Articles | Volume 65, issue 3
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Genetic polymorphism of Pit-1 and CSN3 genes in Holstein calves and its associations with calf birth weight
Department of Animal Science, Faculty of Agriculture, Atatürk University, 25240 Erzurum, Türkiye
Department of Animal Science, Faculty of Agriculture, Atatürk University, 25240 Erzurum, Türkiye
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Memis Ozdemir, Sinan Kopuzlu, Mehmet Topal, and Omer Cevdet Bilgin
Arch. Anim. Breed., 61, 197–206,Short summary
The meta-analysis demonstrated that the relationships of major milk protein genes with other factors should be examined using the codominant genetic model in general. According to results of the meta-analysis, relationships among some CSN3 genotypes and fat yield, fat content, and protein content, and relationships among some BLG genotypes and daily milk yield, fat content, protein yield, and protein content were found statistically significant (p < 0.05).
Related subject area
Subject: DNA markers and gene expressions | Animal: CattleMitochondrial DNA diversity of D-loop region in three native Turkish cattle breedsAssessment of the association of the MOGAT1 and MOGAT3 gene with growth traits in different growth stages in Holstein calvesThe relationships between κ-casein (CSN3) gene polymorphism and some performance traits in Simmental cattleAllele-specific polymerase chain reaction for the discrimination of elite Korean cattle associated with high beef quality and quantityDetermination of the association of GHR/AluI gene polymorphisms with milk yield traits in Holstein and Jersey cattle raised in TurkeyRegulating glycolysis and heat shock proteins in Gannan yaks (Bos grunniens) in response to hypoxia of the Qinghai–Tibet PlateauVariation in bovine leptin gene affects milk fatty acid composition in New Zealand Holstein Friesian × Jersey dairy cowsDetection of genetic variation and activity analysis of the promoter region of the cattle tRNA-modified gene TRDMT1Regulation of microRNA-33, SREBP and ABCA1 genes in a mouse model of high cholesterolEffects of polymorphism of the GPAM gene on milk quality traits and its relation to triglyceride metabolism in bovine mammary epithelial cells of dairy cattleDetermination of the effect of functional single-nucleotide polymorphisms associated with glycerolipid synthesis on intramuscular fat deposition in Korean cattle steerDNA analysis of the Russian populations of Aberdeen Angus, Hereford and Belgian Blue cattleVariation in the stearoyl-CoA desaturase gene (SCD) and its influence on milk fatty acid composition in late-lactation dairy cattle grazed on pastureGenetic variant of SPARC gene and its association with growth traits in Chinese cattleEffect of DNA markers on the fertility traits of Japanese Black cattle for improving beef quantity and qualityThe effect of polymorphism in the FADS2 gene on the fatty acid composition of bovine milkPotential of TLR-gene diversity in Czech indigenous cattle for resistance breeding as revealed by hybrid sequencingExploring insertions and deletions (indels) of MSRB3 gene and their association with growth traits in four Chinese indigenous cattle breedsExploring genetic diversity and phylogenic relationships of Chinese cattle using gene mtDNA 16S rRNAThe effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytesCopy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traitsPolymorphisms of the ASIP gene and the haplotype are associated with fat deposition traits and fatty acid composition in Chinese Simmental steersComprehensive assessment of candidate genes associated with fattening performance in Holstein–Friesian bullsAssessment of growth hormone gene polymorphism effects on reproductive traits in Holstein dairy cattle in TunisiaEffects of polymorphisms in CAPN1 and CAST genes on meat tenderness of Chinese Simmental cattleEffect of leptin genetic polymorphism on lameness prevalence in Tunisian Holstein cowsThe microRNA gene bta-mir-2313 in cattle: an atlas of regulatory elements and an association analysis with growth and carcass traits in the Slovenian Simental cattle breedThe effect of short/branched chain acyl-coenzyme A dehydrogenase gene on triglyceride synthesis of bovine mammary epithelial cellsIdentification of a novel 24 bp insertion–deletion (indel) of the androgen receptor gene and its association with growth traits in four indigenous cattle breedsA combined genotype of three SNPs in the bovine gene is related to growth performance in Chinese cattleEvaluation of novel SNPs and haplotypes within the ATBF1 gene and their effects on economically important production traits in cattleIdentification and expression analysis of miR-144-5p and miR-130b-5p in dairy cattleSIRT1 gene polymorphisms associated with carcass traits in Luxi cattleThe 10 bp duplication insertion/deletion in the promoter region within paired box 7 gene is associated with growth traits in cattlePSAP gene variants and haplotypes reveal significant effects on carcass and meat quality traits in Chinese Simmental-cross cattleExploration of the exonic variations of the iPSC-related Nanog gene and their effects on phenotypic traits in cattleA novel 17 bp indel in the SMAD3 gene alters transcription level, contributing to phenotypic traits in Chinese cattleIndels within the bovine visfatin gene affect its mRNA expression in longissimus muscle and subcutaneous fat
Eymen Demir, Nina Moravčíková, Bahar Argun Karsli, Radovan Kasarda, Ibrahim Aytekin, Umit Bilginer, and Taki Karsli
Arch. Anim. Breed., 66, 31–40,Short summary
This study confirmed that mtDNA could make a significant contribution to cattle farming in both theory and practice. In theory, even if they were domesticated in different geographical areas, the patterns of crossbreeding between taurine and indicine were detected in Anatolian cattle at a low frequency. In practice, pedigree records could be revised in terms of admixture level and species-specific haplotypes of taurine and indicine by the farmers via molecular studies such as mtDNA.
