Articles | Volume 67, issue 1
https://doi.org/10.5194/aab-67-81-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-67-81-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Association analysis of single nucleotide polymorphisms in the sheep FecB gene with reproductive and body size performance
Lingchao Kong
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Shuaitong Li
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Yuan Pan
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Jiaqi Li
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Siyi Li
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Yining Liu
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Sibing Hou
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Qingkun Liu
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Yanjun Qiao
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Yinggang Sun
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Zeying Wang
CORRESPONDING AUTHOR
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Related authors
Hua Ma, Weihang Hong, Lingjun Nie, Shuaitong Li, Qingyu Yuan, Ran Duan, Qiying Zhan, Lingchao Kong, and Zeying Wang
Arch. Anim. Breed., 68, 135–149, https://doi.org/10.5194/aab-68-135-2025, https://doi.org/10.5194/aab-68-135-2025, 2025
Short summary
Short summary
This study investigated single-nucleotide polymorphism (SNP) in the keratin 27 (KRT27, 1919G/A) and elongation of very-long-chain fatty acids 4 (ELOVL4, 28666C/T) genes, which are associated with production traits in Liaoning cashmere goats. Multivariate analysis was also conducted. The GGCC genotype combination was associated with finer cashmere quality. The GGTT haplotype exhibited a multigenic effect. The TT genotype demonstrated pleiotropy.
Hua Ma, Weihang Hong, Lingjun Nie, Shuaitong Li, Qingyu Yuan, Ran Duan, Qiying Zhan, Lingchao Kong, and Zeying Wang
Arch. Anim. Breed., 68, 135–149, https://doi.org/10.5194/aab-68-135-2025, https://doi.org/10.5194/aab-68-135-2025, 2025
Short summary
Short summary
This study investigated single-nucleotide polymorphism (SNP) in the keratin 27 (KRT27, 1919G/A) and elongation of very-long-chain fatty acids 4 (ELOVL4, 28666C/T) genes, which are associated with production traits in Liaoning cashmere goats. Multivariate analysis was also conducted. The GGCC genotype combination was associated with finer cashmere quality. The GGTT haplotype exhibited a multigenic effect. The TT genotype demonstrated pleiotropy.
Yanzhi Wu, Yu Zhang, Yuting Qin, Weidong Cai, Xinjiang Zhang, Yanan Xu, Xingtang Dou, Zhanhong Wang, Di Han, Jiaming Wang, Guangyu Lin, Lingling Wang, Jianjun Hao, Shuqing Fu, Rui Chen, Yinggang Sun, Zhixian Bai, Ming Gu, and Zeying Wang
Arch. Anim. Breed., 65, 145–155, https://doi.org/10.5194/aab-65-145-2022, https://doi.org/10.5194/aab-65-145-2022, 2022
Short summary
Short summary
Our research tried new ideas and measured the milk production performance of cashmere goats and found that the nutritional indicators of milk of Liaoning cashmere goats were excellent, laying a theoretical foundation for the future development of breeding to cashmere goats. At the same time, it also provides theoretical support for producers and can screen individual genotypes based on the experimental results during seed selection, thereby improving production performance to a certain extent.
Junyin Zhao, Jincheng Shen, Zeying Wang, Man Bai, Yixing Fan, Yubo Zhu, and Wenlin Bai
Arch. Anim. Breed., 65, 55–67, https://doi.org/10.5194/aab-65-55-2022, https://doi.org/10.5194/aab-65-55-2022, 2022
Short summary
Short summary
Cashmere is a natural fiber from cashmere goats. The textile has been favored by consumers due to typical features like lightness, softness, and comfort. In this study, we show that circRNA-0100 promotes the differentiation of secondary hair follicle stem cells into hair lineage via sequestering miR-153-3p to heighten the KLF5 expression. Our results provide significant information for artificially regulating the secondary hair follicle regeneration and cashmere growth in cashmere goats.
