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Articles | Volume 68, issue 2
Articles | Volume 68, issue 2
https://doi.org/10.5194/aab-68-271-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-68-271-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 68, issue 2
Original study
 | 
08 May 2025
Original study |  | 08 May 2025

FASN thioesterase domain mutation and fatty acid profile in Holstein Friesian intramuscular fat

David Cancino-Baier, Erwin Muñoz-Acuña, John Quiñones, Rommy Diaz, Jorge F. Beltrán, Jorge Farías, Karla Inostroza, Rodrigo Huaiquipan, José Bento Sterman Ferraz, and Néstor Sepúlveda

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Short summary
A mutation in the thioesterase domains of the fatty acid synthase enzyme reduces the percentage of myristic acid. In silico simulations were performed to assess the mutation's impact on the catalytic site's affinity for ligands and its effect on intramuscular fatty acid profiles. Tertiary structures were generated, revealing increased affinity between the mutated enzyme and myristoyl. However, the structural changes have a more significant impact on the fatty acid profile than the altered affinity.
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