Articles | Volume 59, issue 1
https://doi.org/10.5194/aab-59-113-2016
https://doi.org/10.5194/aab-59-113-2016
Original study
 | 
29 Feb 2016
Original study |  | 29 Feb 2016

Effects of peripheral administration of ghrelin antagonist [D-Lys3]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Habib Aghdam Shahryar and Alireza Lotfi

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Subject: Physiology | Animal: Birds
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Cited articles

Aghdam Shahryar, H. and Lotfi, A.: Effect of in ovo ghrelin administration on thyroid hormones and some of serum biochemical parameters in newly-hatched chicks, Kafkas Univ. Vet. Fak. Derg., 19, 857–860, 2013.
Aghdam Shahryar, H. and Lotfi, A.: Effects of peptidic growth hormone secretagogue receptor (GHS-R) antagonist [D-Lys3] on some of serum hormonal and biochemical parameters in Wistar rat model, Arq. Bras. Endocrinol. Metabol., 58, 288–291, 2014.
Asakawa, A., Inui, A., Kaga, T., Katsuura, G., Fujimiya, M., Fujino, M. A., and Kasuga, M.: Antagonism of ghrelin receptor reduces food intake and body weight gain in mice, Gut, 52, 947–952, 2003.
Buyse, J., Janssen, S., Geelissen, S., Swennen, Q., Kaiya, H., Darras, V. M., and Dridi, S.: Ghrelin modulates fatty acid synthase and related transcription factor mRNA levels in a tissue-specific manner in neonatal broiler chicks, Peptides, 30, 1342–1347, 2009.
Costantini, V. J., Vicentinim, E., Sabbatini, F. M., Valerio, E., Lepore, S., Tessari, M., Sartori, M., Michielin, F., Melotto, S., Bifone, A., Pich, E. M., and Corsi, M.: GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs, Neuroendocrinology, 94, 158–168, 2011.
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Short summary
In present study, effects of peripheral administration of ghrelin antagonist [D-Lys3] GHRP-6 on chicken performance, thyroid hormone level and serum biochemical parameters were investigated. The results indicate that ghrelin antagonist [D-Lys3] GHRP-6 reduces feed intake and body weight. With regard to increase in T4 level, it can be inferred that [D-Lys3] GHRP-6 may increase metabolic rate, lipolysis and weight loss, which is similar to results obtained in mammalian species.