Gökhan Gökçe and Mervan Bayraktar
Arch. Anim. Breed., 65, 301–308,Short summary
The study was conducted on Holstein calves to find the association between MOGAT1, MOGAT3/g.A229G, and MOGAT3/g.G1627A and growth traits. Association analysis showed a statistically significant difference between the MOGAT1 and body weight, body length, and chest circumference, MOGAT3/g.A229G with ADG and withers height, and MOGAT3/g.G1627A with body weight and body length (p < 0.05). The results confirmed that the MOGAT1, MOGAT3/g.A229G, and MOGAT3/g.G1627A locus are strong candidate genes.
Hamiye Ünal and Sinan Kopuzlu
Arch. Anim. Breed., 65, 129–134,Short summary
This study's aim is to investigate the polymorphism of Simmental cattle raised on a private farm in terms of the CSN3 gene locus from milk proteins by using the PCR-RFLP method and to reveal the distribution of genotype and allele frequencies of animals in terms of related gene locations. In addition, the relationship between genotypes and some performance characteristics is investigated.
Wonhee Lee, Insik Nam, Daehyun Kim, Kukdong Kim, and Yoonseok Lee
Arch. Anim. Breed., 65, 47–53,Short summary
The AS-PCR analyzes genotypes using two pairs of primer in basic equipment: a thermal cycler and an electrophoresis system. This research team analyzed three SNPs in 10 Korean cattle using the AS-PCR method. The result can be easily confirmed visually through the appearance of different amplification sizes depending on allele. Therefore, the use of the AS-PCR method will enable researchers to carry out genotyping analysis for SNPs without the use of sophisticated instrumentation and at low cost.
Ozden Cobanoglu, Ertugrul Kul, Eser K. Gurcan, Samet H. Abaci, and Soner Cankaya
Arch. Anim. Breed., 64, 417–424,Short summary
This study aimed to detect a potential association between GHR/AluI polymorphism and milk yield and milk composition traits in dairy cows raised in commercial herds using the PCR-RFLP assay. In conclusion, the GHR gene should be regarded as potential candidate genes in marker-assisted selection programs to improve the performance of milk and related traits in Turkey dairy cattle populations.
Yuliang Wen, Jiqing Wang, Xiu Liu, Shaobin Li, Jiang Hu, and Yuzhu Luo
Arch. Anim. Breed., 64, 345–353,Short summary
The regulation of glycolysis and heat shock proteins (HSPs) in Gannan yaks at different altitudes were determined. We found that HIF1A and PDK4 expression and glycolysis-related enzyme level were significantly increased, but CA level was significantly decreased with altitude. HSP27 and HSP60 were highly expressed with altitude. These results are useful to better understand the unique adaptability of Gannan yaks, allowing them to survive in hypoxia conditions.
Ishaku Lemu Haruna, Huitong Zhou, and Jon G. H. Hickford
Arch. Anim. Breed., 64, 245–256,Short summary
The polymerase chain reaction (PCR) coupled with single-strand conformational polymorphism (SSCP) analysis was used to reveal variation in bovine leptin gene (LEP) in New Zealand (NZ) Holstein Friesian × Jersey (HF × J) dairy cows. This is the first report of findings of this kind in NZ HF × J cows, and they suggest that variation in exon 3 of bovine leptin gene could be explored as a means of decreasing the concentration of saturated fatty acids in milk.
Xiaohua Yi, Shuai He, Shuhui Wang, Haidong Zhao, Mingli Wu, Shirong Liu, and Xiuzhu Sun
Arch. Anim. Breed., 64, 147–155,Short summary
In this experiment, by detecting the mutation in the promoter region of the bovine TRDMT1 gene, fluorescent recombinant plasmids of different genotypes were constructed at this site, and the relative fluorescence intensity was analyzed by detecting the transfected 293T cells. Our experiment detected a natural genetic variation of a tRNA modification gene TRDMT1, which may provide potential natural molecular materials for the study of tRNA modification.
Xianglun Zhang, Hongbo Zhao, Qingkai Sheng, Xiaomu Liu, Wei You, Haichao Lin, and Guifen Liu
Arch. Anim. Breed., 64, 103–108,
Haibin Yu, Yaolu Zhao, Ambreen Iqbal, Lixin Xia, Zitong Bai, Hao Sun, Xibi Fang, Runjun Yang, and Zhihui Zhao
Arch. Anim. Breed., 64, 35–44,Short summary
In this study, we examine the correlation between the expression of GPAM and adipogenesis in bovine mammary epithelial cells (bMECs). Additionally, three novel polymorphisms are identified within the bovine key functional domain of GPAM. GPAM plays a pivotal role in the regulation of phospholipid levels and cellular triacylglycerol, and its mutations could serve as a competent molecular marker that could be utilized for marker-assisted selection.
Hyeongrok Kim, Dong-Yep Oh, and Yoonseok Lee
Arch. Anim. Breed., 64, 27–33,Short summary
Intramuscular fat deposition in the longissimus dorsi muscle of Hanwoo is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM). This gene regulates triacylglycerol by gene expression. Thus, our research group has identified SNPs related to the regulation of glycerolipid synthesis in the 3′-UTR of GPAM and verified the function of SNPs affecting intramuscular fat deposition in Hanwoo.
