Articles | Volume 63, issue 2
Arch. Anim. Breed., 63, 241–248, 2020
https://doi.org/10.5194/aab-63-241-2020
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Arch. Anim. Breed., 63, 241–248, 2020
https://doi.org/10.5194/aab-63-241-2020
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original study 22 Jul 2020
Original study | 22 Jul 2020
Identification of novel nucleotide sequence variations in an extended region of the bovine leptin gene (LEP) across a variety of cattle breeds from New Zealand and Nigeria
Ishaku L. Haruna et al.
Related authors
Ishaku Lemu Haruna, Huitong Zhou, and Jon G. H. Hickford
Arch. Anim. Breed., 64, 245–256, https://doi.org/10.5194/aab-64-245-2021, https://doi.org/10.5194/aab-64-245-2021, 2021
Short summary
Short summary
The polymerase chain reaction (PCR) coupled with single-strand conformational polymorphism (SSCP) analysis was used to reveal variation in bovine leptin gene (LEP) in New Zealand (NZ) Holstein Friesian × Jersey (HF × J) dairy cows. This is the first report of findings of this kind in NZ HF × J cows, and they suggest that variation in exon 3 of bovine leptin gene could be explored as a means of decreasing the concentration of saturated fatty acids in milk.
Ishaku Lemu Haruna, Huitong Zhou, and Jon G. H. Hickford
Arch. Anim. Breed., 64, 245–256, https://doi.org/10.5194/aab-64-245-2021, https://doi.org/10.5194/aab-64-245-2021, 2021
Short summary
Short summary
The polymerase chain reaction (PCR) coupled with single-strand conformational polymorphism (SSCP) analysis was used to reveal variation in bovine leptin gene (LEP) in New Zealand (NZ) Holstein Friesian × Jersey (HF × J) dairy cows. This is the first report of findings of this kind in NZ HF × J cows, and they suggest that variation in exon 3 of bovine leptin gene could be explored as a means of decreasing the concentration of saturated fatty acids in milk.
Yunhai Li, Huitong Zhou, Long Cheng, Jenny Zhao, and Jonathan Hickford
Arch. Anim. Breed., 63, 355–366, https://doi.org/10.5194/aab-63-355-2020, https://doi.org/10.5194/aab-63-355-2020, 2020
Wenhao Li, Hua Gong, Huitong Zhou, Jiqing Wang, Shaobin Li, Xiu Liu, Yuzhu Luo, and Jon G. H. Hickford
Arch. Anim. Breed., 62, 509–515, https://doi.org/10.5194/aab-62-509-2019, https://doi.org/10.5194/aab-62-509-2019, 2019
Adel H. M. Ibrahim, Nikolaos Tzanidakis, Smaragda Sotiraki, Huitong Zhou, and Jonathan G. H. Hickford
Arch. Anim. Breed., 62, 413–422, https://doi.org/10.5194/aab-62-413-2019, https://doi.org/10.5194/aab-62-413-2019, 2019
Short summary
Short summary
Selective breeding for milk production traits in sheep using molecular marker technology offers a possibility of selecting accurately elite ewes and rams for milk production traits at early age. Our findings suggest that ovine FABP4 has a role in the variation of the milk production traits which may be of economic importance to sheep farmers. Variation in this gene could potentially be used as gene markers for milk production traits if such associations exist.