Related subject area
Reproduction
Effect on OPU/IVEP success of different applications for synchronizing follicular waves prior to superstimulation in holstein heifers
Comparative analysis of metabolic, reproductive, and sub-clinical mastitis in pure Holstein-Friesian and Sahiwal-crossbred cows
Sonograms of perineal muscles as a noninvasive diagnosis of pyometra and endometritis in beef cows: a preliminary study
The effect of resveratrol on the cryopreservation of Mongolian horse semen
The effect of different doses of estradiol benzoate on follicle development and twin birth in beef cattle with induced superovulation
Expression of peroxiredoxin-6 in the epididymal microenvironment and sperm of sheep
N-acetylcysteine may improve endometrial receptivity by modulating endometrial stromal cells in goats
Polymorphisms of the HRG, FETUB, and GUCY1A1 genes and their association with litter size in sheep
Improvement of ram semen quality by luteolin enrichment during cold preservation
Effect of protected fatty acid supplementation on ovarian activity, reproductive hormone profiles and reproduction of Barki ewes under semiarid conditions
Effect of water quality on causes of calf mortality in cattle-farm-associated epidemics
Impact of redox status of donor cows before superovulation treatment on in vivo embryo production
Detection of genetic variations in the GDF9 and BMP15 genes in Kazakh meat–wool sheep
Determination of the effect of pre-mating weight and placental characteristics on birth weight in Karayaka sheep
Lin28B overexpression decreases let-7b and let-7g levels and increases proliferation and estrogen secretion in Dolang sheep ovarian granulosa cells
Muhammed Furkan Çiftçi, Ömer Faruk Yeşilkaya, Sakine Ülküm Çizmeci, Maide Gölbaşı, Ayşe Sarı, and Dursun Ali Dinç
Arch. Anim. Breed., 68, 101–107, https://doi.org/10.5194/aab-68-101-2025, https://doi.org/10.5194/aab-68-101-2025, 2025
Short summary
Short summary
In this study, short synchronization methods that do not contain estradiol before superstimulation in ovum pickup (OPU) applications were investigated. The gonadotropin-releasing hormone (GnRH), human chorionic gonadotropin (hCG), and dominant follicle removal (DFR) were used for follicular wave emergence. It was determined that DFR and hCG for follicular wave emergence increased oocyte yield and in vitro embryo production success in pre-superstimulation synchronization protocols.
Shah Murad Khan, Rifat Ullah Khan, Shabana Naz, Ibrahim Abdullah Alhidary, Naseer Khan Momand, and Ruchi Tiwari
Arch. Anim. Breed., 68, 89–100, https://doi.org/10.5194/aab-68-89-2025, https://doi.org/10.5194/aab-68-89-2025, 2025
Short summary
Short summary
Among 180 cows studied postpartum, F2 cows had the highest milk yield (183.9 L per week) and the highest serum glucose. F1 cows showed the best reproductive performance. Holstein-Friesian (HF) cows had the highest somatic cell count, indicating higher mastitis risk. Crossbreeding with Sahiwal improved milk production and reproductive health.
Amrozi, Sari Yanti Hayanti, Aryogi, Dicky Pamungkas, Dicky Mohammad Dikman, Eko Handiwirawan, Fitra Aji Pamungkas, Herdis, Jakaria, and Mokhamad Fakhrul Ulum
Arch. Anim. Breed., 68, 1–12, https://doi.org/10.5194/aab-68-1-2025, https://doi.org/10.5194/aab-68-1-2025, 2025
Short summary
Short summary
The cow's perineal muscle is connected to the rectum, vulva, and vagina. The author hypothesizes that changes in reproductive status affect perineal muscle tension, which will affect the anatomy of the coccygeus and levator ani muscles. The sonograms we obtained showed a significant increase in the coccygeus and levator ani muscles of pyometra cows compared to endometritis, nonpartum pregnant, pregnant, and postpartum pregnant cows.
Ming Du, Yuanyi Liu, Lei Zhang, Xinyu Li, Na Wang, Qianqian He, Jialong Cao, Bilig Zhao, Yujie Shi, Bei Li, Gerelchimeg Bou, and Manglai Dugarjaviin
Arch. Anim. Breed., 68, 27–41, https://doi.org/10.5194/aab-68-27-2025, https://doi.org/10.5194/aab-68-27-2025, 2025
Short summary
Short summary
Cryopreservation of semen faces challenges due to oxidative stress. Researchers found that adding resveratrol (RSV) at 10-40 μmol L-1 to Mongolian horse semen improved sperm quality, with best results at 40 μmol L-1. Proteomic analysis showed increased antioxidant proteins. Further tests confirmed RSV's potential as an effective antioxidant for enhancing semen cryopreservation, offering promise for overcoming these challenges.