Elena N. Konovalova, Olga S. Romanenkova, Valeria V. Volkova, and Olga V. Kostyunina
Arch. Anim. Breed., 63, 409–416,Short summary
This F94L MSTN polymorphism study demonstrates the high genetic potential of Aberdeen Angus and Belgian Blue cattle. The Aberdeen Angus populations have animal carriers of the AM, OS, DD and M1 genetic defects points. Animal carriers of HY and MSUD genetic defects were absent in the Hereford herds. These facts allow us to conclude that the breeding of the above breeds has great potential for improving meat cattle industry profitability under genetic defect control.
Yunhai Li, Huitong Zhou, Long Cheng, Jenny Zhao, and Jonathan Hickford
Arch. Anim. Breed., 63, 355–366,
Danyang Zhang, Jiawei Xu, Peng Yang, Yifan Wen, Hua He, Jiaxiao Li, Juntong Liang, Yining Zheng, Zijing Zhang, Xianwei Wang, Xiang Yu, Eryao Wang, Chuzhao Lei, Hong Chen, and Yongzhen Huang
Arch. Anim. Breed., 63, 31–37,
Fuki Kawaguchi, Miyako Tsuchimura, Kenji Oyama, Tamako Matsuhashi, Shin Maruyama, Hideyuki Mannen, and Shinji Sasazaki
Arch. Anim. Breed., 63, 9–17,
Witold Stanisław Proskura, Michał Liput, Daniel Zaborski, Zbigniew Sobek, Yu-Hsiang Yu, Yeong-Hsiang Cheng, and Andrzej Dybus
Arch. Anim. Breed., 62, 547–555,Short summary
Polyunsaturated fatty acids play an important role in a wide variety of physiological processes. They are produced by a series of chemical reactions. One of the enzymes converting such acids is a delta 6 desaturase encoded by the FADS2 gene. Therefore, we aimed to determine possible associations between the polymorphism in this gene and milk fatty acid composition in dairy cattle. An identified substitution could be used as a potential genetic marker for fatty acid composition in bovine milk.
Karel Novák, Marek Bjelka, Kalifa Samake, and Terezie Valčíková
Arch. Anim. Breed., 62, 477–490,Short summary
Resequencing of diversity hidden in the innate-immunity genes of the TLR series in Czech Simmental, its conserved subpopulation, and the ancestral Czech Red cattle showed sufficient potential for infection resistance breeding regardless of the prevailing breeding for production traits on the one hand and a limited potential of diversity preserved in the historical populations on the other. The importance of the characterization of genetic resources to counteract changing infections is implied.
Mingli Wu, Shipeng Li, Guoliang Zhang, Yingzhi Fan, Yuan Gao, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Yun Ma, and Ruihua Dang
Arch. Anim. Breed., 62, 465–475,Short summary
Four indels were identified by sequencing with DNA pool. Association analysis showed that three of them were associated with growth traits (P<0.05). Our results demonstrated that the polymorphisms in bovine MSRB3 gene were significantly associated with growth traits, which could be candidate loci for marker-assisted selection (MAS) in cattle breeding. These molecular markers are expected to accelerate the process of molecular breeding.
Linjun Yan, Yifan She, Mauricio A. Elzo, Chunlei Zhang, Xingtang Fang, and Hong Chen
Arch. Anim. Breed., 62, 325–333,Short summary
Most gene mtDNA 16S rRNA studies were with aquatic organisms, insects, and a few mammalian species; no reports involved cattle. The objective of this research was to characterize the genetic and phylogenetic diversity among 12 cattle breeds utilizing gene mtDNA 16S rRNA. The base percentages of this gene had a strong bias towards A + T. Only transitions or transversions were detected. The phylogenetic analysis indicated the existence of Bos taurus and Bos indicus ancestry in Chinese cattle.
Xiang Yu, Xibi Fang, Hang Xiao, Zhihui Zhao, Steffen Maak, Mengyan Wang, and Runjun Yang
Arch. Anim. Breed., 62, 257–264,Short summary
The study was to clarify the roles of ACSL5 in regulating synthesis of triglycerides and lipid droplet formation in bovine preadipocytes through vectors constructing and electransfection. Research results confirmed that the ACSL5 gene could promote the synthesis of triglycerides in bovine adipocytes by participating in the fatty acid metabolism pathway. The interaction of ACSL5 with related fatty acid synthase in the fatty acid biosynthesis pathway needs further analysis.
Yi-Lei Ma, Yi-Fan Wen, Xiu-Kai Cao, Jie Cheng, Yong-Zhen Huang, Yun Ma, Lin-Yong Hu, Chu-Zhao Lei, Xing-Lei Qi, Hui Cao, and Hong Chen
Arch. Anim. Breed., 62, 171–179,Short summary
We used lots of Chinese cattle to detect the specific regional variation in the IGF1R genome. It was found that this variation in the Chinese cattle population is related to the weight and height of the cattle. There is a lot of genetic information in this mutated region, which may be the cause affecting the traits. Our study provided a preliminary result for the functional role of the IGF1R variation in larger populations and for an important marker in cattle breeding programs.
Yinuo Liu, Xibi Fang, Zhihui Zhao, Junya Li, Elke Albrecht, Lisa Schering, Steffen Maak, and Runjun Yang
Arch. Anim. Breed., 62, 135–142,Short summary
ASIP can regulate the obesity of mice but studies of ASIP effects on bovine fat deposition and meat quality are rare. The L1-BT element inserted upstream of bovine ASIP can cause ASIP mRNA overexpression. In this study, L1-BT element indel, two single nucleide polymorphisms (SNPs) in ASIP, and its haplotypes showed significant correlations with fat deposition traits and fatty acid composition in Chinese Simmental steers, suggesting that ASIP may be a biomarker for beef cattle breeding selection.