Related subject area
Subject: Quantitative genetics and estimation of breeding value | Animal: Cattle
The effect of single-nucleotide polymorphisms within heat shock protein beta 1 on beef quantity in Korean native steers
Determination of genetic variation within the DYRK2 gene and its associations with milk traits in cattle
Analysis of lactating cows on commercial Austrian dairy farms: the influence of genotype and body weight on efficiency parameters
Linking first lactation survival to milk yield and components and lactation persistency in Tunisian Holstein cows
Determination of a possible relationship between a single nucleotide polymorphism (SNP) in the promoter region of the SIRT1 gene and production and reproduction traits in the Agerolese cattle breed
(Co)variance components and genetics parameter estimation for linear traits in Holstein cattle in Indonesia: traits related to foot/leg and udder
Body weight prediction using body size measurements in Fleckvieh, Holstein, and Brown Swiss dairy cows in lactation and dry periods
Genetic parameters for longitudinal behavior and health indicator traits generated in automatic milking systems
Q method to map the diversity of stakeholder viewpoints along agricultural innovation systems: a case study on cattle genetic improvement in Niger
Invited review: Genetic and genomic mouse models for livestock research
Invited review: Reproductive and genomic technologies to optimize breeding strategies for genetic progress in dairy cattle
Individual and combined effects of CAPN1, CAST, LEP and GHR gene polymorphisms on carcass characteristics and meat quality in Holstein bulls
Effects of polymorphisms at LEP, CAST, CAPN1, GHR, FABP4 and DGAT1 genes on fattening performance and carcass traits in Simmental bulls
Genetic analysis of productive life length in Holstein dairy cows using Weibull proportional risk model
Genetic relationship of lactation persistency with milk yield, somatic cell score, reproductive traits, and longevity in Slovak Holstein cattle
AGPAT6 gene EX1_303T > C and EX12_299G > A mutations and associations with economic traits of Chinese Simmental-cross cattle
Estimation of variance components of milk, fat, and protein yields of Tunisian Holstein dairy cattle using Bayesian and REML methods
Genetic parameters of reproductive traits in Tunisian Holsteins
Comparison of breeding values among cows with exceptional longevity and their contemporary herdmates in German Holsteins
Jung-Keun Suh, Jae-Sung Lee, Hongsik Kong, Yoonseok Lee, and Hong-Gu Lee
Arch. Anim. Breed., 63, 417–422, https://doi.org/10.5194/aab-63-417-2020, https://doi.org/10.5194/aab-63-417-2020, 2020
Short summary
Short summary
The relationship between HSPB1 expression and muscle growth in beef cattle has previously been reported, but there have been no reports of DNA markers related to meat quantity in Korean native steers. Therefore, the aim of this study was to evaluate the relationship of SNPs within HSPB1 in terms of the carcass traits related to muscle growth in Korean native steers.
Cui Mao, Xing Ju, Haijian Cheng, Xixia Huang, Fugui Jiang, Yuni Yao, Xianyong Lan, and Enliang Song
Arch. Anim. Breed., 63, 315–323, https://doi.org/10.5194/aab-63-315-2020, https://doi.org/10.5194/aab-63-315-2020, 2020
Short summary
Short summary
To speed up the progress of marker-assisted selection (MAS) in cattle breeding, kinesin family member 1A (KIF1A) genes were chosen based on our previous genome-wide association study (GWAS) analysis results. We detected insertion/deletion (InDel) variation in these three candidate genes in 438 individual cattle (Xinjiang Brown cattle and Wagyu × Luxi crossbreed cattle). These findings may aid future analyses of InDel genotypes in cattle breeds and speed up the progress of MAS in cattle breeding.
Maria Ledinek, Leonhard Gruber, Franz Steininger, Birgit Fuerst-Waltl, Karl Zottl, Martin Royer, Kurt Krimberger, Martin Mayerhofer, and Christa Egger-Danner
Arch. Anim. Breed., 62, 491–500, https://doi.org/10.5194/aab-62-491-2019, https://doi.org/10.5194/aab-62-491-2019, 2019
Short summary
Short summary
The aim of this study was to evaluate the influence of body weight on the efficiency of dairy cows. Data were derived from 161 commercial Austrian dairy farms. An optimum body weight range for efficiency does exist as the relationship of milk yield and body weight is nonlinear. Specialized dairy breeds seem to respond more intensively to body weight range than dual-purpose breeds. Cows with medium weights are the most efficient. A further increase in dairy cows’ body weights should be avoided.
