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Volume 60, issue 2
Arch. Anim. Breed., 60, 51–59, 2017
https://doi.org/10.5194/aab-60-51-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
Arch. Anim. Breed., 60, 51–59, 2017
https://doi.org/10.5194/aab-60-51-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.

Original study 05 Apr 2017

Original study | 05 Apr 2017

Genome-wide QTL mapping results for regional DXA body composition and bone mineral density traits in pigs

Sophie Rothammer1, Maren Bernau2, Prisca V. Kremer-Rücker2,3, Ivica Medugorac1, and Armin M. Scholz2 Sophie Rothammer et al.
  • 1Chair of Animal Genetics and Husbandry, LMU Munich, 80539 Munich, Germany
  • 2Livestock Center of the Faculty of Veterinary Medicine, LMU Munich, 85764 Oberschleissheim, Germany
  • 3University of Applied Sciences Weihenstephan-Triesdorf, 91746 Weidenbach, Germany

Abstract. In a previous study, genome-wide mapping of quantitative trait loci (QTL) for five body composition traits, three bone mineral traits and live weight was performed using whole-body dual-energy X-ray absorptiometry (DXA) data. Since QTL for bone mineral traits were rare, the current study aimed to clarify whether the mapping results were influenced by the analysed body regions. Thus, the same material (551 pigs) and methods as in the whole-body QTL mapping study were used. However, for evaluation of the DXA scans, we manually defined two body regions: (i) from the last ribs to the pelvis (A) and (ii) including the pelvis and the hind limbs (P). Since live weight was not affected by the regional analysis, it was omitted from the QTL mapping design.

Our results show an overall high consistency of mapping results especially for body composition traits. Two thirds of the initial whole-body QTL are significant for both A and P. Possible causes for the still low number of bone mineral QTL and the lower consistency found for these traits are discussed. For body composition traits, the data presented here show high genome-wide Pearson correlations between mapping results that are based on DXA scans with the time-saving whole-body standard setting and mapping results for DXA data that were obtained by time-consuming manual definition of the regions of interest. However, our results also suggest that whole-body or regional DXA scans might generally be less suitable for mapping of bone mineral traits in pigs. An analysis of single reference bones could be more useful.

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In a previous mapping study including body composition and bone mineral traits obtained by DXA scans, QTL for bone mineral traits were rare. This study aimed to clarify if the mapping results were influenced by the analysed body regions. Hence, analyses were repeated using the same material (551 pigs) and methods but two manually defined body regions instead of the initial whole-body setting. Our results show an overall high consistency of mapping results especially for body composition traits.
In a previous mapping study including body composition and bone mineral traits obtained by DXA...
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