Sena Ardicli, Hale Samli, Buse Vatansever, Bahadir Soyudal, Deniz Dincel, and Faruk Balci
Arch. Anim. Breed., 62, 9–32,Short summary
An extensive genetic evaluation of cattle fattening performance was performed in this study. Fifteen SNPs in the LEP, FABP4, DGAT1, TG, IGF1, IGF1R, MYF5, LGB, CAPN1, CAST, GHR, and OLR1 genes were evaluated in 296 purebred Holstein–Friesian bulls using PCR-RFLP. This study clearly demonstrated that individual or combined effects of the genotypes at the selected genes may be effective on performance traits at different periods of animal growth and fattening.
Sihem Amiri, Bayrem Jemmali, Mohamed Amine Ferchichi, Hajer Jeljeli, Rekik Boulbaba, and Abderrahmane Ben Gara
Arch. Anim. Breed., 61, 481–489,Short summary
Genetic polymorphims in the growth hormone (GH) gene were studied in 410 Holstein dairy cows. Genotyping was carried out using PCR-RFLP. Data were analyzed by the MIXED procedure to reveal the effect of GH genotypes on reproductive traits. GH-AluI had a favorable effect on exanimate traits except for the age at the first calving. The homozygous LL genotype seemed to be advantageous for calving interval and days open. A significant effect of different GH-AluI–MspI combined genotypes was found.
Xiaomei Sun, Xiuxiang Wu, Yongliang Fan, Yongjiang Mao, Dejun Ji, Bizhi Huang, and Zhangping Yang
Arch. Anim. Breed., 61, 433–439,Short summary
Genetic markers are important tools for beef cattle breeding. Our work suggests that CAPN1 genetic markers have a positive effect on meat tenderness and marbling traits, the most important meat quality traits for consumers. The associations between the genotyped SNPs in this research and meat quality traits are of potential interest to the beef industry and could lay an important foundation for the expanding panel of functional variation relevant to meat quality.
Mohamed Amine Ferchichi, Bayrem Jemmali, Sihem Amiri, Abderrahmane Ben Gara, and Boulbaba Rekik
Arch. Anim. Breed., 61, 305–310,Short summary
This study aims to investigate the screening of leptin genetic polymorphism and its effect on lameness prevalence. Prevalence of lameness was evaluated and results showed that genotypes and other factors included in the logistic regression model significantly affect the prevalence of lameness in Holstein cows (P < 0.01). The probability of lameness incidence varied between 37 % and 99 % with parity. This recorded incidence is greater in winter and autumn than in the summer and spring.
Špela Malovrh, Tanja Kunej, Milena Kovač, and Peter Dovč
Arch. Anim. Breed., 61, 271–278,Short summary
Effects of miRNA polymorphisms on phenotypic traits have been studied in several species but much less in cattle. We tested the association between polymorphisms of bta-miR-2313 and growth and carcass traits in the Slovenian Simmental cattle breed and developed an atlas of miRNA regulatory elements. Bta-miR-2313 warrants further functional analysis since it overlaps with several QTL, has over 3100 predicted targets, and is located within GRAMD1B, associated with production traits in cattle.
Ping Jiang, Xibi Fang, Zhihui Zhao, Xianzhong Yu, Boxing Sun, Haibin Yu, and Runjun Yang
Arch. Anim. Breed., 61, 115–122,Short summary
ACADSB is a member of the acyl-CoA dehydrogenase family, which can catalyze the dehydrogenation of acyl-CoA derivatives in lipometabolism. Our previous transcriptome analysis results identified it as a differentially expressed gene in mammary tissue between low and high milk fat cattle. Current results showed that ACADSB expression level was positively correlated with cellular triglycerides content, and it was actively involved in fatty acid metabolism pathway in BME cell of dairy cattle.
Haidong Zhao, Mingli Wu, Shuhui Wang, Xiaohui Yu, Ze Li, Ruihua Dang, and Xiuzhu Sun
Arch. Anim. Breed., 61, 71–78,Short summary
The androgen receptor (AR) plays the vital role of a bridge on the function of the androgen and has sexual size dimorphism. For this reason, the objective of this study was to explore the novel indel variants within the cattle AR gene and to detect a novel 24 bp indel within the AR gene. It significantly affected growth traits, suggesting that this indel may be a useful DNA marker for the elimination or selection of excellent individuals for cattle breeding.
Jieping Huang, Qiuzhi Zheng, Shuzhe Wang, Qiongqiong Zhang, Lijun Jiang, Ruijie Hao, Fen Li, and Yun Ma
Arch. Anim. Breed., 60, 357–362,Short summary
We investigated the expression profile and polymorphism of bovine PPARD as well as their association with growth traits in Chinese cattle. Association analysis suggested that individuals with the GAAGTT combined genotype of three SNPs detected showed optimal values in all the growth traits analyzed. These results revealed that the GAAGTT combined genotype of three SNPs detected in the bovine PPARD gene was a significant potential genetic marker for marker-assisted selection in Chinese cattle.
Han Xu, Sihuan Zhang, Xiaoyan Zhang, Ruihua Dang, Chuzhao Lei, Hong Chen, and Xianyong Lan
Arch. Anim. Breed., 60, 285–296,Short summary
This work identified SNPs in the growth- and development-related ATBF1 gene in cattle. Five novel SNPs were found in 644 cattle. The results found that SNP1, SNP2, and SNP3 and the combined genotypes SNP1–SNP3, SNP1–SNP4 and SNP2–SNP5 were significantly associated with growth traits in Qinchuan and Jinnan cattle. These findings indicate that the bovine ATBF1 gene has marked effects on growth traits, and the growth-trait-related loci can be used as DNA markers for MAS breeding programs in cattle.
