Articles | Volume 66, issue 4
https://doi.org/10.5194/aab-66-401-2023
https://doi.org/10.5194/aab-66-401-2023
Original study
 | 
07 Dec 2023
Original study |  | 07 Dec 2023

Detection of genetic variations in the GDF9 and BMP15 genes in Kazakh meat–wool sheep

Makpal Amandykova, Zarina Orazymbetova, Tilek Kapassuly, Altynay Kozhakhmet, Saltanat Khamzina, Kairat Iskakov, and Kairat Dossybayev

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Cited articles

Abdelgadir, A. Z., Musa, L. M. A., Jawasreh, K. I., Saleem, A. O., El-Hag, F., and Ahmed, M. A.: G1 point mutation in growth differentiation factor 9 gene affects litter size in Sudanese desert sheep, Vet. World, 14, 104–112, https://doi.org/10.14202/vetworld.2021.104-112, 2021. 
Abdoli, R., Zamani, P., Deljou, A., and Rezvan, H.: Association of BMPR-1B and GDF9 genes polymorphisms and secondary protein structure changes with reproduction traits in Mehraban ewes, Gene, 524, 296–303, https://doi.org/10.1016/j.gene.2013.03.133, 2013. 
Alzohairy, A. M.: BioEdit: An important software for molecular biology, Gerf. Bull. Biosci., 2, 60–61, 2011. 
Bai, J., Shi, H. C., Liu, M. J., and Li, F.: Study on GDF9 and BMP15 as candidate genes for fecundity in Cele Black sheep and Duolang sheep, Grass-Feed Livestock, 2, 1–4, 2007. 
Ben, J. S., Ruesche, J., Sarry, J., Woloszyn, F., Lassoued, N., and Fabre, S.: The high prolificacy of D'man sheep is associated with the segregation of the FecLL mutation in the B4GALNT2 gene, Reprod. Domest. Anim., 54, 531–537, https://doi.org/10.1111/rda.13391, 2019. 
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Short summary
Sheep breeding is one of the leading livestock sectors in agricultural countries, including Kazakhstan. A comprehensive study of the genetic aspects of these animals will solve many issues of the effectiveness of sheep breeding. This is important for such little-studied breeds as the Kazakh meat–wool sheep breed, which are multifetal. In this study, for the first time, we characterized this breed by looking at fecundity genes and found mutations that positively affect sheep fertility.