Articles | Volume 69, issue 3
https://doi.org/10.5194/aab-69-517-2026
https://doi.org/10.5194/aab-69-517-2026
Original study
 | 
17 Sep 2026
Original study |  | 17 Sep 2026

Metabolic, adipokine (irisin, spexin, visfatin), and ER stress (GRP78) responses in multiparous Brown Swiss cows: a multivariate approach across physiological stages and body condition scores

Gökşad Cemil Kotan, Şeyma Aydemir, and Bülent Bayraktar

Cited articles

Adewuyi, A. A., Gruys, E., and van Eerdenburg, F. J.: Non-esterified fatty acids (NEFA) in dairy cattle: a review, Vet. Q., 27, 117–126, 2005. 
AOAC International: Official methods of analysis of AOAC International, 20th edn., AOAC International, Gaithersburg, MD, ISBN 978-0-935584-87-5, 2016. 
Bayraktar, B.: Endokrin Sistem, in: Sağlık Bilimleri İçin Fizyoloji, edited by: Taşkın, E. and Kocahan, S., Akademisyen Kitabevi, Ankara, Türkiye, 239–270, ISBN: 978-625-7795-60-9, 2020. 
Bayraktar, B. and Genç, M.: The effect of change in body condition score at different stages of pregnancy on serum apelin-36 hormone levels in Simmental cattle, J. Anim. Vet. Adv., 20, 81–85, 2021. 
Bayraktar, B., Tekce, E., Aksakal, V., Takma, Ç., Bayraktar, F. G., and Şengül, B.: Effects of race, gender, body condition score and pregnancy on serum Apelin levels in ewe, J. Agr. Sci., 26, 363–372, https://doi.org/10.15832/ankutbd.526907, 2020. 
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Short summary

This study investigates metabolic adaptation, novel hormones, and cellular stress in dairy cows across pregnancy and lactation stages with different body condition scores. Results show that the dry period and early lactation represent critical metabolic stress points with elevated cellular stress and fat mobilization. Monitoring these novel biomarkers provides practical insights for optimizing transition-period nutritional strategies and herd health management.

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