Marwa Grayaa, Sylvie Vanderick, Boulbaba Rekik, Abderrahman Ben Gara, Christian Hanzen, Siwar Grayaa, Rodrigo Reis Mota, Hedi Hammami, and Nicolas Gengler
Arch. Anim. Breed., 62, 153–160, https://doi.org/10.5194/aab-62-153-2019, https://doi.org/10.5194/aab-62-153-2019, 2019
Short summary
Short summary
The lactation curve and lactation survival are important in dairy cattle breeding. Their simultaneous improvement results in economic benefits. The genetic relationship between the lactation survival and the lactation curve shape traits of milk yield and fat and protein percentages using information from of 25 981 primiparous Tunisian Holsteins was investigated. Cows that had higher persistencies for fat and protein percentages were more likely not to survive.
Maria Selvaggi, Claudia Carbonara, Francesca Ciotola, Sara Albarella, Giulio Aiudi, Vincenzo Tufarelli, and Cataldo Dario
Arch. Anim. Breed., 62, 107–112, https://doi.org/10.5194/aab-62-107-2019, https://doi.org/10.5194/aab-62-107-2019, 2019
Short summary
Short summary
The aims of the study were to estimate allele and genotype frequencies at g.-274C > G locus in the promoter region of the SIRT1 gene and to investigate, for the first time, the relationship among different genotypes and milk and reproduction traits in the Agerolese cattle breed. The investigated population was found to be polymorphic at the investigated locus. Concerning milk production performance, significant differences between genotypes were found.
Agus Susanto, Suyadi, Veronica Margareta Ani Nurgiartiningsih, and Luqman Hakim
Arch. Anim. Breed., 61, 491–496, https://doi.org/10.5194/aab-61-491-2018, https://doi.org/10.5194/aab-61-491-2018, 2018
Short summary
Short summary
Improved milk yield in dairy cows results in worsening health and reproduction. Some linear traits are genetically associated with health and reproduction and can be used to assist selection programs. The National Breeding Centre for Dairy and Forage of Indonesia has not included linear traits in the breeding program. This study estimates genetic parameters of linear traits. The traits under study were found to be heritable and can be included in the breeding program along with milk yield.
Leonhard Gruber, Maria Ledinek, Franz Steininger, Birgit Fuerst-Waltl, Karl Zottl, Martin Royer, Kurt Krimberger, Martin Mayerhofer, and Christa Egger-Danner
Arch. Anim. Breed., 61, 413–424, https://doi.org/10.5194/aab-61-413-2018, https://doi.org/10.5194/aab-61-413-2018, 2018
Short summary
Short summary
The objective of this study was to predict dairy cows' body weight from body size measurements. Body weight is an important trait for both management and breeding. Data were derived from 167 commercial Austrian dairy farms. To ensure high prediction accuracy, the use of a combination of both heart girth and belly girth is recommended if the use of scales is impossible. The large and heterogeneous data set supported a valid prediction.
Laura Viviana Santos, Kerstin Brügemann, Asja Ebinghaus, and Sven König
Arch. Anim. Breed., 61, 161–171, https://doi.org/10.5194/aab-61-161-2018, https://doi.org/10.5194/aab-61-161-2018, 2018
Short summary
Short summary
The impact of the milking technique on the individual animal and the reaction of the animal on the technique were investigated. With the use of objectively recorded data from automatic milking systems (AMSs), auxiliary traits that reflect animal behavior in the milking system were defined, free from subjective impressions of classifiers. There is an apparent possibility to breed cows for AMS systems based on AMS data, though it is imperative to have further validation based on larger datasets.
Seyni Siddo, Nassim Moula, Issa Hamadou, Moumouni Issa, Salissou Issa, Marichatou Hamani, Pascal Leroy, and Nicolas Antoine-Moussiaux
Arch. Anim. Breed., 61, 143–151, https://doi.org/10.5194/aab-61-143-2018, https://doi.org/10.5194/aab-61-143-2018, 2018
Short summary
Short summary
The complex balance between innovation and conservation regarding animal genetic resources makes it difficult to find mutually accepted improvement pathways between breeders, government agencies, and research and education institutions. This study maps stakeholder viewpoints on cattle genetic improvement in Niger using the Q method, which appears effective in identifying the concerns of stakeholders on complex agricultural innovation topics.
