Articles | Volume 64, issue 2
Arch. Anim. Breed., 64, 345–353, 2021
Arch. Anim. Breed., 64, 345–353, 2021

Original study 19 Aug 2021

Original study | 19 Aug 2021

Regulating glycolysis and heat shock proteins in Gannan yaks (Bos grunniens) in response to hypoxia of the Qinghai–Tibet Plateau

Yuliang Wen et al.

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Cited articles

Beall, C. M.: Two routes to functional adaptation: Tibetan and Andean high-altitude natives, P. Natl. Acad. Sci. USA, 104, 8655–8660,, 2007. 
Díaz Villanueva, J. F., Díaz Molina, R., and García-González, V.: Protein Folding and Mechanisms of Proteostasis, Int. J. Mol. Sci., 16, 17193–17230,, 2015. 
Ding, Y. P., Liu, J. F., Xu, Y. Q., Dong, X. P., and Shao, B. P.: Evolutionary Adaptation of Aquaporin-4 in Yak (Bos grunniens) Brain to High-Altitude Hypoxia of Qinghai-Tibetan Plateau, High. Alt. Med. Biol., 21, 167–175,, 2020. 
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Short summary
The regulation of glycolysis and heat shock proteins (HSPs) in Gannan yaks at different altitudes were determined. We found that HIF1A and PDK4 expression and glycolysis-related enzyme level were significantly increased, but CA level was significantly decreased with altitude. HSP27 and HSP60 were highly expressed with altitude. These results are useful to better understand the unique adaptability of Gannan yaks, allowing them to survive in hypoxia conditions.