Weibin Zeng, Lei An, Yanping Wang, Xinli Gu, Yusheng Qin, and Jianhui Tian
Arch. Anim. Breed., 67, 533–539, https://doi.org/10.5194/aab-67-533-2024, https://doi.org/10.5194/aab-67-533-2024, 2024
Short summary
Short summary
Cattle are monovular and naturally single-birth animals, producing only one calf per year. In this work, we evaluated the effect of inducing twin calves in beef heifers using different hormone treatment regimes. Animals were randomly selected for the procedure that induced double/triple ovulation via hormone treatment. This method may serve to promote twin production in beef cattle.
Jiaoxia Xu, Jian Zhang, Yukun Song, Gaowa Hasi, Zhaojin Luan, Wei Du, and Jiaxin Zhang
Arch. Anim. Breed., 67, 393–399, https://doi.org/10.5194/aab-67-393-2024, https://doi.org/10.5194/aab-67-393-2024, 2024
Short summary
Short summary
Peroxiredoxin-6 (PRDX6) is expressed in the epididymal tissue, epididymal fluid, and epididymal sperm of sheep. As the sperm mature and transit through the epididymis, the intracellular distribution of PRDX6 gradually becomes more extensive. This suggests that PRDX6 has an important role in promoting sperm maturation.
Kaibin Fu, Xiang Chen, Xingzhou Tian, Wen Tang, Ting Gong, Yan Zhang, and Taotao Ji
Arch. Anim. Breed., 67, 361–372, https://doi.org/10.5194/aab-67-361-2024, https://doi.org/10.5194/aab-67-361-2024, 2024
Short summary
Short summary
We used endometrial stromal cells of Qianbei Ma goats as our study subjects and found that N-acetylcysteine could promote the proliferation of endometrial stromal cells and increase the viability, antioxidant activity, mitochondrial membrane potential and expression of endometrial receptivity marker genes of endometrial stromal cells, which suggests that N-acetylcysteine may be beneficial in improving endometrial receptivity of goats.
Zizhen Ren, Xiaoyun He, Xiangyu Wang, and Mingxing Chu
Arch. Anim. Breed., 67, 153–161, https://doi.org/10.5194/aab-67-153-2024, https://doi.org/10.5194/aab-67-153-2024, 2024
Short summary
Short summary
The g.405442728A>G locus of HRG exhibited moderate polymorphism (0.25<PIC<0.5) in these breeds, indicating this locus has great selection potential. It is accurate to say HRG can be used as a molecular marker to increase litter size in Small-tailed Han sheep (STH). The g.405442728A>G locus of HRG and the g.421655951C>T locus of FETUB had a significant effect on litter size in STH (P<0.05). We can use HRG and FETUB as candidate genes for the selection of litter size in sheep breeding.
Sharif Khozein, Mohsen Eslami, and Farhad Farrokhi-Ardabili
Arch. Anim. Breed., 67, 123–132, https://doi.org/10.5194/aab-67-123-2024, https://doi.org/10.5194/aab-67-123-2024, 2024
Short summary
Short summary
The current study was designed to evaluate the probable protective effect of luteolin against lipid peroxidation of ram spermatozoa membranes and kinematics during cold preservation. Results indicated that luteolin was able to improve the kinematics of spermatozoa during liquid storage. Enzymatic and total antioxidants were improved by luteolin enrichment. Luteolin did not affect the nitrosative index of stored ram spermatozoa after 72 h.
Bahaa Farrag, Khalid Ahmed El-Bahrawy, Hesham Attia Shedeed, and Muhammed Ahmed-Hilmy El-Rayes
Arch. Anim. Breed., 67, 111–122, https://doi.org/10.5194/aab-67-111-2024, https://doi.org/10.5194/aab-67-111-2024, 2024
Short summary
Short summary
Our study suggests that dietary supplementation in Barki ewes prior to mating is effective in maintaining reproductive performance. This improvement is evident through increased levels of hormonal profiles, numbers and sizes of ovarian follicles, improved conception, and lambing rates. In fact, the effects of protected fats are most pronounced when combined with hormonal treatments.
