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In this study, we found that 21 mutation loci and 3 haplotypes were significantly associated with litter size in Nubian goat. This would allow breeders to take more precise selection decisions, leading to significantly higher productivity and profitability within the Nubian goat.
AAB | Articles | Volume 64, issue 2
Arch. Anim. Breed., 64, 375–386, 2021
https://doi.org/10.5194/aab-64-375-2021
Arch. Anim. Breed., 64, 375–386, 2021
https://doi.org/10.5194/aab-64-375-2021

Original study 17 Sep 2021

Original study | 17 Sep 2021

Population validation of reproductive gene mutation loci and association with the litter size in Nubian goat

Sanbao Zhang et al.

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Cited articles

An, X. P., Hou, J. X., Li, G., Song, Y. X., Wang, J. G., Chen, Q. J., Cui, Y. H., Wang, Y. F., and Cao, B. Y. J. A. G.: Polymorphism identification in the goat KITLG gene and association analysis with litter size, Anim. Genet., 43, 104–107, 2012. 
An, X. P., Bai, L., Hou, J., Zhao, H., Peng, J., Song, Y., Wang, J., and Cao, B.: Molecular cloning, tissue expression and SNP analysis in the goat nerve growth factor gene, Mol. Biol. Rep., 40, 857–863, https://doi.org/10.1007/s11033-012-2126-6, 2013a. 
An, X. P., Hou, J. X., Zhao, H. B., Li, G., Bai, L., Peng, J. Y., Q, M. Y., Song, Y. X., Wang, J. G., and Cao, B. Y.: Polymorphism identification in goat GNRH1 and GDF9 genes and their association analysis with litter size, Anim. Genet., 44, 234–238, https://doi.org/10.1111/j.1365-2052.2012.02394.x, 2013b. 
An, X. P., Han, P., Hou, J. X., Zhao, H. B., Yan, Y., Ma, T., Fang, F., Meng, F. X., Song, Y. X., Wang, J. G., and Cao, B. Y.: Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat, Genet. Mol. Res., 12, 4308–4316, https://doi.org/10.4238/2013.February.28.13, 2013c. 
An, X. P., Hou, J., Gao, T., Lei, Y., Li, G., Song, Y., Wang, J., and Cao, B.: Single-nucleotide polymorphisms g.151435C>T and g.173057T>C in PRLR gene regulated by bta-miR-302a are associated with litter size in goats, Theriogenology, 83, 1477–1483, 10.1016/j.theriogenology.2015.01.030, 2015a. 
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Short summary
In this study, we found that 21 mutation loci and 3 haplotypes were significantly associated with litter size in Nubian goat. This would allow breeders to take more precise selection decisions, leading to significantly higher productivity and profitability within the Nubian goat.
Citation