Articles | Volume 69, issue 4
https://doi.org/10.5194/aab-69-541-2026
https://doi.org/10.5194/aab-69-541-2026
Original study
 | 
02 Oct 2026
Original study |  | 02 Oct 2026

Genetic and non-genetic factors influencing milk composition and cow metabolism

Jindřich Čítek, Eva Samková, Michaela Brzáková, Oto Hanuš, Libor Večerek, Eva Jozová, Lucie Hasoňová, Eva Baldíková, Sulaiman Mohammed Iliyasu, and Michael Rost

Cited articles

Andjelić, B., Djoković, R., Cincović, M., Bogosavljević-Bošković, S., Petrović, M., Mladenović, J., and Čukić, A.: Relationships between milk and blood biochemical parameters and metabolic status in dairy cows during lactation, Metabolites, 12, 733, https://doi.org/10.3390/metabo12080733, 2022. 
Antanaitis, R., Džermeikaitė, K., Januškevičius, V., Šimonytė, I., and Baumgartner, W.: In-line registered milk fat-to-protein ratio for the assessment of metabolic status in dairy cows, Animals, 13, 3293, https://doi.org/10.3390/ani13203293, 2023. 
Ardicli, S., Senturk, N., Bozkurt, B., Babayev, H., Selvi, T., Skolnick, S., Ter, H., Aktas, B., Isık, A., Ay, O. T., Ardicli, O., and Cobanoglu, O.: The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows, Anim. Biotechnol., 35, 2396421, https://doi.org/10.1080/10495398.2024.2396421, 2024. 
Banos, G., Woolliams, J. A., Woodward, B. W., Forbes, A. B., and Coffey, M. P.: Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows, J. Dairy Sci., 91, 3190-3200, https://doi.org/10.3168/jds.2007-0930, 2008. 
Benedet, A., Manuelian, C. L., Zidi, A., Penasa, M., and De Marchi, M.: Invited review: β-hydroxybutyrate concentration in blood and milk and its associations with cow performance, animal, 13, 1676–1689, https://doi.org/10.1017/S175173111900034X, 2019. 
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Short summary
The aim of this study was to evaluate the influence of genetic and non-genetic factors on the composition of milk and cow metabolism. Farms and lactation stage had a strong effect. Polymorphisms of lipogenic genes had a low effect on milk parameters and the fatty acid profile. The association between β-hydroxybutyric acid and the fat-to-protein ratio was significant. The level of β-hydroxybutyric acid in milk may serve as a field predictor of ketosis in animals.
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