Mohammed A. Kamal, Mahmoud A. Khalf, Zakia A. M. Ahmed, Jakeen A. Eljakee, Rashed A. Alhotan, Mohammed A. A. Al-Badwi, Elsayed O. Hussein, Branislav Galik, and Ahmed A. Saleh
Arch. Anim. Breed., 67, 25–35, https://doi.org/10.5194/aab-67-25-2024, https://doi.org/10.5194/aab-67-25-2024, 2024
Short summary
Short summary
Poor-quality drinking water plays a detrimental role in the suppression of calf immunity, giving rise to an increased rate of calf mortality. The present study aims to evaluate the causes of calf mortality in beef and dairy farms in relation to drinking water quality (DWQ). We could conclude that DWQ highly affects causes of calf mortality, but we cannot exclude some farm hygienic risk factors.
Shogo Hashimoto, Masayasu Taniguchi, Ayane Edo, Tetsushi Ono, Tetty Barunawati Siagian, Hiroaki Sekine, Megumi Nagahara, Takeshige Otoi, and Mitsuhiro Takagi
Arch. Anim. Breed., 66, 433–437, https://doi.org/10.5194/aab-66-433-2023, https://doi.org/10.5194/aab-66-433-2023, 2023
Short summary
Short summary
This study aimed to investigate the relationship between oxidation and antioxidation parameters before superovulation (SOV) treatment and embryo recovery in donor cows. The redox status of donor cows before SOV treatment affects embryo recovery, as cows with high levels of both oxidative and antioxidative status have better embryo production. This information will be useful for the selection of donor cows and subsequent treatments.
Makpal Amandykova, Zarina Orazymbetova, Tilek Kapassuly, Altynay Kozhakhmet, Saltanat Khamzina, Kairat Iskakov, and Kairat Dossybayev
Arch. Anim. Breed., 66, 401–409, https://doi.org/10.5194/aab-66-401-2023, https://doi.org/10.5194/aab-66-401-2023, 2023
Short summary
Short summary
Sheep breeding is one of the leading livestock sectors in agricultural countries, including Kazakhstan. A comprehensive study of the genetic aspects of these animals will solve many issues of the effectiveness of sheep breeding. This is important for such little-studied breeds as the Kazakh meat–wool sheep breed, which are multifetal. In this study, for the first time, we characterized this breed by looking at fecundity genes and found mutations that positively affect sheep fertility.
Samet Urun and Emre Şirin
Arch. Anim. Breed., 66, 335–340, https://doi.org/10.5194/aab-66-335-2023, https://doi.org/10.5194/aab-66-335-2023, 2023
Short summary
Short summary
The aim of this work was to determine the effect of the pre-mating weight (PMW) and placental characteristics on the birth weight (BW). Although prior studies have determined a relationship between BW and placental characteristics, no existing work has determined a relationship between the PMW and BW. This is also the first study in which placental surface area is used as a factor for determining the relationship between placental characteristics and BW.
Zhiyuan Sui, Yongjie Zhang, Zhishuai Zhang, Chenguang Wang, Xiaojun Li, and Feng Xing
Arch. Anim. Breed., 66, 217–224, https://doi.org/10.5194/aab-66-217-2023, https://doi.org/10.5194/aab-66-217-2023, 2023
Short summary
Short summary
There are few studies investigating the RNA-binding protein Lin28B and ovine puberty. This study focuses on understanding how its overexpression changes microRNA levels, cell proliferation, and estrogen secretion. To assess these changes, we used quantitative real-time (qRT) PCR, overexpression vectors, and ELISA. We found that Lin28B overexpression decreases let-7b and let-7g levels and increases granulosa cell proliferation and their estrogen secretion.
Cited articles
Akhatayeva, Z., Bi, Y., He, Y., Khan, R., Li, J., Li, H., Pan, C., and Lan, X.: Survey of the relationship between polymorphisms within the BMPR1B gene and sheep reproductive traits, Anim. Biotechnol., 34, 718–727, https://doi.org/10.1080/10495398.2021.1979023, 2023.
Chu, M., Jia, L., Zhang, Y., Jin, M., Chen, H., Fang, L., Di, R., Cao, G., Feng, T., Tang, Q., Ma, Y., and Li, K.: Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep, Mol. Biol. Rep., 38, 4071–4076, https://doi.org/10.1007/s11033-010-0526-z, 2011.
Cui, X., Wang, J., Wang, D., Zhang, G., Wang, K., Huang, Q., and Meng, X.: Effect of FecB gene on litter sice and lamb growth and development of Dorper × Han crossbred sheep, Shandong Agricultural Sciences, 98, 98–100, http://www.sdnykx.cbpt.cnki.net/WKC/WebPublication/paperDigest.aspx?paperID=225ca07a-19eb-4701-9d6f-496dbf38b75c (last access: 11 February 2024), 2010.
