ICAR-Directorate of Poultry Research, Rajendranagar, Hyderabad, India
Arun Kumar Burramsetty
Current Address: MEXT Doctoral Scholar, Graduate School of
Comprehensive Human Sciences, Department of Biomedical Sciences, University
of Tsukuba, Tsukuba, Japan
Kannaki Ramasamy
ICAR-Directorate of Poultry Research, Rajendranagar, Hyderabad, India
Rudra Nath Chatterjee
ICAR-Directorate of Poultry Research, Rajendranagar, Hyderabad, India
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Substitution of amino acids due to single nucleotide polymorphisms (SNPs) in pattern recognition receptors leads to altered innate immunity to diseases. The present study shows extensive polymorphisms in coding sequences of TLR (TLR3, TLR1LA) and NLR (NOD1) genes compared to the RLR (MDA5, LGP2) gene. SNPs were higher in Indian chicken breeds (Ghagus and Nicobari) compared to the WLH breed. A computer simulation study revealed a neutral effect of most non-synonymous SNPs on protein function.
Substitution of amino acids due to single nucleotide polymorphisms (SNPs) in pattern recognition...
