Articles | Volume 65, issue 3
Arch. Anim. Breed., 65, 309–318, 2022
Arch. Anim. Breed., 65, 309–318, 2022
Original study
12 Aug 2022
Original study | 12 Aug 2022

Meta-analysis of association between c.963A>G single-nucleotide polymorphism on BMP15 gene and litter size in goats

Emel Zergani et al.

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Cited articles

Ahlawata, S., Sharmaa, R., Royb, M., Mandakmalec, S., Prakashd, V., and Tantiaa, M. S.: Genotyping of Novel SNPs in BMPR1B, BMP15, and GDF9 Genes for Association with Prolificacy in Seven Indian Goat Breeds, Anim. Biotechnol., 27, 199–207,, 2016. 
Araújo, A. M. D., Guimarães, S. E. F., Carmen Silva Pereira, C. S., Lopes, P. S., Rodrigues, M. T., and Machado, T. M. M.: Paternity in Brazilian goats through the use of DNA microsatellites, Rev. Bras. Zootec., 39, 1011–1014, 2010. 
Chu, M. X., Jiao, C. L., He, Y. Q., Wang, J. Y., Liu, Z. H., and Chen, G. H.: Association Between PCR-SSCP of Bone Morphogenetic Protein 15 Gene and Prolificacy in Jining Grey Goats, Anim. Biotechnol., 18, 263–274,, 2007. 
Di, R., Wang, F., Yu, P., Wang, X., He, X., Mwacharo, J. M., Pan, L., and Chu, M.: Detection of Novel Variations Related to Litter Size in BMP15 Gene of Luzhong Mutton Sheep (Ovis aries), Animals, 11, 3528,, 2021. 
Dong, C. H. and Du, L. X.: Polymorphism Analysis of BMP15 Gene Related to Reproduction Trait of Goat Breeds in Shandong Province, Chin. J. Zool., 45, 59–69,, 2010. 
Short summary
Different studies have reported controversial results regarding the effects of c.963A>G polymorphism in the BMP15 gene on litter size in goats. We conducted a meta-analysis by using data of all published relevant studies to address this contradiction and found a significant association between c.963A>G polymorphism and litter size at birth under dominant and additive genetic models. The meta-analysis results revealed that the AA genotype could be positively connected with litter size in goats.