Davis, G. H., Galloway, S. M., Ross, I. K., Gregan, S. M., Ward, J., Nimbkar, B. V., Ghalsasi, P. M., Nimbkar, C., Gray, G. D., Subandriyo, Inounu, I., Tiesnamurti, B., Martyniuk, E., Eythorsdottir, E., Mulsant, P., Lecerf, F., Hanrahan, J. P., Bradford, G. E., and Wilson, T.: DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation, Biol. Reprod., 66, 1869–1874, https://doi.org/10.1095/biolreprod66.6.1869, 2002.
Davis, G. H., Balakrishnan, L., Ross, I. K., Wilson, T., Galloway, S. M., Lumsden, B. M., Hanrahan, J. P., Mullen, M., Mao, X. Z., Wang, G. L., Zhao, Z. S., Zeng, Y. Q., Robinson, J. J., Mavrogenis, A. P., Papachristoforou, C., Peter, C., Baumung, R., Cardyn, P., Boujenane, I., Cockett, N. E., Eythorsdottir, E., Arranz, J. J., and Notter, D. R.: Investigation of the Booroola (FecB) and Inverdale (FecX(I)) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries, Anim. Reprod. Sci., 92, 87–96, https://doi.org/10.1016/j.anireprosci.2005.06.001, 2006.
Gao, Y., Hao, Q., Cang, M., Wang, J., Yu, H., Liu, Y., Zhang, W., and Tong, B.: Association between novel variants in BMPR1B gene and litter size in Mongolia and Ujimqin sheep breeds, Reprod. Domest. Anim., 56, 1562–1571, https://doi.org/10.1111/rda.14020, 2021.
Gong, Y. M., Wang, X. Y., He, X. Y., Liu, Y. F., Yu, P., Chu, M. X., and Di, R.: Progress on the effect of FecB mutation on BMPR1B activity and BMP/SMAD pathway in sheep, Yichuan Hereditas, 45, 295–305, http://www.chinagene.cn/CN/10.16288/j.yczz.22-366 (last access: 11 February 2024), 2023.
Gootwine, E., Rozov, A., Bor, A., and Reicher, S.: Carrying the FecB (Booroola) mutation is associated with lower birth weight and slower post-weaning growth rate for lambs, as well as a lighter mature bodyweight for ewes, Reprod. Fert. Develop., 18, 433–437, https://doi.org/10.1071/rd05134, 2006.
Guan, F., Liu, S. R., Shi, G. Q., and Yang, L. G.: Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development, Anim. Reprod. Sci., 99, 44–52, https://doi.org/10.1016/j.anireprosci.2006.04.048, 2007.
Guo, X.: Study on Molecular Mechanism of FecB Gene for Fecundity in Small Tail Han Sheep, China Agricultural University, 2018.
Hua, G. H. and Yang, L. G.: A review of research progress of FecB gene in Chinese breeds of sheep, Anim. Reprod. Sci., 116, 1–9, https://doi.org/10.1016/j.anireprosci.2009.01.001, 2009.
Lander, E. S.: The new genomics: global views of biology, Science, 274, 536–539, https://doi.org/10.1126/science.274.5287.536, 1996.
Liu, Q., Pan, Z., Wang, X., Wenping, H. U., Ran, D. I., Yao, Y., and Chu, M.: Progress on major genes for high fecundity in ewes, Front. Agr. Sci. Eng., 33, 953–961, https://doi.org/10.15302/J-FASE-2014042, 2014.
Liu, S. F., Jiang, Y. L., and Du, L. X.: Studies of BMPR-IB and BMP15 as candidate genes for fecundity in little tailed han sheep, Yi chuan xue bao, J. Genet. Genomics, 30, 755–760, 2003.
Luo, S.: Study on Breeding multiple lambs type of Kazakh sheep by FecB polyfetal gene introduction, Heilongjiang Journal of Animal Reproduction, 25, 7–10, 2017.
Mulsant, P., Lecerf, F., Fabre, S., Schibler, L., Monget, P., Lanneluc, I., Pisselet, C., Riquet, J., Monniaux, D., Callebaut, I., Cribiu, E., Thimonier, J., Teyssier, J., Bodin, L., Cognié, Y., Chitour, N., and Elsen, J. M.: Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes, P. Natl. Acad. Sci. USA, 98, 5104–5109, https://doi.org/10.1073/pnas.091577598, 2001.