Zhixiong Li, Hongliang Wang, Ling Chen, Mengxing Zhai, Si Chen, Na Li, and Xiaolin Liu
Arch. Anim. Breed., 60, 199–204,Short summary
Bovine mastitis, a prevalent and complex infectious disease, can result in significant dairy cattle losses. MicroRNAs (miRNAs) play important roles in regulating innate and adaptive immune responses. The results in this paper show that the expression of miR-144-5p and miR-130b-5p in mastitis-infected mammary tissue was significantly downregulated and upregulated, respectively, compared to healthy tissue. Our findings may provide a method for the treatment of mastitis.
Guifen Liu, Hongbo Zhao, Xiuwen Tan, Haijian Cheng, Wei You, Fachun Wan, Yifan Liu, Enliang Song, and Xiaomu Liu
Arch. Anim. Breed., 60, 27–32,Short summary
The main contribution of our paper is the identification of several SNPs of the SIRT1 gene in beef cattle and their relationships to carcass traits such as weight and meat percentage. We believe that this contribution is theoretically and practically relevant because beef cattle are bred to maximize carcass quality, but traits that lead to carcass quality are difficult to assess in vivo. We provide a method to select individuals for breeding based on genetic propensity for meat production.
Yunyun Jin, Hanfang Cai, Jiming Liu, Fengpeng Lin, Xinglei Qi, Yueyu Bai, Chuzhao Lei, Hong Chen, and Xianyong Lan
Arch. Anim. Breed., 59, 469–476,Short summary
Paired box 7 (Pax7) gene, a member of the paired box gene family, plays a critical role in animal growth and muscle development, especially in cell proliferation and self-renewal. In our study, the 10 bp duplication indel was detected in the promoter region within bovine Pax7 gene as well as its association with growth traits. This indel was significantly associated with the body weight in Xianan cattle, the body height in Jinjiang cattle, and the hip width in Pi'nan cattle.
Pengcheng Guo, Zhihui Zhao, Shouqing Yan, Junya Li, Hang Xiao, Dongxue Yang, Yaolu Zhao, Ping Jiang, and Runjun Yang
Arch. Anim. Breed., 59, 461–468,Short summary
Prosaposin (PSAP) is involved in muscle development and as a candidate gene in economic traits of cattle. Six novel SNPs of PSAP were identified and 47 traits in beef cattle measured. Association analysis revealed I10-65G > A, I10-162C > T, and E11-93C > G were significantly associated with carcass composition traits. Individuals with GCCCGC and ACCTCC haplotypes showed higher dressed weight, backfat thickness, and rib eye area, thus suggesting a genetic influence on cattle carcass composition.
Meng Zhang, Chuanying Pan, Qin Lin, Shenrong Hu, Ruihua Dang, Chuzhao Lei, Hong Chen, and Xianyong Lan
Arch. Anim. Breed., 59, 351–361,Short summary
Nanog is an important pluripotent transcription regulator, and its overexpression leads to a high expression of the growth and differentiation factor 3, affecting animal growth traits. The aim of this study was to explore the genetic variations within the Nanog gene and their effects on phenotypic traits in cattle. Six novel exonic single nucleotide polymorphisms were found in six cattle breeds and indicated that Nanog could be a candidate gene for marker-assisted selection in cattle breeding.
Tao Shi, Wenwen Peng, Jianyu Yan, Hanfang Cai, Xianyong Lan, Chuzhao Lei, Yueyu Bai, and Hong Chen
Arch. Anim. Breed., 59, 151–157,Short summary
SMAD3 plays essential roles in myogenesis and osteogenesis and may relate to the regulation of body weight. In this study, a 17 bp indel in intron3 of the SMAD3 gene was detected in four Chinese cattle breeds (Qinchuan, Jiaxian, Nanyang and Caoyuan) by using DNA pool sequencing, and it was significantly associated with gene expression and growth traits of Qinchuan and Caoyuan cattle. This indel could be could be a promising marker for beef cattle breeding.
H. Cai, Z. Wang, X. Lan, Y. Xu, H. Chen, and C. Lei
Arch. Anim. Breed., 59, 91–95,Short summary
In this research, the effects of two indel loci of the visfatin gene on mRNA expression levels were studied. The results imply that the expression levels of bovine visfatin vary with age and its indels might be putative variants mediating the expression of the bovine visfatin gene. This study provides useful information for further functional studies of bovine visfatin.
Akyüz, B. and Çınar, M. U.: Analysis of prolactin and kappa-casein genes polymorphism in four cattle breeds in Turkey, Ann. Anim. Sci., 14, 799–806, https://doi.org/10.2478/aoas-2014-0036, 2014.
Akyüz, B., Arslan K., Bayram, D., and İşcan, K. M.: Allelic frequency of kappa-casein, growth hormone and prolactin gene in Holstein, Brown Swiss and Simmental cattle breeds in Turkey, Kafkas Univ. Vet. Fak., 19, 439–444, https://doi.org/10.9775/kvfd.2012.7985, 2013.
Aytekin, I. and Boztepe, S.: Associations of Pit-1 gene polymorphism with milk yield and composition traits in brown swiss cattle, J. Anim. Plant Sci., 23, 1281–1289, 2013.
