Articles | Volume 62, issue 2
Original study
26 Jul 2019
Original study |  | 26 Jul 2019

Potential of TLR-gene diversity in Czech indigenous cattle for resistance breeding as revealed by hybrid sequencing

Karel Novák, Marek Bjelka, Kalifa Samake, and Terezie Valčíková

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Cited articles

Abdel-Shafy, H., Bortfeldt, R. H., Tetens, J., and Brockmann, G. A.: Single nucleotide polymorphism and haplotype effects associated with somatic cell score in German Holstein cattle, Genet. Sel. Evol., 46, 35,, 2014. 
Anthoney, N., Foldi, I., and Hidalgo, A.: Toll and Toll-like receptor signalling in development, Development, 145, UNSP dev156018,, 2018. 
Beecher, C., Daly, M., Childs, S., Berry, D. P., Magee, D. A., McCarthy, T. V., and Giblin, L.: Polymorphisms in bovine immune genes and their associations with somatic cell count and milk production in dairy cattle, BMC Genet., 11, 99,, 2010. 
Bhaladhare, A., Sharma, D., Kumar, A., Sonwane, A., Chauhan, A., Singh, R., Kumar, P., Yadav, R., Baqir, M., Bhushan, B., and Prakash, O.: Single nucleotide polymorphisms in toll-like receptor genes and case-control association studies with bovine tuberculosis, Vet. World, 9, 458–464, 2016. 
Bilgen, N., Kul, B. C., Offord, V., Werling, D., and Ertugrul, O.: Determination of genetic variations of Toll-like receptor (TLR) 2, 4, and 6 with next-generation sequencing in native cattle breeds of Anatolia and Holstein Friesian, Diversity, 8, 23,, 2016. 
Short summary
Resequencing of diversity hidden in the innate-immunity genes of the TLR series in Czech Simmental, its conserved subpopulation, and the ancestral Czech Red cattle showed sufficient potential for infection resistance breeding regardless of the prevailing breeding for production traits on the one hand and a limited potential of diversity preserved in the historical populations on the other. The importance of the characterization of genetic resources to counteract changing infections is implied.