Articles | Volume 66, issue 1
https://doi.org/10.5194/aab-66-81-2023
https://doi.org/10.5194/aab-66-81-2023
Original study
 | 
23 Feb 2023
Original study |  | 23 Feb 2023

Selection signature analysis reveals RDH5 performed key function in vision during sheep domestication process

Ruixue Hu, Xunping Jiang, Huiguo Yang, and Guiqiong Liu

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Latest update: 19 Jun 2024
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Short summary
Genes enriched in sensory perception were positively selected via selection signature analysis between wild Asiatic mouflon and domesticated Hu sheep. Among them, RDH5 is one of the key enzymes in the synthesis of retinoic acid (RA), which is related to human retinopathy. The c.722T>C/p.M241T mutation of RDH5 affects retinol dehydrogenase activity in the domestication process of sheep.