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Articles | Volume 61, issue 4
Articles | Volume 61, issue 4
https://doi.org/10.5194/aab-61-441-2018
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/aab-61-441-2018
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 61, issue 4
Original study
 | 
12 Nov 2018
Original study |  | 12 Nov 2018

Polymorphisms in pattern recognition receptor genes of indigenous and White Leghorn breeds of chicken

Santosh Haunshi, Arun Kumar Burramsetty, Kannaki Ramasamy, and Rudra Nath Chatterjee

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Latest update: 14 Dec 2024
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Short summary
Substitution of amino acids due to single nucleotide polymorphisms (SNPs) in pattern recognition receptors leads to altered innate immunity to diseases. The present study shows extensive polymorphisms in coding sequences of TLR (TLR3, TLR1LA) and NLR (NOD1) genes compared to the RLR (MDA5, LGP2) gene. SNPs were higher in Indian chicken breeds (Ghagus and Nicobari) compared to the WLH breed. A computer simulation study revealed a neutral effect of most non-synonymous SNPs on protein function.
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