Archives Animal Breeding
Archives Animal Breeding
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Articles | Volume 68, issue 3
Articles | Volume 68, issue 3
https://doi.org/10.5194/aab-68-555-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-68-555-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 68, issue 3
Original study
 | 
11 Sep 2025
Original study |  | 11 Sep 2025

Non-steroidal anti-inflammatory drugs improve bovine blastocyst formation and quality in in vitro culture

Kübra Karakaş Alkan, Fatma Satılmış, Yunus Emre Deniz, Mustafa Bodu, Muhammed Furkan Çiftçi, Ömer Faruk Yeşilkaya, and Hasan Alkan

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Cited articles

Aguila, L., Osycka-Salut, C., Treulen, F., and Felmer, R.: Pluripotent Core in Bovine Embryos: A Review, Animals, 12, 1010, https://doi.org/10.3390/ani12081010, 2022. 
Alkan, H., Satilmis, F., Demirel, M. A., Bodu, M., Yesilkaya, O. F., Ciftci, M. F., Erdem, H., Tekindal, M. A., and Alkan, K. K.: Does Using Microfluidic Sperm Sorting Chips in Bovine IVEP Affect Blastocyst Development?, Reprod. Domest. Anim., 58, 1012–1020, https://doi.org/10.1111/rda.14398, 2023. 
Antunes, G., Chaveiro, A., Santos, P., Marques, A., Jin, H. S., and da Silva, F. M.: Influence of Apoptosis in Bovine Embryo's Development, Reprod. Domest. Anim., 45, 26–32, https://doi.org/10.1111/j.1439-0531.2008.01131.x, 2010. 
Bicici, E., Satilmis, F., Bodu, M., Demirel, M. A., Karakas Alkan, K., and Alkan, H.: Effect of putrescine supplementation to in vitro maturation medium on embryo development and quality in cattle, Anim. Biotechnol., 34, 3887–3896, https://doi.org/10.1080/10495398.2023.2236660, 2023. 
Bó, G. A. and Mapletoft, R. J.: Evaluation and Classification of Bovine Embryos, Anim. Reprod., 10, 344–348, 2013. 
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Prostaglandins have a detrimental effect on embryo development during the early phase of in vitro culture. In this study, non-steroidal anti-inflammatory drugs (NSAIDs) were supplemented in the in vitro culture medium to eliminate the negative effect of prostaglandins during in vitro embryo culture, and the effect of these NSAIDs on embryo development and quality was evaluated. Embryos were assessed on day 7 based on developmental stage, quality, apoptotic index, and developmental competence.
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