Articles | Volume 64, issue 1
Arch. Anim. Breed., 64, 147–155, 2021
https://doi.org/10.5194/aab-64-147-2021
Arch. Anim. Breed., 64, 147–155, 2021
https://doi.org/10.5194/aab-64-147-2021

Original study 30 Apr 2021

Original study | 30 Apr 2021

Detection of genetic variation and activity analysis of the promoter region of the cattle tRNA-modified gene TRDMT1

Xiaohua Yi et al.

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Cited articles

Alexandrov, A., Chernyakov, I., Gu, W., Hiley, S. L., Hughes, T. R., Grayhack, E. J., and Phizicky, E. M.: Rapid tRNA decay can result from lack of nonessential modifications, Mol. Cell, 21, 87–96, https://doi.org/10.1016/j.molcel.2005.10.036, 2006. 
Bohnsack, K. E., Höbartner, C., and Bohnsack, M. T.: Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease, Genes, 10, 102, https://doi.org/10.3390/genes10020102, 2019. 
Cătoi, A. F., Pârvu, A., Mureşan, A., and Busetto, L.: Metabolic Mechanisms in Obesity and Type 2 Diabetes: Insights from Bariatric/Metabolic Surgery, Obesity Facts, 8, 350–363, https://doi.org/10.1159/000441259, 2015. 
Chen, H., Yang, H., Zhu, X., Yadav, T., Ouyang, J., Truesdell, S. S., Tan, J., Wang, Y., Duan, M., Wei, L., Zou, L., Levine, A. S., Vasudevan, S., and Lan, L.: m5C modification of mRNA serves a DNA damage code to promote homologous recombination, Nat. Commun., 11, 2834, https://doi.org/10.1038/s41467-020-16722-7, 2020. 
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In this experiment, by detecting the mutation in the promoter region of the bovine TRDMT1 gene, fluorescent recombinant plasmids of different genotypes were constructed at this site, and the relative fluorescence intensity was analyzed by detecting the transfected 293T cells. Our experiment detected a natural genetic variation of a tRNA modification gene TRDMT1, which may provide potential natural molecular materials for the study of tRNA modification.