Nan, J., Chen, G., Zhang, J., Huang, X., Hai, L., Guo, L., Zhang, B., and Zhang, G.: Research status of prolificacy gene in sheep, Modern Journal of Animal Husbandry and Veterinary Medicine, 11, 75–78, 2022.
Näsholm, A. and Danell, O.: Genetic relationships of lamb weight, maternal ability, and mature ewe weight in Swedish finewool sheep, J. Anim. Sci., 74, 329–339, https://doi.org/10.2527/1996.742329x, 1996.
Oraon, T., Singh, D. K., Ghosh, M., Kullu, S. S., Kumar, R., and Singh, L. B.: Allelic and genotypic frequencies in polymorphic Booroola fecundity gene and their association with multiple birth and postnatal growth in Chhotanagpuri sheep, Veterinary World, 9, 1294–1299, https://doi.org/10.14202/vetworld.2016.1294-1299, 2016.
Park, E., Cho, M., and Ki, C. S.: Correct use of repeated measures analysis of variance, Kor. J. Lab. Med., 29, 1–9, https://doi.org/10.3343/kjlm.2009.29.1.1, 2009.
Sejian, V., Maurya, V. P., Prince, L. L., Kumar, D., and Naqvi, S. M.: Effect of FecB status on the allometric measurements and reproductive performance of Garole × Malpura ewes under hot semi-arid environment, Trop. Anim. Health Prod., 47, 1089–1093, https://doi.org/10.1007/s11250-015-0831-6, 2015.
Souza, C. J., MacDougall, C., MacDougall, C., Campbell, B. K., McNeilly, A. S., and D. T., B.: The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene, J. Endocrinol., 169, R1–6, https://doi.org/10.1677/joe.0.169r001, 2001.
Xie, L., Miao, X., Luo, Q., Zhao, H., and Qin, X.: Impact of FecB Mutation on Ovarian DNA Methylome in Small-Tail Han Sheep, Genes, 14, 203, https://doi.org/10.3390/genes14010203, 2023.
Xu, Z., Niu, C. E., Zhao, F., Li, S., Gao, Y., and Yang, B.: Current Status, Main Application Technology and Prospect of Sheep Breeding in China, China Herbivore Science, 40, 60–65, https://doi.org/10.3969/j.issn.2095-3887.2020.02.014, 2020.
Yang, C., Zhang, Z., Tang, H., Guo, Y., Ren, X., Wang, L., and Zhou, P.: Research Progress of FecB Gene on Reproductive Performance of Sheep, Acta Veterinaria et Zootechnica Sinica, 54, 1370–1380, 2023.
Yu, Z., He, Z., Wurelihazi, Liu, Q., Meng, R., Yao, J., and Sai, W.: Expression of Hu sheep FecB gene in fetal fibroblasts of Xinjiang Fine-wool sheep, Prog. Vet. Med., 33, 99–102, https://10.16437/j.cnki.1007-5038.2012.06.030, 2012.
Zhang, Y., Airixiati, D., Liu, Z., Aikebaier, A., Song, Y., Li, J., Wang, X., and Abulizi, W.: Effect of FecB gene on lambing percentage and growth performance of cross offspring of Doper and Hu sheep, China Herbivore Science, 41, 69–72, 2021.
Zhou, S., Ding, Y., Liu, J., Liu, Y., Zhao, X., Li, G., Zhang, C., Li, C., Wang, Y., Kalds, P., Gao, Y., Zong, B., Huang, X., Huang, S., Yu, H., Kou, Q., Petersen, B., Huang, X., Wang, X., Ma, B., and Chen, Y.: Highly efficient generation of sheep with a defined FecB(B) mutation via adenine base editing, Genet. Sel. Evol., 52, 35, https://doi.org/10.1186/s12711-020-00554-6, 2020.
Short summary
In this study, we investigated the effect of the sheep FecB gene on reproductive and productive performance by molecular biology techniques. Our results showed that the most dominant genotypes associated with lambing performance were AA and CT, with the dominant haplotype combination being AACT. In terms of body performance, the dominant genotypes were AA and CC, with the dominant haplotype combination being AACC.
In this study, we investigated the effect of the sheep FecB gene on reproductive and productive...