Danny Arends, Deike Hesse, and Gudrun A. Brockmann
Arch. Anim. Breed., 61, 87–98, https://doi.org/10.5194/aab-61-87-2018, https://doi.org/10.5194/aab-61-87-2018, 2018
Short summary
Short summary
In this invited review we discuss the value of mice in improving livestock breeding. This review gives an overview of currently available databases for mice that can be used in livestock genetics research. Furthermore, this paper describes how different mouse models have contributed to livestock research in the past.
Allison Fleming, Emhimad A. Abdalla, Christian Maltecca, and Christine F. Baes
Arch. Anim. Breed., 61, 43–57, https://doi.org/10.5194/aab-61-43-2018, https://doi.org/10.5194/aab-61-43-2018, 2018
Short summary
Short summary
Dairy cattle breeders have exploited technological advances in regard to reproduction and genomics. The implementation of such technologies in routine breeding programs has permitted genetic gains in traditional milk production traits as well as, more recently, in low heritability traits like health and fertility. Here we review a number of technologies that have helped shape dairy breeding programs in the past and present, along with those potentially forthcoming.
Sena Ardicli, Hale Samli, Deniz Dincel, Bahadir Soyudal, and Faruk Balci
Arch. Anim. Breed., 60, 303–313, https://doi.org/10.5194/aab-60-303-2017, https://doi.org/10.5194/aab-60-303-2017, 2017
Short summary
Short summary
The impact of polymorphisms of the calpain 1 (CAPN1), calpastatin (CAST), leptin (LEP) and growth hormone receptor (GHR) on carcass characteristics and meat quality traits in 400 purebred Holstein bulls was examined using polymerase chain reaction and restriction fragment length polymorphism method. In the current study, the CAPN1, CAST and GHR genotypes confirmed significant associations with important traits in adequate numbers of animals.
Sena Ardicli, Deniz Dincel, Hale Samli, and Faruk Balci
Arch. Anim. Breed., 60, 61–70, https://doi.org/10.5194/aab-60-61-2017, https://doi.org/10.5194/aab-60-61-2017, 2017
Short summary
Short summary
The present study was based on the association of polymorphisms at LEP, CAST, CAPN1, GHR, FABP4 and DGAT1 genes with fattening performance and carcass traits in Simmental bulls. Results indicated that final weight, fattening period, total weight gain and average daily gain differentiated the CAST and CAPN1 marker genotypes. Moreover, a novel effect of the LEP A80V on carcass weight and dressing percentage was observed. The results could be indicative for future studies on beef production.
Hamed Amirpour Najafabadi, Saeid Ansari Mahyari, Mohammad Ali Edriss, and Eva Strapakova
Arch. Anim. Breed., 59, 387–393, https://doi.org/10.5194/aab-59-387-2016, https://doi.org/10.5194/aab-59-387-2016, 2016
Short summary
Short summary
This study aimed to use survival analysis and examine the factors affecting functional herd life (FHL) of cows in Isfahan using the Weibull proportional risk model in Isfahan to estimate of breeding values for functional herd life. The SC, milk production, age at first calving and milk period showed significant effects on LPL (P < 0.001) according to the likelihood ratio test. Although there were some fluctuations in genetic trends, an overall increase was observed which leads to a longer FHL
Eva Strapáková, Juraj Candrák, and Peter Strapák
Arch. Anim. Breed., 59, 329–335, https://doi.org/10.5194/aab-59-329-2016, https://doi.org/10.5194/aab-59-329-2016, 2016
Short summary
Short summary
The advantages of increasing lactation persistency in dairy cattle are indisputable on the practical herd level. More persistent lactation brings a longer high-production period. In this study estimate the breeding values of lactation persistency, test day of milk yield, somatic cell score, reproductive traits (calving interval, days open), and longevity in Slovak Holstein dairy cattle were estimated and the relationship between persistency of lactation and other selected trait was analyzed.