Bayram, D., Arslan, K., Akyuz, B., and Iscan, K. M.: Identification of pituitary-specific transcription factor-1 (PIT-1) and leptin gene (LEP) polymorphism of Holstein cattle reared in Turkey, Ankara Üniv. Vet. Fak., 64, 337–343, https://doi.org/10.1501/Vetfak_0000002818, 2017.
Caroli, A. M., Chessa, S., and Erhardt, G. J.: Milk protein polymorphisms in cattle: effect on animal breeding and human nutrition, J. Dairy Sci., 92, 5335–5352, https://doi.org/10.3168/jds.2009-2461, 2009.
Cohen, L. E., Wondisford, F. E., and Radovick, S.: Role of Pit-I in the gene expression of growth hormone, prolactin, and thyrotropin, Endocrin. Metab. Clin. North Am. 25, 523–540, https://doi.org/10.1016/s0889-8529(05)70339-x, 1996.
Cosier, V.: RFLP/HinfI polymorphism between exon 5 and exon 6 of the Pit-1 gene in Romanian Simmental cattle. Buletinul Universitatii de Stiinte Agricole si Medicina Veterinara Cluj-Napoca, Seria Zootehnie si Biotehnologii, România, https://doi.org/10.15835/buasvmcn-agr:11145, 2006.
Curi, R. A., Palmieri, D. A., Suguisawa, L., de Oliviera, H. N., Silveira, A. C., and Lopes, C. R.: Growth and carcass traits associated with GH1/AluI and POU1F1/HinfI gene polymorphisms in Zebu and crossbred beef cattle, Gen. Mol. Biol., 29, 56–61, https://doi.org/10.1590/S1415-47572006000100012, 2006.
Dario, C., Selvaggi, M., Carnicella, D., and Bufano, G.: STAT5A/Aval polymorphism in Podolica bulls and its effect on growth performance traits, Livest Sci., 123, 83–87, https://doi.org/10.1016/j.livsci.2008.10.011, 2009.
Demirel, F.: Siyah Alaca Sığırlarda Alfa-Kazein, Beta-Kazein Ve Kappa-Kazein Gen Polimorfizminin Süt Verimi ve Süt Bileşenlerine Etkisinin Pcr-Rflp Yöntemiyle Araştırılması, Doktora Tezi, Sağlık Bilimler Enstitüsü [Investigation of the effect of alpha-casein, beta-casein and kappa-casein gene polymorphism on milk production and milk component in holstein cattle with PCR-RFLP method, PhD thesis, Van], Zootekni Anabilim Dalı, Van Yüzüncü Yıl Üniversitesi, Van, 2019 (in Turkish).
Di Stasio, L., Sartore, S., and Albera, A.: Lack of association of GH1 and POU1F1 gene variants with meat production traits in Piemontese cattle, Anim. Genet., 33, 61–64, https://doi.org/10.1046/j.1365-2052.2002.00811.x, 2002.
Doğru, U., Özdemir, M., and Ercisli, S.: Genetic polymorphism in Kappa-casein gene detected by PCR-RFLP in cattle, J. Appl. Anim. Res., 33, 65–68, https://doi.org/10.1080/09712119.2008.9706898, 2008.
Dybus, A., Kmieć, M., Sobek, Z., Pietrzyk, W., and Wiśniewski, B.: Associations between polymorphisms of growth hormone releasing hormone (GHRH) and pituitary transcription factor 1 (PIT1) genes and production traits of Limousine cattle, Arch. Anim. Breed., 46, 527–534, https://doi.org/10.5194/aab-46-527-2003, 2003.
Dybus, A., Zatkowska, I., Czerniawska-Piatkowska, E., Grzesiak, W., Wojcik, J., Edyta, R., and Zych, S.: PIT1-HinfI gene polymorphism and its associations with milk production traits in polish Black-and-White cattle, Arch. Tierzucht, 47, 557–563, https://doi.org/10.5194/aab-47-557-2004, 2004.
Erhardt, G. and Weimann, C.: Use of molecular markers for evaluation of genetic diversity and in animal production, Archivos Latinoamericanos de Producción Animal, 15, 63–66, 2007.
Feligini, M., Vlaco, S., Curik, V., Parma, P., Greppi, G., and Enne, G.: A single nucleotide polymorphism in the sheep κ-casein coding region, J. Dairy Res., 72, 317–321, https://doi.org/10.1017/S0022029905000932, 2005.
Gedik, Y.: Türkiye'de Yetiştirilen BazıSiyah Alaca Sığır Populasyonlarında Beta-Laktoglobulin ve Kappa-Kazein Genotiplerinin PCR-RFLP Yöntemi Kullanılarak Belirlenmesi [Identification of beta-lactoglobulin and kappa-casein genotyping using PCR-RFLP in some Holstein cattle breed populatıons in Turkey, Master thesis, Ankara], Ankara Üniversitesi, Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, Ankara, http://hdl.handle.net/20.500.12575/30500 (last access: 21 June 2022), 2009 (in Turkish).
Gürcan, K.: Siyah Alaca Süt Sığırlarında Çeşitli Süt ve Kan Protein Polimorfizmi ve Bu Özelliklerle Bazı Verim Özellikleri Arasındaki İlişkiler. Doktora Tezi, Fen Bilimleri Enstitüsü, Trakya Üniversitesi, Tekirdağ, Ulusal Tez Merkezi, https://yok.gov.tr (last access: 21 June 2022), 2001 (in Turkish).
