staphylococcus aureus and coagulase-negative staphylococci, multidrug resistance in Sidi Bel Abbes, Algeria, Adv. Environ. Biol., 10, 1–11, (last access: 4 December 2022), 2016. 
Short summary
We show that Staphylococcus aureus isolates obtained from cow milk at the stage of subclinical mastitis were resistant to antibiotics used to treat mastitis. The ability to form biofilms increases the opportunity for the spread of multidrug-resistant strains. S. aureus isolates carried resistance genes, most encoding resistance to β-lactams and tetracyclines. S. aureus in raw milk poses a potential risk of developing foodborne infections and spread of antibiotic resistance between species.