Xiaojuan Long, Xibi Fang, Ping Jiang, Hang Xiao, Haibin Yu, Mengjiao Zhou, Yunzhi Pan, Chunyan Lu, Zhihui Zhao, and Runjun Yang
Arch. Anim. Breed., 59, 301–307, https://doi.org/10.5194/aab-59-301-2016, https://doi.org/10.5194/aab-59-301-2016, 2016
Short summary
Short summary
AGPAT6 is a key candidate gene in the lipid metabolism pathway. We detected two single nucleotide polymorphisms (SNPs) in bovine AGPAT6 exons, and we analyzed 33 traits associated with meat quality and the carcass of Chinese Simmental cattle. SNP1 was significantly associated with back fat thickness and fat coverage rate. SNP2 was significantly associated with fat coverage rate and marbling score. Thus, the SNPs of AGPAT6 may be genetic factors influencing carcass composition of beef cattle.
Hafedh Ben Zaabza, Abderrahmen Ben Gara, Hedi Hammami, Mohamed Amine Ferchichi, and Boulbaba Rekik
Arch. Anim. Breed., 59, 243–248, https://doi.org/10.5194/aab-59-243-2016, https://doi.org/10.5194/aab-59-243-2016, 2016
Short summary
Short summary
A Bayesian and REML analyses were used on Tunisian dairy cattle data. Genetic parameters for 305-day milk, fat, and protein yields were estimated. Heritability estimates by using Bayesian method ranged from 0.187 to 0.273, and slightly higher than the corresponding REML. Large genetic correlations (> 0.88) among milk, fat, and protein yields were found for the two methods. This study suggests that results from both methods were reasonably similar to suggest both methods can be used.
Hafedh Ben Zaabza, Abderrahmen Ben Gara, Hedi Hammami, Borni Jemmali, Mohamed Amine Ferchichi, and Boulbaba Rekik
Arch. Anim. Breed., 59, 209–213, https://doi.org/10.5194/aab-59-209-2016, https://doi.org/10.5194/aab-59-209-2016, 2016
Short summary
Short summary
Genetic parameters for 11 456 Tunisian Holstein cows were estimated for the following five reproductive traits: calving interval (CI), calving to first service interval, calving to conception interval (CCI), first service to conception interval and number of services per conception. Low heritabilities were estimated for these traits, and genetic correlation estimates between them were moderately high. The CCI–CI genetic correlation was 0.85, indicating that they are the same trait genetically.
K. Abfalter, W. Brade, and O. Distl
Arch. Anim. Breed., 59, 71–77, https://doi.org/10.5194/aab-59-71-2016, https://doi.org/10.5194/aab-59-71-2016, 2016
Short summary
Short summary
Estimated breeding values (EBVs), relative breeding values (RBVs), and daughter yield deviations of Holstein cows with exceptional longevity (more than nine lactations completed) and the RBVs of their sires were analyzed. Exceptional cows had on average significantly lower EBVs for yield traits but significantly higher RBVs for somatic cell score (RZS) and functional longevity (RZN). Correlations among the proportion of exceptional cows per sire and RZN, RZS as well as fitness were positive.
Cited articles
Aznarez, I., Barash, Y., Shai, O., He, D., Zielenski, J., Tsui, L. C.,
Parkinson, J., Frey, B. J., Rommens, J. M., and Blencowe, B. J.: A systematic
analysis of intronic sequences downstream of 5' splice sites reveals a
widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative
splicing regulation, Genom Res. 18, 1247–1258,
https://doi.org/10.1101/gr.073155.107, 2008.
Block, S. S., Butler, W. R., Ehrhardt, R. A., Bell, A. W., van Amburgh, M. E., and
Boisclair, Y. R.: Decreased concentration of plasma leptin in periparturient
dairy cows is caused by negative energy balance, J. Endocrinol., 171,
339–348, https://doi.org/10.1677/joe.0.1710339, 2001.
Buchanan, F. C., Fitzsimmons, C. J., van Kessel, A. G., Thue, T. D.,
Winkelman-Sim, D. C., and Schmutz, S. M.: Association of a missense mutation in
the bovine leptin gene with carcass fat content and leptin mRNA levels,
Genet. Sel. Evol., 34, 105–116, https://doi.org/10.1186/1297-9686-34-1-105,
2002.