Heidari, M., Azari, M. A., Hasani, S., Khanahmadi, A., and Zerehdaran, S.: Effect of polymorphic variants of GH, Pit-1, and β-LG genes on milk production of Holstein cows, Russ. J. Genet., 48, 417–421, https://doi.org/10.1134/S1022795412040060, 2012.
Hetzel, J.: Delivery of gene marker technology to the beef industry. The John M. Airy Beef Cattle Symposium, Visions for genetics and breeding, 15–17 May 2003, Iowa State University, CAB International, AgBiotechNet Proceedings, 4, 1–4, 2004.
Hu, C. C. and Mao, F. C.: Kappa-casein genotyping and its correlation with milk producing ability of Holstein bulls, Taiwan journal of Veterinary Medicine and Animal Husbundary, 65, 247–254, 1995.
Hua, G. H., Chen, S. L., Yu, J. N., Cai, K. L., Wu, C. J., Li, Q. L., Zhang, C. Y., Liang, A. X., Han, L., Geng, L. Y., Shen, Z., Xu, D. Q., and Yang, L. G.: Polymorphism of the growth hormone gene and its association with growth traits in Boer goat bucks, Meat Sci., 81, 391–395, https://doi.org/10.1016/j.meatsci.2008.08.015, 2009.
Jia, B., Zheng, X. C., Chen, H. Y., and Zhao, Z. S.: Identification of SNP within the sheep PROP 1 gene and their effects on wool traits, Mol. Biol., 38, 2723–2728, 2011.
Kaminski, S.: Bovine kappa-casein (CASK) gene-molecular nature and application in dairy cattle breeding, J Appl. Genet., 37, 176–196, 1996.
Khaizaran, Z. A. and Al-Razem, F.: Analysis of selected milk traits in Palestinian Holstein- Friesian cattle in relation to genetic polymorphism, Journal of Cell and Animal Biology, 8, 74–85, https://doi.org/10.5897/jcab2014.0409, 2014.
Litwinczuk, Z. and Krol, J.: Polymorphism of main milk proteins in beef cattle maintained in East-Central Poland, Anim. Sci. Pap. Rep., 1, 33–40, 2002.
Lunden, A., Nilsson, M., and Janson, L.: Marked effect of β-lactoglobulin polymorphism on the ratio of casein to total protein in milk, J. Dairy Sci., 80, 2996–3005, https://doi.org/10.3168/jds.S0022-0302(97)76266-0, 1997.
Nasr, M., Awad, A., and El-Araby, I.: Associations of leptin and pituitary-specific transcription factor genes polymorphisms with reproduction and production traits in dairy buffalo, Reprod. Domest. Anim., 51, 597–603, https://doi.org/10.1111/rda.12726, 2016.
Oprzadek, J., Flisikowski K., Zwierzchowski, L., and Dymnicki, E.: Polymorphisms at loci of Leptin (LEP), Pit1 and STAT5A and their association with growth, feed conversion and carcass quality in Black-and White bulls, Anim. Sci. Pap. Rep., 21, 135–145, 2003.
Othman, O. E., Zayed, F. A., El-Gawead, A. A., and El-Rahman, M. R. A.: Genetic polymorphism of three genes associated with milk trait in Egyptian buffalo, Journal of Genetic Engineering and Biotechnology, 9, 97–102, https://doi.org/10.1016/j.jgeb.2011.09.002, 2011.
Özdemir, M.: Determination of Pit-1/Hinf1 polymorphism in Holstein and Native Ear cattle raised as genetic resource in Turkey, J. Anim. Plant Sci., 22, 25–28, 2012.
Özdemir, M. and Doğru, Ü.: Relationship between kappa-casein polymorphism and production traits in brown swiss and holstein, J. Appl. Anim. Res., 27, 101–104, https://doi.org/10.1080/09712119.2005.9706549, 2005.
Özdemir, M. and Doğru, Ü.: Sığırların Verim Özellikleri Üzerine Etkili Önemli Moleküler Markörler, Atatürk Üniv. Ziraat Fak. Derg, 39, 127–135, Sığırların Verim Özellikleri Üzerine Etkili Önemli Moleküler Markörler, https://acarindex.com (last access: 21 June 2022), 2008 (in Turkish).
Özdemir, M., Topal, M., and Vecihi, A.: The relationships between performance traits and the bGH/Alu I and Pit-1/Hinf I polymorphisms in Holstein cows, Indian J. Anim. Res., 52, 186–191, https://doi.org/10.18805/ijar.v0iOF.8495, 2018.
Peel, C. J. and Bauman, D. E.: Somatotropin and lactation, J. Dairy Sci., 70, 474–486, https://doi.org/10.3168/jds.S0022-0302(87)80030-9, 1987.
Pfäffle, R. W., Dimattia, G. E., Parks, J. S., Brown, M. R., Wit, J. M., Jansen, M., Van Der Nat, H., Van Den Brandem J. L., Rosenfeld, M. G., and Ingraham, H. A.: Mutation of the Pou-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia, Science, 257, 1118–1121, https://doi.org/10.1126/science.257.5073.1118, 1992.
Pytlewski, J., Antkowiak, I., and Czerniawska-Piątkowska, E.: Relationship of PIT-1 gene polymorphism with breeding parameters and body weights of cows and calves, Pak. J. Zool., 50, 183–187, https://doi.org/10.17582/journal.pjz/2018.50.1.183.187, 2018.
Raymond, M. and Rousset, F.: GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism, J. Hered., 86, 248–249, https://doi.org/10.1093/oxfordjournals.jhered.a111573, 1995.
