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Articles | Volume 68, issue 2
Articles | Volume 68, issue 2
https://doi.org/10.5194/aab-68-287-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-68-287-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 68, issue 2
Original study
 | 
15 May 2025
Original study |  | 15 May 2025

miR-383 regulates sheep granular cell proliferation and apoptosis by targeting Bcl-2

Binglei Zhang, Saiyi Sun, Wanhang Jia, Jiaxin Yang, Xueru Dou, Yang Wang, and Yuqin Wang

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Short summary
Follicular atresia is a process that eliminates follicles and oocytes. MicroRNAs, including miR-383, play a vital role in regulating follicular atresia by affecting granular cell (GC) apoptosis and proliferation. In this study, RT-qPCR, western blot, luciferase reporter assay, and flow cytometry are used to detect the regulation of miR-383 in sheep GCs. The results show that miR-383 inhibits the proliferation and promotes GC apoptosis, and the mechanism of miR-383 affecting apoptosis is to target Bcl-2.
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