Byun, S. O., Fang, Q., Zhou, H., and Hickford, J. G.: An effective method for
silver-staining DNA in large numbers of polyacrylamide gels, Anal. Biochem.,
385, 174–175, https://doi.org/10.1016/j.ab.2008.10.024, 2009.
Chasin, L.: Searching for splicing motifs, Adv. Exp. Med. Biol., 623, 85–106, https://doi.org/10.1007/978-0-387-77374-2_6, 2007.
Dunner, S., Miranda, M. E., Amigues, Y., Canon, J., Georges, M., Hanset, R.,
Williams, J., and Menissier, F.: Haplotype diversity of the myostatin gene among
beef cattle breeds, Genet. Sel. Evol., 35, 103–118,
https://doi.org/10.1186/1297-9686-35-1-103, 2003.
Edwards, C. J., Bollongino, R., Scheu, A., Chamberlain, A., Tresset, A.,
Vigne, J.-D., Baird, J. F. G., Larson, S. Y., Ho, S. Y. W., and Heupink, T. H.:
Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for
domestic cattle and no indication of domestication of European aurochs,
Proc. Biol. Sci., 274, 1377–1385, https://doi.org/10.1098/rspb.2007.0020, 2007.
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbaek, C.,
Flier, J. S., Saper, C. B., and Elmquist, J. K.: Leptin differentially regulates
NPY and POMC neurons projecting to the lateral hypothalamic area, Neuron, 23,
775–786, https://doi.org/10.1016/S0896-6273(01)80035-0, 1999.
Elmquist, J. K., Elias, C. F., and Saper, C. B.: From lesions to leptin:
hypothalamic control of food intake and body weight, Neuron, 22, 221–232,
https://doi.org/10.1016/s0896-6273(00)81084-3, 1999.
Epstein, H.: The origin of domestic animals of Africa, Africana Publishing
Corporation, New York, USA, available at: https://hdl.handle.net/10568/70619 (last access: 2 February 2020), 1971.
Epstein, H. and Mason, I. L.: Cattle, in: Evolution of Domesticated Animals, edited by:
Mason, I. L., Longman Group, Essex, 1984.
Gong, H., Zhou, H., and Hickford, J. G.: Diversity of the glycine/tyrosine-rich
keratin-associated protein 6 gene (KAP6) family in sheep, Mol. Biol. Rep.,
38, 31–35, https://doi.org/10.1007/s11033-010-0074-6, 2011.
Haegeman, A., van Zeveren, A., and Peelman, L. J.: New mutation in exon 2 of the
bovine leptin gene, Anim. Genet., 31, 79,
https://doi.org/10.1111/j.1365-2052.2000.579-14.x, 2000.
Hiendleder, S., Lewalski, H., and Janke, A.: Complete mitochondrial genomes of
Bos taurus and Bos indicus provide new insights into intraspecies variation, taxonomy and
domestication, Cytogenet. Genome Res., 120, 150–156,
https://doi.org/10.1159/000118756, 2008.
Hiller, M., Zhang, Z., Backkofen, R., and Stamm, S.: PremRNA secondary
structures influence exon recognition, PLoS Genet., 3, e204,
https://doi.org/10.1371/journal.pgen.0030204, 2007.
Houseknecht, K. L., Baile, C. A., Matteri, R. L., and Spurlock, M. E.: The biology
of leptin: A review, J. Anim. Sci., 76, 1405–1420,
https://doi.org/10.2527/1998.7651405x, 1998.
Kadokawa, H., Blache, D., Yamada, Y., and Martin, G. B.: Relationships between
changes in plasma concentrations of leptin before and after parturition and
the timing of first postpartum ovulation in high-producing Holstein dairy
cows, Reprod. Fert. Develop., 12, 405–411, https://doi.org/10.1071/RD01001,
2000.
Komisarek, J. and Dorynek, Z.: Polymorphisms of leptin and leptin receptor
genes in the polish population of Holstein-Friesian bulls, Ann. Anim. Sci.,
5, 253–260, 2005.