Ren, D. X., Miao, S. Y., Chen, Y. L., Zou, C. X., Liang, X. W., and Liu J. X.: Genotyping of the k-casein and β-lactoglobulin genes in Chinese Holstein, Jersey and water buffalo by PCR-RFLP, J. Genet., 19, 1–5, 2011.
Renaville, R., Gengler, E., Vrech, A., Prandi, S., Massart, S., Corradini, C., Bertozzi, C. F., and Mortiaux-Burny, P.: Pit-1 Gene Polymorphism, Milk Yield, and Conformation Traits for Italian Holstein-Friesian Bulls Author links open overlay panel, J. Dairy Sci., 80, 3431–3438, https://doi.org/10.3168/jds.S0022-0302(97)76319-7, 1997.
Strzalkowska, N., Krzyzewski, J., Zwierzchowski, L., and Ryniewicz, Z.: Effects of κ-casein and β-lactoglobulin loci polymorphism, cows'age, stage of lactation and somatic cell count on daily milk yield and milk composition in Polish Black-and-White cattle, Anim. Sci. P., 20, 21–35, 2002.
Thuy, N. T. D., Thu, N. T., Cuong, N. H., Ty, L. V., Nguyen, T. T. B., and Khoa, D. V. A.: Polymorphism of PIT-1 and Prolactin Genes and Their Effects on Milk Yield in Holstein Frisian Dairy Cows Bred in Vietnam, Russ. J. Genet., 54, 346–352, https://doi.org/10.1134/S1022795418030146, 2018.
Trakovicka, A., Moravcikova, N., Minaroviç, T., and Navratilova, T.: SNPs analyses of the bovine LEP and PIT-1 genes by multiplex PCR-RFLP method and their effect on milk performance traits in Slovak Simmental cattle, Journal of Central European Agriculture, 16, 65–75, https://doi.org/10.5513/JCEA01/16.1.1542, 2015.
Ünal, H. and Kopuzlu, S.: The relationships between κ-casein (CSN3) gene polymorphism and some performance traits in Simmental cattle, Arch. Anim. Breed., 65, 129–134, https://doi.org/10.5194/aab-65-129-2022, 2022.
Unanian, M. M., Barreto, C. C., Cordeiro, C. M. T., Freitas, A. R., Josahkian, L. A.: Possible associations between bovine growth hormone gene polymorphism and reproductive traits, Braz. Arch. Biol. Techn., 45, 293–299, https://doi.org/10.1590/S1516-89132002000300007, 2002.
Viorica, C.: RLFP\HınfI Polymorphısms Between Exons 5 and Exon 6 of the Pıt-1 gene in Romanian Simmental Cattle, USAMV Journal, 63, 219–222, 2006.
Vlaic, A., Pamfil, D. C., Gaboreanu, I., Vlaic, B., and Renaville, R.: Increasing milk production in cattle using DNA marker assisted selection (Pit-1), Buletinul Universitatii de Stiinte Agricole si Medicina Veterinara Cluj-Napoca, Seria Zootehnie si Biotehnologii, 59, 188–191, 2003.
Vlaic, A., Coiser, V., and Gaboreanu, I.: Hinf/1 Polymorphisms of K-Casein and Pit-1 genes in Romanian Simmental Cattle, University of Agriculture Sciences and Veterinary Medicine Cluj-Romania, 40, 551–556, 2007.
Xue, K., Chen, H., Wang, S., Cai, X., Liu, B., Zhang, C.-F., Lei, C. Z., Wang, X.-Z., Wang, Y.-M., and Niu, H.: Effect of genetic variations of the POU1F1 gene on growth traits of Nanyang cattle, Acta Genetica Sinica, 33, 901–907, https://doi.org/10.1016/S0379-4172(06)60124-8, 2006.
Zhang, C., Liu, B., Chen, H., Lan, X., Lei, C., Zhang, Z., and Zhang, R.: Associations of a HinfI PCR-RFLP of POU1F1 gene with growth traits in Qinchuan cattle, Anim. Biotechnol., 20, 71–74, https://doi.org/10.1080/10495390802640462, 2009.
Zhang, L., Liu, J., Zhao, F., Ren, H., Xu, L., Lu, J., Zhang, S., Zhang, X., Wei, C., Lu, G., Zheng, Y., and Du, L.: Genome-wide association studies for growth and meat production traits in sheep, PloS One, 8, e66569, https://doi.org/10.1371/journal.pone.0066569, 2013.
Zhao, Q., Davis, M. E., and Hines, H. C.: Associations of polymorphisms in the Pit-1 gene with growth and carcass traits in Angus beef cattle, J. Anim. Sci., 82, 2229–2233, https://doi.org/10.2527/2004.8282229x, 2004.
Zwierzchowski, L., Kizyzeewski, J., Strzalkowska, N., Siadkowska, E., and Ryniewcz, Z.: Effects of polymorphism of growth hormone (GH), Pit-1, and leptin (LEP) genes, cow's age, lactation stage and somatic cell count on milk yield and composition, Anim. Sci. P., 20, 213–227, 2002.
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HinfI polymorphisms of Pit-1 and CSN3 genes were identified in DNA isolated from blood samples of 100 Holstein calves used in the study, using the PCR-RFLP method. According to the Hardy–Weinberg genetic equilibrium test, it was observed that the distribution of genotype frequencies of HinfI polymorphisms of Pit-1 genes in the studied population was in equilibrium, but not in equilibrium in terms of CSN3 gene location.
HinfI polymorphisms of Pit-1 and CSN3 genes were identified in DNA isolated from blood samples...