Konfortov, B. A., Licence, V. E., and Miller, J. R.: Re-sequencing of DNA from a
diverse panel of cattle reveals a high level of polymorphism in both intron
and exon, Mamm. Genome, 10, 1142–1145, https://doi.org/10.1007/s003359901180,
1999.
Lagonigro, R., Wiener, P., Pilla, F., Woolliams, J. A., Williams, J. L.: A new
mutation in the coding region of the bovine leptin gene associated with feed
intake, Anim. Genet., 34, 371–374,
https://doi.org/10.1046/j.1365-2052.2003.01028.x, 2003.
Mattioli, R. C., Pandey, V. S., Murray, M., and Fitzpatrick, J. L.: Immunogenetic
influences on tick resistance in African cattle with particular reference to
trypanotolerant N'Dama (Bos taurus) and trypanosusceptible Gobra zebu (Bos indicus) cattle, Acta
Trop., 75, 263–277, https://doi.org/10.1016/S0001-706X(00)00063-2, 2000.
NextGen Consortium: The European Union's Seventh Framework Programme
(FP7/2010-2014) provided funding for the project under grant agreement no
244356-“NextGen”, available at:
https://cordis.europa.eu/docs/results/244/244356/final1-nextgen-final-report-12092014-v2.pdf, last access: 31 January 2020.
Pomp, D., Zou, T., Clutter, A. C., and Barendse, W.: Rapid communication: mapping
of leptin to bovine chromosome 4 by linkage analysis of a PCR-based
polymorphism, J. Anim. Sci., 75, 14–27,
https://doi.org/10.2527/1997.7551427x, 1997.
Rock, F. L., Altman, S. W., van Heek, M., Kastelein, R. A., and Bazan, J. F.: The leptin
haemopoietic cytokine fold is stabilized by an intrachain disulfide bond,
Horm. Metab. Res., 28, 649–652, https://doi.org/10.1055/s-2007-979871, 1996.
Santos-Alvarez, J., Goberna, R., and Sanchez-Margalet, V.: Human leptin
stimulates proliferation and activation of human circulating monocytes,
Cell. Immunol., 194, 6–11, https://doi.org/10.1006/cimm.1999.1490, 1999.
Sjakste, T., Paramonova, N., Grislis, Z., Trapina, I., and Kairisa, D.: Analysis
of the single-nucleotide polymorphism in the 5'UTR and part of intron 1 of
the sheep MSTN gene, DNA Cell Biol., 30, 433–444,
https://doi.org/10.1089/dna.2010.1153, 2011.
Sprang, S. R. and Bazan, J. F.: Cytokine structural taxonomy and mechanisms of
receptor engagement, Curr. Opin. Struc. Biol., 5, 114–121,
https://doi.org/10.1016/0959-440X(93)90144-A, 1993.
Stone, R. T., Kappes, S. M., and Beattie, C.: Two polymorphic microsatellites within
an 18 kb genomic clone containing the bovine ob gene, Anim. Genet., 27,
64,
1996.
Yutzey, K. E., Kline, R. L., and Konieczny, S. F.: An internal regulatory element
controls troponin I gene expression, Mol. Cell Biol., 9, 1397–1405,
https://doi.org/10.1128/mcb.9.4.1397, 1989.
Zhang, F., Basinski, M. B., Beals, J. M., Briggs, S. L., Churgay, L. M., Clawson,
D. K., DiMarchi, R. D., Furman, T. C., Hale, J. E., Hsiung, H. M., Schoner, B. E.,
Smith, D. P., Zhang, X. Y., Wery, J. P., and Schevitz, R. W.: Crystal structure of the
obese protein leptin-E100, Nature, 387, 206–209, https://doi.org/10.1038/387206a0,
1997.
Zhou, H., Hickford, J. G., and Fang, Q.: A two-step procedure for extracting
genomic DNA from dried blood spots on filter paper for polymerase chain
reaction amplification, Anal. Biochem., 354, 159–161, https://doi.org/10.1016/j.ab.2006.03.042, 2006.
